LONGEVITY with Nathalie Niddam #342: Unlocking The Secret Code To Fasting: The Biohack for Hunger, Longevity & Energy (How Scientists Are Hacking Your CELLS) | Chris Rhodes
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Jun 10, 2025 
In this engaging discussion, Chris Rhodes, a nutritional biochemist and CEO of Mimio Health, reveals fascinating insights into the science of fasting mimetics. He explains how fasting can stimulate beneficial cellular processes, even without extended fasting periods. Chris highlights the four key fasting mimetic molecules and their potential in promoting longevity, enhancing energy, and managing hunger. The conversation also covers the safety of these supplements and their practical applications for various age groups, offering a new perspective on health and wellness.
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Timing Matters in Fasting Benefits
- Short fasts like 16-8 provide limited benefits since the body mostly uses glycogen stores.
- Significant metabolic switching to fat burning and autophagy starts after 20 to 24 hours of fasting.
Fasting Activates Longevity Pathways
- Fasting triggers an evolutionary survival mode focusing on cell maintenance, repair, and protection instead of growth.
- Key pathways like NAD-SIRT, AMPK, and autophagy reduce energy usage and enhance longevity bio programs.
Balancing AMPK and mTOR Signals
- AMPK signals energy scarcity promoting fat metabolism and cell protection, while mTOR promotes growth and cell proliferation.
- Balancing AMPK and mTOR activation provides natural cellular homeostasis and longevity benefits.