TMHS 884: How Your Microbiome Controls Your Mental Health & The Gut-Brain Paradox - With Dr. Steven Gundry

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Apr 7, 2025

Dr. Steven Gundry, a bestselling author and director at the International Heart and Lung Institute, discusses the groundbreaking relationship between the microbiome and mental health. He reveals how gut health influences brain function, affects diseases like depression and Alzheimer's, and introduces concepts like the 'holobiome.' The impact of harmful substances like glyphosate on gut bacteria is explored, along with natural supplements that can aid in restoring gut health for improved mental well-being. A fascinating dive into the gut-brain connection!

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INSIGHT

Brain Microbiome

The brain, previously thought sterile, contains bacteria, as revealed by the Human Microbiome Project.
The project's ability to identify bacterial DNA/RNA led to discoveries in blood and brain.

INSIGHT

Lipopolysaccharides (LPS)

Lipopolysaccharides (LPS), waste products from bacteria, can negatively affect the brain.
LPS, or 'little pieces of [****]', can cross the gut barrier and trigger immune reactions.

INSIGHT

The Holobiome

The holobiome represents the collective microbial communities within the human body.
It emphasizes the interconnectedness of these communities and their combined influence.

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Every year, research reveals new information about the microbiome and its critical role in regulating human health. We know that the microbiome can influence everything from immune health to metabolic health. Today, you’re going to learn about the fascinating new science on the microbiome and the brain. Today’s guest, Dr. Steven Gundry is a bestselling author, the director of the International Heart and Lung Institute, and the founder and director of the Center for Restorative Medicine. His work is focused on curing modern chronic diseases through nutrition. He’s back on The Model Health Show today to share insights from his new book, The Gut-Brain Paradox. In this conversation, you’re going to learn about how the microbiome can influence brain health and mental health. We’re going to cover leaky gut, the holobiome, and how to restore gut health for better health outcomes. I hope you enjoy this interview with the one and only, Dr. Steven Gundry! In this episode you’ll discover:

What we know (and what we don’t know) about the brain microbiome.
How lipopolysaccharides can wreak havoc on the body.
What the holobiome is.
The role the gut plays in diseases.
How bacteria can communicate.
The two ways that calcium can be created in the body.
How macrophages, LPS, and neurogenerative diseases are connected.
Why gut health can influence mental health.
How glyphosate can target happy bacteria in the gut.
What percentage of people are vitamin D deficient.
The critical role that vitamin D plays in gut health.
Why eating prebiotic fiber can transform your health.
How to utilize the powerful combination of prebiotic fiber and fermented foods.
What lectins are.

Items mentioned in this episode include:

Foursigmatic.com/model -- Get an exclusive discount on your daily health elixirs!
Organifi.com/Model  -- Use the coupon code MODEL for 20% off + free shipping!
The Gut-Brain Paradox by Dr. Steven Gundry -- Preorder your copy today!
Connect with Dr. Gundry Website / Podcast / Facebook / Instagram / YouTube

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