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Dr. Peter Attia: Supplements for Longevity & Their Efficacy

Huberman Lab

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Caloric Restriction and Sirtuins: Unpacking Longevity

This chapter examines the paradox of caloric restriction's impact on health and longevity, highlighting its potential health risks and complex relationship with sirtuins. It discusses the genetic manipulation of specific mouse models to explore the effects of sirtuins on lifespan, revealing sex-specific differences in outcomes. The chapter further critiques the efficacy of resveratrol as a sirtuin activator, emphasizing the need for rigorous scientific validation of longevity claims.

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