Dr. Stephen Cabral discusses biological age vs chronological age, genetic markers, methylation, and the impact of lifestyle choices on aging. Topics include supplements to slow aging, reducing oxidative stress, and balancing health interventions. The conversation explores genetic influences on health outcomes, the role of diet and exercise in aging, and the importance of regular testing for biological age.
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Quick takeaways
Biological age can differ from chronological age, showing how your body ages relative to years.
Advancements in DNA tests improve accuracy in determining markers for faster or slower aging.
Lifestyle changes and targeted protocols can slow aging, reducing health risks and extending lifespan by 20-30%.
Deep dives
Biological Age vs. Chronological Age
Biological age, independent of your chronological age, can be different, indicating how your body is aging compared to your actual years. Through a biological age test, factors like stress and sleep can influence the speed of aging, as seen in participants like Adam, Sal, and Doug.
DNA Methylation and Aging Markers
DNA tests examine methylation points to determine markers for faster or slower aging. Initially, accuracy was a challenge, with tests showing discrepancies of years. However, advancements have reduced this margin to months, aiming for even greater precision in the future.
Health Implications and Biological Age Effects
Biological age tests correlate with health risks like cardiovascular issues, type 2 diabetes, blood pressure, and Alzheimer's risk, providing an epimetabolic index for assessing likelihood of disease development. Lifestyle adjustments and targeted protocols have shown potential to slow aging and extend lifespan by 20-30%.
Mitochondria and Inflammation Balance
Taking antibiotics and experiencing chronic diseases can weaken mitochondria, leading to imbalanced inflammation levels that damage the body. Senescent cells, known as zombie cells, do not undergo cellular death, contributing to increased inflammation, wrinkles, hair loss, and body deterioration. Supplements like NMN and vitamin B3 aid in improving mitochondria function and energy production.
Health Span Factors and Longevity
Factors like stress, sleep, and nutrition play crucial roles in biological aging. Adapting a Mediterranean diet rich in polyphenols and maintaining muscle mass through strength training can reduce cancer risk and improve health span. Activities like brisk walking or zone two cardio for 90 to 150 minutes weekly, along with monitoring biological age through tests like Dr. Steven Horvath's clock, aid in optimizing health and lifespan.
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