Huberman Lab
Dr. Peter Attia: Supplements for Longevity & Their Efficacy
Jul 29, 2024
Dr. Peter Attia, a physician trained at Stanford and Johns Hopkins, shares his expertise on longevity and healthspan. He dives into the NAD pathway and the supplementation debate surrounding NAD, NMN, and NR. Attia evaluates their efficacy and safety while discussing lifestyle factors like sleep, nutrition, and exercise essential for longevity. The conversation also touches on whether biological age tests are accurate indicators of aging and the complex interplay of modern lifestyle habits in preventing disease.
02:30:41
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Quick takeaways
- The NAD pathway plays a crucial role in cellular function and aging, and supplementation with NMN and NR may help replenish NAD levels.
- Current research indicates that while NR shows higher bioavailability, the long-term efficacy of NAD supplements on human longevity remains uncertain.
Deep dives
Introduction to NAD and Longevity
The episode delves into the NAD pathway, a biological process that has garnered significant attention for its potential role in extending lifespan and healthspan. NAD, or nicotinamide adenine dinucleotide, is crucial for cellular function and energy production, and its levels decrease with age. The hosts discuss how various supplements like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are thought to replenish NAD levels, thereby attempting to mitigate age-related decline. They also explore the biochemical and experimental supports for the efficacy of these supplements in enhancing longevity.
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