In this episode, Chris Masterjohn, entrepreneur, independent researcher, and doctorate in nutrition, elucidates the latest research on the risk and benefits of NAD supplements, and shares his personal intuition on the topic. We also dive deep into choline deficiency and its role in the rising prevalence of nonalcoholic fatty liver disease. From there, Chris enlightens us on the importance of methylation, a simple yet profoundly important biochemical process affecting our physical and mental health. He also describes the variations of the genes MTHFR and COMT, enzymes which play important roles in methylation and which have profound impacts on our well-being.   We discuss: Chris’s background, falling in love with biochemistry, and decision to pursue research over medicine [7:45]; Choline: what it is, why it is important, and how a deficiency can cause non-alcoholic fatty liver disease [11:45]; NAFLD: increasing prevalence and potential causes [25:00]; TMAO: Should we be worried about the TMAO content in choline and our foods? [39:15]; Types of fatty acids: How they may predispose us to different types of illnesses [53:30]; Why don’t we see low VLDL in patients with NAFLD? [59:45]; Understanding flux, and how machine learning may affect medicine in the near future [1:03:15]; NAD: How it works, supplements, sirtuins, and the central role of the liver [1:09:30]; Intravenous NAD [1:33:00]; Oral NR: Is it the optimal way to get more NAD? [1:38:30]; What is the possible harm of taking an NAD precursor? [1:47:15]; The MTHFR gene [1:49:45]; The methylation pathway [1:58:15]; The COMT gene [2:04:30]; Creatine: The uses and benefits and its important role in methylation [2:10:15]; Dietary strategies for MTHFR: choline, creatine, folate, and glycine [2:16:45]; How to mitigate the negative effects of NAD supplements [2:23:45]; A case study of a person with high homocysteine [2:28:00]; What is the level of evidence that you need to take action? [2:32:15]; Does Chris supplement with NAD precursors? And can it improve symptoms of rosacea? [2:35:45]; Decision making in the face of inconclusive data, and trying to disentangle the placebo effect [2:39:00]; What does Chris believe to be true that very few people would agree with him about? [2:43:15]; How to follow Chris’s work [2:48:45]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

In this episode, Chris Masterjohn, entrepreneur, independent researcher, and doctorate in nutrition, elucidates the latest research on the risk and benefits of NAD supplements, and shares his personal intuition on the topic. We also dive deep into choline deficiency and its role in the rising prevalence of nonalcoholic fatty liver disease. From there, Chris enlightens us on the importance of methylation, a simple yet profoundly important biochemical process affecting our physical and mental health. He also describes the variations of the genes MTHFR and COMT, enzymes which play important roles in methylation and which have profound impacts on our well-being.   We discuss: Chris’s background, falling in love with biochemistry, and decision to pursue research over medicine [7:45]; Choline: what it is, why it is important, and how a deficiency can cause non-alcoholic fatty liver disease [11:45]; NAFLD: increasing prevalence and potential causes [25:00]; TMAO: Should we be worried about the TMAO content in choline and our foods? [39:15]; Types of fatty acids: How they may predispose us to different types of illnesses [53:30]; Why don’t we see low VLDL in patients with NAFLD? [59:45]; Understanding flux, and how machine learning may affect medicine in the near future [1:03:15]; NAD: How it works, supplements, sirtuins, and the central role of the liver [1:09:30]; Intravenous NAD [1:33:00]; Oral NR: Is it the optimal way to get more NAD? [1:38:30]; What is the possible harm of taking an NAD precursor? [1:47:15]; The MTHFR gene [1:49:45]; The methylation pathway [1:58:15]; The COMT gene [2:04:30]; Creatine: The uses and benefits and its important role in methylation [2:10:15]; Dietary strategies for MTHFR: choline, creatine, folate, and glycine [2:16:45]; How to mitigate the negative effects of NAD supplements [2:23:45]; A case study of a person with high homocysteine [2:28:00]; What is the level of evidence that you need to take action? [2:32:15]; Does Chris supplement with NAD precursors? And can it improve symptoms of rosacea? [2:35:45]; Decision making in the face of inconclusive data, and trying to disentangle the placebo effect [2:39:00]; What does Chris believe to be true that very few people would agree with him about? [2:43:15]; How to follow Chris’s work [2:48:45]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Chris Masterjohn, longevity and genetics expert, discusses the role of glycine and methionine in promoting longevity. They explore the risks of high homocysteine, optimal protein ratios, and the benefits of taurine supplementation. They also delve into the importance of identifying genetic bottlenecks for optimal performance and longevity. The podcast concludes with strategies for longevity, self-experimentation, and the potential for reversing biological aging.

What are some steps that you can take to boost your immune system so that you can stop getting sick? What if you just started feeling some symptoms, are there specific supplements that will stop the sickness dead in its tracks? Dr. Chris Masterjohn is back on the podcast to outline his Ultimate Cold Prevention Protocol! In this episode, Chris and Joe go through all of Chris’ prevention protocol - starting with what to do to strengthen your immune system, to your action plan when you first experience the “suspicous sneeze”, to what different vitamins and minerals you should focus on when you’ve been infected. Chris also discusses the importance of understanding scientific studies (it’s more than just looking at charts), the difference between focusing on deficiencies vs. optimization, and his thoughts on alternative health tests like organic acids and dutch tests. Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health. - Find Chris on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (1:00) - Chris’ thoughts on functional tests (23:52) - Deficiency vs. Optimization (29:30) - The immune system (35:34) - The cold prevention protocol (41:58) - The importance of understanding studies (44:53) - Explaining Vitamin D (48:59) - Continuing the cold prevention protocol (56:07) - Nutrients for immunity (1:07) - Glutathione

Chris Masterjohn holds a PhD in Nutritional Sciences from the University of Connecticut, having completed his degree in 2012. He later worked as a postdoctoral research associate in the Comparative Biosciences department of the College of Veterinary Medicine at the University of Illinois at Urbana-Champaign for two years until August 2014. Afterward, he served as an Assistant Professor of Health and Nutrition Sciences at Brooklyn College for two years, part of the City University of New York. Chris then made the decision to leave academia in the fall of 2016 and pursue entrepreneurship. Since January 2017, he has been conducting independent research, consulting, working on information products, and producing free content to help people achieve better health. Chris has a deep understanding of the power of food, movement, and mindfulness in promoting health and well-being, and translates complex science into practical principles that people can use to support their health.In this episode we discussThe optimal human diet.Do protein and red meat cause cancer and disease?How to meet your long-term health goals with nutrition.What do lab tests really tell you about your health?This episode is brought to you by Better Help, LMNT, Inside Tracker, 1stPhormSubscribe to Chris' newsletterMentioned in this episode:10% off your first month of online therapy with BetterHelphttps://betterhelp.com/drlyonGet your free LMNT Sample Pack with any purchasehttps://drinklmnt.com/drlyonInside Tracker 20% Off the Entire Storehttps://info.insidetracker.com/drlyonVisit 1st Phorm Website for Free Shippinghttp://www.1stphorm.com/drlyon

Copper! Copper is needed to prevent anemia, histamine intolerance, high cholesterol, and osteoporosis, probably helps with allergies, and is needed to make you feel good overall. There’s a dark side to its toxicity, but more likely you need more copper than less. Tune in for everything you need to know about how to manage your copper status! This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 These links are mentioned in the episode: Zinc for heavy metals: https://chrismasterjohnphd.com/2018/11/01/zinc-heavy-metals/ The methylation page: https://chrismasterjohnphd.com/methylation Here’s a much more detailed page about copper: https://chrismasterjohnphd.com/2017/02/03/manage-copper-status/ Access the show notes, transcript, and comments here.

How important is it for you to test and track your lab markers? Are some tests more important than others? Are functional lab tests useless, or is it just the way that companies are interpreting the data that renders it useless? In this eye-opening episode, we brought on Dr. Chris Masterjohn and Dr. Tommy Wood to dive deep into understanding the complexities of test results, vitamin and mineral deficiencies, and genetic predispositions. Chris and Tommy use their years of expertise and tremendous depths of knowledge in the health space to discuss the issues with alternative health tests and the best ways to utilize your DNA results. They also discuss the effects of deficiencies on essential nutrients like zinc and how you can take control of your well-being by identifying unique deficiencies about your own body. Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health. Dr. Tommy Wood is an MD with a Ph.D. in physiology and neuroscience. He has coached world-class athletes and is currently an Assistant Professor of Pediatrics and Neuroscience at the University of Washington. - Find Dr. Tommy Wood on Instagram - Find Chris on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Intro (9:58) - Repeatability in testing (18:28) - Validity of urine hormone testing (31:00) - Chris’ thoughts on organic acids tests (39:03) - Validity of organic acids tests (43:52) - Fungal & yeast tests (47:11) - Going over relevancy of some markers (54:25) - Polygenic Risk Scoring (1:00:47) - Nutritional Markers (1:05:20) - Neurotransmitter Markers (1:07:10) - Stool IgA Tests (1:12:10) - Ion Amino Acids Panel (1:16:51) - Summarizing functional lab tests

Dr. Spencer Nadolsky, a family and obesity medicine physician, joins obesity researcher Stephen Guyenet, nutritional scientist Chris Masterjohn, and exercise physiologist Brad Dieter for an enlightening discussion on saturated fat. They explore its controversial role in heart health and chronic diseases, emphasizing how dietary context influences its impacts. The panel highlights the importance of overall dietary patterns over specific fatty acids and advocates for personalized approaches in nutrition. Expect to rethink saturated fat’s implications on appetite, metabolism, and overall health!

Episode Highlights With ChrisWhat biotin is and why it is important in the bodyImportant things to understand about supplemental biotin and what to look forHigh dose biotin supplementation- why people are doing this and what is considered a high dosePros and cons of biotin supplementationThe biotin candida connectionBig problems connected to biotin deficiencyHow to actually get enough biotin from food and when supplements are a good ideaWays to figure out how much biotin you actually need: serum biotin testing and functional marker testingWhat you need to know about sodiumA tip for diarrhea: salted riceSodium and glucose keep water in the blood and why this is importantHow potassium comes into play here as wellDopamine synthesis is dependent on sodiumWhen supplementing with salt is helpfulOnly 6% of your average salt intake comes from what was added at the table, and almost all of it comes from processed foodsThe real deal on if exercise and sauna use increase sodium needIf you eat a whole food diet you might need more saltFood sources of potassium and how to get enough (hint: you aren’t getting enough from bananas)The real deal on Omega-3s and Omega-6sMore reasons to incorporate liver, egg yolks and fatty fish into your dietResources We MentionChris Masterjohn - websiteChris Masterjohn - InstagramLMNTThanks to Our Sponsors:HigherDOSE - Check out their sauna blanket, PEMF mat, red light face mask and so much more! I use their PEMF mat several times during the week. Use code mama15 for a discount.LMNT - My go-to electrolyte mix that I use during workouts, while fasting and in the sauna. It's a clean source of all of your electrolyte needs.

Chris Masterjohn PhD discusses the importance of choline as an essential nutrient, its role in reducing fatty liver, dietary sources, and methylation. He emphasizes the necessity of sufficient choline intake, especially during pregnancy. The podcast also tackles the TMAO controversy, optimizing folate status, and addressing MTHFR SNPs with creatine, B2, choline, and glycine.