Huberman Lab

Dr. David Sinclair: The Biology of Slowing & Reversing Aging

958 snips
Dec 27, 2021
In this engaging discussion, Dr. David Sinclair, a tenured Professor of Genetics at Harvard and a leading expert in longevity, reveals groundbreaking insights into aging. He explores how fasting, specific supplements like NMN and metformin, and lifestyle choices can potentially reverse aging. Sinclair emphasizes the importance of monitoring key blood markers to distinguish biological from chronological age. He also discusses the hidden dangers of excess iron and how novel research may provide future breakthroughs in longevity and health optimization.
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INSIGHT

Aging as a Disease

  • Aging is a disease because it's a deterioration of health, leads to sickness, and can cause death.
  • Instead of treating age-related diseases individually, focus on reversing aging itself.
INSIGHT

Epigenome and Aging

  • The epigenome, the control system of our genes, determines which genes are active.
  • Aging is a loss of information in the epigenome, like scratches on a DVD, disrupting cell function.
ADVICE

Intermittent Fasting

  • Skip one meal daily, ideally breakfast or dinner, to extend the fasting period.
  • Periods without food activate longevity genes (sirtuins) by lowering insulin levels.
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