The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
75 snips
May 20, 2025 • 1h 4min
The Biohacker’s Guide to CIA Mind Control & Brainwashing : 1283
Rebecca Lemov, a Harvard historian and expert on psychological manipulation, delves into the insidious nature of mind control. She reveals how techniques from MK Ultra evolved into modern forms of influence through social media and technology. The conversation explores the ethics of autonomy in an age of pervasive psychological tactics. Lemov also discusses the historical ties to psychedelics and the unsettling legacy of government experimentation. Listeners gain insights on protecting their thoughts and emotional well-being from external manipulations.
113 snips
May 16, 2025 • 1h 27min
Military Tech Goes Public: Think 30% Faster with This Brain Hack | Geoffrey Woo : 1282
In this engaging discussion, Geoffrey Woo, a Stanford-trained computer scientist and the founder of Ketone-IQ, dives into the world of brain optimization. He highlights how ketones, used by elite forces, enhance focus and improve reaction times by up to 30%. The conversation delves into the benefits of ketones over glucose for cognitive health and their potential in biohacking for athletes and entrepreneurs. Woo also shares insights on innovation in ketone production and challenges faced while securing military contracts, emphasizing resilience in the entrepreneurial journey.
31 snips
May 15, 2025 • 49min
The Anti-Aging Chamber That Rewinds Your Biological Clock|Dr. Jason Sonners : 1281
Dr. Jason Sonners, a leading expert in hyperbaric oxygen therapy, shares insights on how controlled oxygen can rejuvenate your cells and combat aging. He reveals his latest research on the contrasting effects of mild and high-pressure chambers on inflammation and cognitive performance. Listeners will learn about the revolutionary ways HBOT triggers stem cell activation and rewires genetic expression. Sonners also discusses how to enhance results by combining HBOT with fasting and red light therapies, all while navigating common misconceptions about oxygen toxicity.
79 snips
May 13, 2025 • 1h 11min
The New Science Behind Psychedelics, Exotic Shrooms, & Daily Flow-States | Matt Zemon : 1280
In this conversation, Matt Zemon, an expert on psychedelics and brain optimization, dives into how psychedelic mushrooms can unlock flow states and enhance mental clarity. He discusses the science behind psilocybin, its impact on neuroplasticity, and effective strategies for microdosing versus full doses. Zemon emphasizes the importance of using psychedelics safely and intentionally for emotional healing and personal growth. He also highlights the need for individual agency and integrates insights from both modern medicine and traditional wisdom.
147 snips
May 9, 2025 • 1h 5min
Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah : 1279
Shalin Shah, CEO of Marius Pharmaceuticals, shares insights on testosterone's crucial role in both men and women. He discusses the alarming decline of testosterone levels and why diet alone can't fix this issue. The conversation highlights the groundbreaking oral testosterone method, Kyzatrex®, which offers a safer and simpler alternative to traditional treatments. Listeners will learn about the hormone's impact on energy, mood, and longevity, along with practical advice on maintaining youthful testosterone levels for a healthier life.
109 snips
May 8, 2025 • 1h 13min
The Deadliest Room in Your House — And How to Detox It for Better Health | Aly Cohen MD : 1278
Dr. Aly Cohen, a board-certified rheumatologist and author, sheds light on the hidden dangers lurking in our homes. She reveals how common household items, from cleaning products to personal care, can disrupt hormones and contribute to autoimmune diseases. Dr. Cohen discusses microplastics and 'forever chemicals' in our environment, providing practical detox strategies to protect health and fertility. Tune in to learn how to make informed choices and create a cleaner living space for better well-being!
136 snips
May 6, 2025 • 1h 4min
Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277
Dr. Anurag Singh, Chief Medical Officer of Timeline, discusses revolutionary science in cardiovascular health. He highlights the role of mitochondria in heart failure, especially after menopause. The conversation delves into the benefits of Urolithin A, a potent molecule that rejuvenates mitochondrial function and may reverse markers of cardiac aging. Dr. Singh also shares lifestyle biohacks that can enhance heart resilience and improve overall healthspan, all while promoting endurance and cellular nutrition.
100 snips
May 1, 2025 • 41min
How Laser Therapy Boosts Mood, Mental Clarity, and Consciousness with Dr. Brandon Crawford : 1276
Dr. Brandon Crawford, a neurotherapist and founder of 528 Innovations, discusses how laser therapy can revolutionize mental health and consciousness. He explains how targeted light can rewire brainwaves, aid recovery from conditions like autism and ALS, and even activate the vagus nerve. Listeners will be fascinated by the idea that specific laser frequencies can improve mood and gut-brain communication. Crawford shares his insights on the intersection of emotion, biology, and quantum science, portraying a new approach to mental wellness through innovative light-based therapies.
142 snips
Apr 29, 2025 • 1h 43min
Conscious Bacteria? The Secret New Science of Cellular Intelligence | Zach Bush : 1275
Zach Bush, MD, a trailblazer in cellular intelligence, reveals how mitochondria can act as conscious messengers rather than mere energy producers. He discusses the symbiotic relationship between our microbiome and health, illustrating how disrupted cellular communication is linked to chronic diseases. The conversation also explores how emotional trauma affects genetic expression and mitochondrial function. Bush emphasizes the importance of restoring connections within ecosystems and the human body for optimal well-being, advocating for a holistic approach to health that embraces ancient wisdom.
232 snips
Apr 25, 2025 • 1h 6min
The End of Cardio? Burn Fat & Boost VO₂ Max in Just 8 Minutes a Week – with REHIT | Ulrich Dempfle : 1275
Ulrich Dempfle, a German-trained engineer and co-founder of CAROL Bike, introduces a revolutionary workout method called REHIT. This new approach dismantles outdated cardio advice, promoting short, 8-minute sessions that significantly improve VO₂ max and reduce diabetes risk. Dempfle discusses how REHIT outperforms traditional jogging, offers enormous fitness gains, and even benefits perimenopausal women. He also shares insights on personalizing workouts with AI, emphasizing the importance of fun and adherence for lasting fitness results.
