The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
120 snips
Apr 24, 2025 • 1h 19min
The Real Reason You Still Feel Tired—Even When Your Bloodwork Looks Perfect | Dr Pompa : 1273
Dr. Daniel Pompa, a leader in cellular detox and root-cause healing, discusses the hidden health issues causing chronic fatigue despite normal bloodwork. He reveals how cellular dysfunction, neurotoxicity, and hormone resistance sabotage energy and well-being. The conversation explores the dangers of toxins like glyphosate, the importance of detoxing at a cellular level, and the role of dietary fats in inflammation. Dr. Pompa emphasizes a holistic approach to health, advocating for truly understanding and addressing the root causes over merely treating symptoms.
71 snips
Apr 22, 2025 • 1h 20min
The $500 Billion Secret: Why Top Leaders Chase Stress | Sébastien Page : 1272
Sébastien Page, CIO of a major investment firm and author of 'The Psychology of Leadership', discusses how top leaders leverage stress instead of shying away from it. He uncovers why zero stress can lead to burnout and explores the pivotal role of strategic patience in decision-making. Sébastien shares fascinating insights about how losses can fuel mastery, the balance between intuition and analysis, and the importance of kindness over mere niceness in leadership. This conversation is a masterclass in transforming pressure into productivity.
59 snips
Apr 17, 2025 • 1h 30min
Web3 & the Future of Genetics: AI, Blockchain & Data Ownership with Nillion : 1271
Michael Tiffany, Co-founder and CEO of Fulcra Dynamics, dives deep into the future of personal data ownership alongside fellow innovator Vishakh. They discuss how technologies like Nillion allow secure use of genetic data without compromising privacy. Tiffany reveals the shocking truth about government access to DNA and the revolutionary potential of decentralized networks. The duo explores the concept of a 'cybernetic operating system' and its implications for health freedom, encouraging listeners to reclaim their data in the era of biohacking.
160 snips
Apr 15, 2025 • 54min
Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270
Join Dr. Steven Gundry, a leading heart surgeon and author of The Plant Paradox, as he explores the powerful connection between our gut microbiome and mental health. Discover how gut bacteria can influence your thoughts and cravings, potentially hijacking your brain. Dr. Gundry reveals shocking insights about the effects of antibiotics, glyphosate, and processed foods on gut health. He discusses how specific microbes can lead to addiction and obesity, and offers strategies for rebuilding your gut ecosystem through better dietary choices.
78 snips
Apr 11, 2025 • 60min
Longevity Scientists Discover a Breakthrough Peptide That Reverses Hair Loss | Carolina Reis Oliveira : 1269
Carolina Reis Oliveira, a longevity researcher and stem cell biologist with a PhD in immunology, joins the conversation to challenge the long-held belief that hair loss is purely genetic. She explains how senescent, or 'zombie' cells, contribute to hair thinning and reveals groundbreaking research on the OS-01 peptide, which can increase hair density by 40% in just six months. The discussion covers the impact of stress, hormones, and the scalp microbiome on hair health, promising innovative solutions for reversing hair loss and regrowing hair.
87 snips
Apr 10, 2025 • 1h 6min
Identity Hacker: How to Completely Change Your Personality at ANY Age | Olga Khazan : 1268
Olga Khazan, an award-winning journalist from The Atlantic and author of 'Me, But Better,' shares her insights on transforming personality traits. She discusses how to recode your identity, emphasizing that traits like anxiety and neuroticism are not fixed. The conversation covers the surprising connection between gut health and emotional states, the neurobiology of gratitude, and effective strategies for overcoming inner critics. Olga’s personal journey serves as a guide for anyone desiring meaningful change and resilience at any age.
66 snips
Apr 8, 2025 • 29min
Psychedelic States On-Demand (No Substances Needed) | Dr. Patrick Porter : 1267
Dr. Patrick Porter, founder of BrainTap, is an innovative mind behind a platform that enhances brain function through light, sound, and guided visualization. He discusses how to revitalize underpowered brains and access psychedelic-like states safely. Discover the power of gamma brainwaves and how they can boost cognitive performance by 19% in just six weeks. Porter shares transformative stories and insights on breaking energy depletion cycles, improving sleep, and the role of mindset in health, offering practical tools for mental enhancement without substances.
50 snips
Apr 3, 2025 • 51min
Why Gen Z Can’t Handle the Real World (and How We Can Help Them) | Jennifer Cohen : 1266
Jennifer Cohen, a bestselling author, TED speaker, and resilience expert, shares insightful perspectives on parenting for today's youth. She discusses how overprotection and technology are hindering Gen Z's ability to handle real-world challenges. Jennifer emphasizes the importance of allowing children to experience failure, explaining how participation trophies and constant praise can undermine resilience. She offers practical strategies to raise adaptable kids and highlights the benefits of embracing discomfort for personal growth.
59 snips
Apr 1, 2025 • 1h 13min
The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265
Hannah Kleinfeld, a microbiome innovation leader, dives into the often-ignored complexities of gut health. She reveals why most probiotics fail to reach your intestines and how dysbiosis can affect your brain and mood. Kleinfeld discusses the impact of GLP-1 drugs on gut bacteria and offers the 'AB 10' protocol to restore gut health after antibiotic use. With insights on the gut-brain-heart connection, she emphasizes that your gut may be influencing many of your health decisions.
76 snips
Mar 27, 2025 • 1h 18min
Scientists Just Discovered the Essential Nutrient That DOUBLES Dolphin Lifespan—But Should YOU Take It? | Stephanie Venn-Watson : 1256
Veterinary epidemiologist and longevity researcher Stephanie Venn-Watson uncovers the recent discovery of essential fatty acid C15, crucial for health and aging. She explains how this nutrient, found in long-lived U.S. Navy dolphins, is absent from modern diets and may contribute to accelerated aging. Venn-Watson discusses C15's benefits for cellular stability, mental health, and its potential to outperform major longevity drugs. Discover the surprising foods containing this essential fat and why it matters for everyone, especially pregnant women.
