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Siim Land Podcast

#372 Glycine and Protein for Longevity; Genetic Bottlenecks and MTHFR - Chris Masterjohn PhD

Aug 22, 2023
Chris Masterjohn, longevity and genetics expert, discusses the role of glycine and methionine in promoting longevity. They explore the risks of high homocysteine, optimal protein ratios, and the benefits of taurine supplementation. They also delve into the importance of identifying genetic bottlenecks for optimal performance and longevity. The podcast concludes with strategies for longevity, self-experimentation, and the potential for reversing biological aging.
01:18:35

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Quick takeaways

  • Maintaining a balance between sulfur amino acids (methionine and cysteine) and glycine is vital for longevity.
  • Balancing collagen-rich animal proteins with glycine is important for overall health.

Deep dives

Importance of Understanding Metabolic Bottlenecks

Understanding individual metabolic bottlenecks in your metabolism can provide valuable insights for achieving a longer and healthier life. Focusing on longevity alone may overlook the importance of preventing specific causes of death. Heart disease and cancer are the leading causes of death, but it is crucial to prioritize protection against physical injury and other health issues that could impact longevity. Maintaining high-quality bone mass and muscle mass is essential, especially to prevent falls and fractures. Achieving a balance between sulfur amino acids (methionine and cysteine) and glycine is vital for longevity. Methionine influx can deplete glycine, which affects various aspects of health, including sleep, detoxification, blood sugar regulation, and collagen synthesis. Finding the right balance between protein intake and collagen-rich animal proteins can support overall body composition and health.

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