The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
200 snips
Mar 25, 2025 • 1h 11min
This Is Your Brain on 2025: The Biohacker’s Guide to Mental Clarity & Mood | Dr. Drew Ramsey : 1263
Dr. Drew Ramsey, a Columbia University psychiatrist and pioneer in nutritional neuroscience, joins the conversation to uncover how modern life affects mental health. He discusses the links between brain inflammation, anxiety, and unhealthy lifestyles. Discover how movement, like dancing, can boost brain function and the crucial role of nutrition in emotional well-being. Explore the hidden impacts of technology on relationships and the need for personalized mental fitness approaches. Plus, the kale debate reveals there's no one-size-fits-all solution!
107 snips
Mar 20, 2025 • 1h 28min
The Science of Consciousness: What’s Beyond the Brain? | Mark Gober : 1262
Mark Gober, a thought-provoking author and consciousness researcher, delves into the idea that our consciousness may extend beyond the confines of the brain. He discusses near-death experiences and psychic phenomena, revealing insights from declassified CIA documents. Gober challenges traditional views on free will and explores how practices like meditation and sensory deprivation can enhance awareness. He also touches on the debate about AI consciousness, urging listeners to rethink their understanding of reality and the nature of existence.
59 snips
Mar 18, 2025 • 1h 15min
The Hidden Cost of Being Too Nice: Why People-Pleasing is Silently Killing Your Success | Scott Barry Kaufman : 1261
Scott Barry Kaufman, a renowned psychologist and author of 'Rise Above,' discusses the hidden costs of people-pleasing and the psychology of empowerment. He explains how toxic altruism and external validation can hinder personal growth. The conversation covers the crucial shift from a victim to an empowerment mindset, and how emotional resilience can combat societal pressures. Kaufman shares insights on self-actualization and the neuroscience behind confidence, highlighting the importance of boundaries for reclaiming one's power.
97 snips
Mar 14, 2025 • 58min
MDMA Therapy Without the Drugs? How Vibration Hacks Your Brain for Neuroplasticity | Dave Rabin : 1260
Dave Rabin, a neuroscientist and psychiatrist renowned for his work on the Apollo Neuro device, joins to explore the intersection of vibrations and mental health. They discuss how vibrations can replicate the benefits of MDMA therapy in enhancing neuroplasticity and emotional healing without drugs. Rabin elaborates on the Apollo device's ability to regulate stress, improve focus, and aid recovery by harnessing the body's natural responses to sound. The conversation also delves into innovative approaches for treating ADHD and the importance of emotional connections in well-being.
117 snips
Mar 13, 2025 • 1h 10min
Brain Hacking 101: The Science of Self-Sabotage & Mind Reprogramming | Bizzie Gold : 1259
In this engaging discussion, Bizzie Gold, a mind architect and creator of The Break Method, reveals how subconscious scripts can sabotage your success. She dives into the science of self-deception and the early experiences that hardwired our thoughts. Bizzie also shares powerful techniques to challenge negative thinking, explore emotional cycles, and even incorporates AI to enhance self-improvement. Discover how navigating emotions and reprogramming your brain can lead to true transformation and a more empowered life.
71 snips
Mar 11, 2025 • 1h 12min
How Learning a New Language Rewires Your Brain—Lessons from the Pirahã Tribe | Daniel Everett : 1258
Daniel Everett, a renowned linguist and explorer, discusses his groundbreaking research with the Pirahã tribe, revealing how their unique language reshapes cognitive processes. He challenges traditional theories by emphasizing that language not only facilitates communication but also influences thought and perception. The conversation dives into the neurological benefits of learning new languages, the potential for AI to truly 'think,' and how our environments and even altered states of consciousness impact language evolution.
91 snips
Mar 6, 2025 • 1h 19min
Your Genes AREN’T Your Fate—The NEW Science of DNA Biohacking for SuperHuman Health | Sharon Hausman-Cohen : 1257
Sharon Hausman-Cohen, a Harvard-trained physician and genomics expert, reveals how our DNA isn't our destiny. She discusses the empowering science of genetic optimization, explaining how to activate longevity genes and inhibit disease pathways. The conversation covers the truth about 'bad' genes, such as MTHFR and APOE4, along with personalized strategies to combat brain fog and fatigue. Sharon highlights breakthroughs in DNA biohacking and the future of gene editing for enhanced health, making clear that personalized medicine is the key to unlocking our full potential.
76 snips
Mar 5, 2025 • 28min
How to Build New Habits and KEEP Them! BJ Fogg & James Clear : 1256
BJ Fogg, a Stanford researcher and author of 'Tiny Habits,' teams up with James Clear, the mastermind behind 'Atomic Habits,' to unravel the secrets of habit formation. They reveal that emotions—not just willpower—play a pivotal role in making habits stick. BJ shares techniques for leveraging joy to drive behavior change, while James emphasizes the power of small, cumulative decisions. Together, they explore the importance of clear cues, celebrating progress, and a compassionate approach to shaping lasting habits.
114 snips
Feb 27, 2025 • 55min
Hacking Oxytocin, How to Use Rapamycin, Level Up Your At-Home Cold Plunge, Curing Asperger’s & More! AMA #1 with Dave Asprey : 1255
Discover how to naturally enhance oxytocin for better relationships and reduced stress. Learn tips to optimize your cold plunge routine for significant benefits in less time. Delve into the longevity potential of rapamycin and its effects on brain power and mood. Explore innovative approaches for improving emotional recognition and well-being in individuals with Asperger's. Gain insights into retraining the nervous system and the significance of emotional mastery techniques for personal healing and growth.
260 snips
Feb 25, 2025 • 1h 7min
The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes : 1254
Chris Rhodes, a biochemist and longevity researcher, discusses groundbreaking fasting mimetics that could transform health without the need to fast. He explains how Mimeo, a blend of four fasting metabolites, can extend lifespan by 96% while maintaining food intake. The conversation covers optimal fasting windows, the dangers of over-fasting on metabolism and hormones, and why traditional longevity drugs may not be effective. Rhodes highlights the balance between indulgence and health, paving the way for innovative approaches to nutrition.
