Siim Land Podcast

Explore the complexities of elite sports and their paradoxical health effects. Discover the optimal protein intake for longevity and the debate over methionine's impact on lifespan. Dive into the fascinating world of topical versus oral supplement delivery, including skin benefits. Learn about maintaining youthful testosterone levels and the importance of cycling supplements. Siim shares effective red light therapy practices and strategies to combat air pollution, while also revealing his ultimate supplement stack for health.

Jon Berner, MD PhD, a Seattle-based psychiatrist and lithium researcher, delves into why lithium could be a revolutionary longevity molecule. He discusses how low doses might reduce dementia and suicidality, and the fascinating mechanisms behind its effects on mTOR and autophagy. Berner shares insights on the optimal dosing, safety concerns, and personal experiences with lithium. He also touches on the potential benefits for those with bipolar traits and explores the synergy between lithium and rapamycin, all while advocating for personalized treatment approaches.

Yip Tszho (Zico), Chief Executive of Lonvi Biosciences and a pioneer in longevity research, dives into the groundbreaking development of PCC1, a senolytic pill aimed at extending human lifespans. He explains how PCC1 selectively targets and eliminates senescent cells, possibly increasing lifespan by 9.4% in studies. The conversation explores the potential health benefits of this drug, including improved immune response and skin health. Yip also shares insights on the future of Chinese longevity science and the importance of biomarker-driven treatments.

Brady Holmer, a science writer and researcher with a Master's in Human Performance, dives into the benefits of heat acclimation and sauna use for fitness and longevity. He discusses how heat exposure can enhance performance, emphasizing its unique recovery properties and potential to improve VO2 max. Brady explores the optimal frequency and duration of sauna sessions, the impact on cardiovascular health, and offers insights on cold exposure. He also highlights the importance of hydration and the intriguing links between sauna use and longevity.

Join longevity educator Siim Land and Dr. Joy Kong as they delve into the fascinating world of longevity testing. Siim shares insights on important health metrics like VO2 Max, blood tests, and hormone testing, emphasizing the significance of actionable results. They also discuss innovative topics such as microbiome assessments, the impact of microplastics, and the limitations of food sensitivity testing. Siim highlights the value of comprehensive health retreats, incorporating advanced screenings and therapies for optimizing overall well-being.

Dr. Mark Tarnopolsky, a mitochondrial expert and Professor at McMaster University, shares fascinating insights on aging and longevity. He explains how mitochondria influence health, detailing the role of oxidative stress and exercise in longevity. Mark advocates for endurance training as the most effective way to extend lifespan and discusses the benefits of tailored antioxidant combinations. He also emphasizes the importance of nutrition for mitochondrial health and offers intriguing perspectives on resistance training and supplementation.

Dr. Tyler Panzner, a physician and genetics expert, delves into the fascinating world of longevity genes and what centenarians can teach us. He breaks down the genetics of a 117-year-old woman, exploring resilience, immunity, and the surprising protective role of short telomeres. The conversation touches on the FOXO3 gene's link to stress resilience and discusses gene editing, the risks of telomerase activation, and how genetics can personalize longevity strategies. Panzner emphasizes the importance of integrating genetic insights for tailored health interventions.

In this engaging discussion, Siim Land, an Estonian biohacker and longevity coach, delves into the fascinating world of life extension. He shares insights on the importance of diet diversity and personal biomarkers, emphasizing that one-size-fits-all diets are outdated. Siim cautions against trendy substances like rapamycin and discusses a recent FOXO3A study that hints at reversing biological aging. He also explores the balance between mental well-being and physical health, while speculating on the future of genetic enhancements and the realistic odds of attaining immortality.

Dive into the fascinating world of health insights, where the impact of exercise on inflammation is explored. Discover the intriguing research on melatonin megadosing and its gaps in clinical evidence. The podcast compares popular supplement brands and reveals the true value of Urolithin A. Caffeine's effects on brain aging are discussed, alongside sleep debt strategies that suggest catch-up sleep can help. Finally, learn about cultivating a healthy relationship with food that appreciates occasional indulgences.

Dive into the world of longevity supplements with a ranking from best to worst! Discover how taurine can enhance metabolic health and the mixed evidence surrounding metformin. Learn about the potential of omega-3s for heart health and why glycine is considered a safe longevity win. Siim unpacks the roles of resveratrol, curcumin, and NAC, while critically assessing the impact of vitamins and herbal extracts. From joint support supplements to the role of lithium in water, this discussion offers a deep dive into what could help extend your lifespan!