Breakpoints

#67 – Nixing the Nidus: Managing Retained Sources in Prosthetic Joint Infections

Nov 25, 2022

01:10:32

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Highlights

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Episode notes

Cipha Droxel vs Cephaloxin

03:42

Biofilm and Retaining Hardware Infections

02:44

The Role of Oral Antibiotics in PJI Surgery

05:23

Introduction

2min

Antibiotic Therapy for Prosthetic Joint Infections

5min

Biofilm and Retaining Hardware Infections

3min

The Pharmacodynamic Killing of Antibiotics in PGI

6min

Oral Versus IV Enochrobials for PGI?

5min

The Static Spacer Is a Surgical Choice

1min

Refampin in TJI?

4min

Is There a Clinically Significant Interaction Between Refampin and a Partner Antibiotic?

2min

Refampin and TB

2min

10.

Is Refampin a Good Choice for Treatment of TB?

2min

11.

Oral Antibiotics for Diabetic Foot Infections

3min

12.

The Role of Suppressive Therapy in PGI

5min

13.

The Role of Oral Antibiotics in PJI Surgery

5min

14.

Do You Think This Is the Right Thing to Be Doing?

2min

15.

Pji and Ortho-Id - What Upcoming Research Are You Most Excited About in This Space?

2min

16.

Quinolone Plus for Vampin Is the Best Combination to Kill Cancer

2min

17.

Side Effects of Low Quinolones in Cystic Fibrosis

6min

18.

Bone and Joint Infection Podcast - I Feel Nerdy

2min

19.

Phototoxic Side Effects of Minisycline

2min

20.

Cipha Droxel vs Cephaloxin

4min

21.

Long-Term Lonese Lid Side Effects

2min

22.

Lonese Lid for Treatment of Uh Pji

3min

Dr. Laura Certain (@laura_certain) and Dr. Nico Cortes-Penfield (@Cortes_Penfield) join Dr. Julie Ann Justo (@julie_justo) to discuss all things related to prosthetic joint infections. Tune in to learn about what comprises a bacterial biofilm, how it develops, and ways to combat it using the latest evidence-based antibiotic regimens. We also take a look at what’s on the horizon for the field of orthopedic infectious diseases.

Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/

References:

Cortés-Penfield NW, Kulkarni PA. The History of Antibiotic Treatment of Osteomyelitis. Open Forum Infect Dis. 2019 Apr 8;6(5):ofz181. doi: 10.1093/ofid/ofz181. PMID: 31123692.
Bernard L, et al. Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection. N Engl J Med. 2021 May 27;384(21):1991-2001. doi: 10.1056/NEJMoa2020198. PMID: 34042388. (DATIPO trial)
Gallagher C, et al. Impact of Implementing an IV to PO Antibiotic Treatment Protocol for Orthopedic Infections ion Prescribing Habits and Health Utilization Outcomes. IDWeek 2022. Poster 909.
Febrile Podcast. Episode #31 – Truth or DAIR. 2022 Feb 28. https://febrilepodcast.com/episode-31-truth-or-dair/
Frank JM, et al. The Mark Coventry, MD, Award: Oral Antibiotics Reduce Reinfection After Two-Stage Exchange: A Multicenter, Randomized Controlled Trial. Clin Orthop Relat Res. 2017 Jan;475(1):56-61. doi: 10.1007/s11999-016-4890-4. PMID: 27387759.
Kelly MP, et al. Extended Oral Antibiotics Increase Bacterial Resistance in Patients Who Fail 2-Stage Exchange for Periprosthetic Joint Infection. J Arthroplasty. 2022 Aug;37(8S):S989-S996. doi: 10.1016/j.arth.2022.01.027. PMID: 35074446.
Payne J, et al. Inducing Antimicrobial Resistance with Long-term Antibiotics at Stage 2 Revision for Periprosthetic Joint Infection. IDWeek 2022. Poster 981.
Frost P, et al. Phototoxic potential of minocycline and doxycycline. Arch Dermatol. 1972 May;105(5):681-3. PMID: 5026677.
Lode H, et al. Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, and CGP 9000. Antimicrob Agents Chemother. 1979 Jul;16(1):1-6. doi: 10.1128/AAC.16.1.1. PMID: 475366.
Sader HS, et al. In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. Diagn Microbiol Infect Dis. 1993 Aug-Sep;17(2):143-50. doi: 10.1016/0732-8893(93)90025-3. PMID: 8243035.
Green S & Tsai YV. Precision Dosing of To-Marrow: Linezolid Therapeutic Drug Monitoring. ContagionLive: Bench to Bedside with SIDP. 2022 Nov 3. https://www.contagionlive.com/view/precision-dosing-of-to-marrow-linezolid-therapeutic-drug-monitoring

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Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints.