The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
194 snips
Feb 21, 2025 • 1h 24min
The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253
Dr. Andrew Salzman, a Harvard-trained physician and scientist renowned for creating the first PARP1 inhibitor, reveals the transformative power of NAD in enhancing energy and longevity. He discusses how NAD levels drop with age, leading to fatigue and disease risks. Discover the hidden enzyme CD38 that hampers your health, and learn actionable strategies to boost NAD naturally for better mitochondrial function. Salzman also challenges the conventional supplement industry, advocating for innovative approaches to aging and cellular health.
129 snips
Feb 20, 2025 • 1h 20min
Fix Your Blood Sugar: The FASTEST Way to Burn Fat, Optimize Hormones & Reverse Disease | Benjamin Bikman : 1252
Dr. Benjamin Bikman, a Ph.D. professor at BYU and author of "How Not To Get Sick," joins the discussion to reveal groundbreaking insights into insulin resistance and its role in obesity and chronic disease. He debunks popular dietary myths, explaining how hormones, rather than just calories, impact metabolism. Discover how dietary fat may reverse metabolic dysfunction and the importance of fasting and light quality for health. Plus, learn why some people maintain a healthy weight despite high carb intake and the hidden connections between insulin and skin health.
143 snips
Feb 18, 2025 • 55min
Rick Rubin: How to Hack Your Mind for Creative Breakthroughs : 1251
Rick Rubin, a legendary music producer known for working with icons like Jay-Z and Johnny Cash, shares his insights into unlocking creativity. He discusses the importance of meditation and mindfulness for artistic breakthroughs. Rubin unveils how biohacking can elevate creative performance and explains the surprising connection between experimentation and artistic flow. He emphasizes creating an environment that nurtures creativity and reveals his personal tools for mental clarity, enabling artists to tap into their full potential.
146 snips
Feb 13, 2025 • 57min
Tony Robbins on the Ultimate Secrets to Wealth, Mindset, and Success : 1250
Tony Robbins, a bestselling author and entrepreneur, shares insights from his decades of coaching billionaires and elite performers. He discusses how a scarcity mindset holds people back and reveals strategies to achieve financial freedom. Fear, he says, is the greatest enemy in personal success. Robbins emphasizes investing in both health and wealth, introducing innovative wellness techniques and groundbreaking advancements in stem cell therapy. He explores the true essence of happiness and fulfillment beyond financial gain, urging listeners to pursue passion and purpose.
25 snips
Feb 11, 2025 • 40min
Timbaland's Blueprint: How to Lose 130 Pounds, Beat Addiction, and Change Your Life TODAY! : 1249
Timbaland, the legendary producer behind hits for Jay-Z and Beyoncé, shares his remarkable journey of overcoming addiction and losing 130 pounds. He reveals the powerful mindset shift that enabled his transformation and stresses that self-discipline trumps willpower. Timbaland opens up about the realities of opioid addiction, his clean recovery without rehab, and the importance of daily habits. He also emphasizes the role of vulnerability in healing, urging listeners to embrace their personal stories for growth.
240 snips
Feb 6, 2025 • 1h 2min
Gary Brecka: The SECRET Blood Marker That Could Save Your Life! (pt. 2) : 1248
In this engaging discussion, Gary Brecka, a human biologist and longevity expert, uncovers the critical role of methylation in health. He reveals how genetic factors like the MTHFR mutation can impact mental health issues such as anxiety and ADHD, stemming from nutrient deficiencies rather than just brain chemistry. Gary highlights the gut-brain connection, explains why many diets fail, and emphasizes the importance of the homocysteine marker for longevity. Discover simple lifestyle changes that can boost energy and reverse serious health challenges.
75 snips
Feb 5, 2025 • 37min
Gary Brecka: The World Is KILLING You—Use AI To Restore Testosterone, Energy & Longevity (Pt. 1) : 1247
Gary Brecka, a leading expert in human longevity and hormone optimization, uncovers the hidden crises affecting our health. He discusses the alarming drop in testosterone levels and how corporate greed and environmental toxins play a role. Brecka emphasizes the need for functional medicine and biohacking for optimal health. The impact of AI on personalized hormone therapy and longevity strategies is explored. Additionally, he reveals myths around cholesterol and heart disease, challenging mainstream medical narratives.
149 snips
Jan 30, 2025 • 1h 40min
Ancient Secrets THEY Hid from You (That Still Work Today!) – Lost Technology, The Pyramid Code, and Quantum Reality | Billy Carson (Harvard & MIT) & Elisabeth Carson : 1246
Billy Carson, a Harvard-certified expert in ancient civilizations, and Elisabeth Carson, a bestselling author and neuroscience researcher, dive into the mysteries of lost technologies and quantum reality. They explore the Great Pyramid as a potential energy generator and discuss ancient civilizations’ understanding of frequency and longevity. Their insights bridge ancient wisdom with modern biohacking, revealing how suppressed knowledge can redefine wellness. The couple shares emotional journeys, emphasizing resilience and the transformative power of trauma in personal growth.
122 snips
Jan 28, 2025 • 1h 28min
Stop Counting Calories! Diet Myths Exposed (And What to Do Instead) | Dr. Nick Norwitz : 1245
In this enlightening discussion, Dr. Nick Norwitz, a metabolic health expert with a PhD from Oxford and an MD from Harvard, debunks the myth of calorie counting in weight loss. He reveals that metabolism is far more complex than the traditional 'eat less, move more' approach. Dr. Norwitz discusses the healing powers of ketosis and fasting, the importance of gut health, and even the surprising links between viruses and food addiction. This episode is a treasure trove of insights on personalized nutrition for optimal health!
76 snips
Jan 23, 2025 • 1h 35min
How to Hack Your Stress and Engineer Your Tears to BOOST Longevity | Jeff Krasno : 1244
Jeff Krasno, founder of Commune and author of "Good Stress," discusses the surprising benefits of mastering stress rather than avoiding it. He reveals how crying is a powerful emotional biohack that regulates stress and encourages resilience. Krasno explains the difference between good and bad stress, emphasizing that discomfort can lead to growth. He also explores the science behind emotional regulation and the importance of community connections for health, urging listeners to embrace moments of struggle to enhance their longevity.
