Siim Land Podcast

Dr. Mark Tarnopolsky, a mitochondrial expert and Professor at McMaster University, shares fascinating insights on aging and longevity. He explains how mitochondria influence health, detailing the role of oxidative stress and exercise in longevity. Mark advocates for endurance training as the most effective way to extend lifespan and discusses the benefits of tailored antioxidant combinations. He also emphasizes the importance of nutrition for mitochondrial health and offers intriguing perspectives on resistance training and supplementation.

Dr. Tyler Panzner, a physician and genetics expert, delves into the fascinating world of longevity genes and what centenarians can teach us. He breaks down the genetics of a 117-year-old woman, exploring resilience, immunity, and the surprising protective role of short telomeres. The conversation touches on the FOXO3 gene's link to stress resilience and discusses gene editing, the risks of telomerase activation, and how genetics can personalize longevity strategies. Panzner emphasizes the importance of integrating genetic insights for tailored health interventions.

In this engaging discussion, Siim Land, an Estonian biohacker and longevity coach, delves into the fascinating world of life extension. He shares insights on the importance of diet diversity and personal biomarkers, emphasizing that one-size-fits-all diets are outdated. Siim cautions against trendy substances like rapamycin and discusses a recent FOXO3A study that hints at reversing biological aging. He also explores the balance between mental well-being and physical health, while speculating on the future of genetic enhancements and the realistic odds of attaining immortality.

Dive into the fascinating world of health insights, where the impact of exercise on inflammation is explored. Discover the intriguing research on melatonin megadosing and its gaps in clinical evidence. The podcast compares popular supplement brands and reveals the true value of Urolithin A. Caffeine's effects on brain aging are discussed, alongside sleep debt strategies that suggest catch-up sleep can help. Finally, learn about cultivating a healthy relationship with food that appreciates occasional indulgences.

Dive into the world of longevity supplements with a ranking from best to worst! Discover how taurine can enhance metabolic health and the mixed evidence surrounding metformin. Learn about the potential of omega-3s for heart health and why glycine is considered a safe longevity win. Siim unpacks the roles of resveratrol, curcumin, and NAC, while critically assessing the impact of vitamins and herbal extracts. From joint support supplements to the role of lithium in water, this discussion offers a deep dive into what could help extend your lifespan!

Chris Dancy is called 'the most connected man on Earth' because of his pioneering use of technology in everyday life and health optimization.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:23 Why Chris is the most connected man on earth03:38 How Chris used technology to lose weight and get healthy08:43 How technology changes the human experience in the future10:43 Best tools 16:28 The technology Renaissance period20:43 Bon Charge sponsorship21:38 Implants24:18 Hacking time33:28 Meditation and mindfulness36:48 Does time go by faster if you’re stuck in daily routines47:38 How Chris’ perception of time has changed as he got older52:43 Will virtual reality extend perception of lifespan59:03 How to make technology better for your healthChris Dancy website: https://www.chrisdancy.com/

Josh Mitteldorf, PhD, is a physicist turned aging researcher and the author of "Cracking the Aging Code." He explores why aging may be a programmed process shaped by evolution, diving into concepts like caloric restriction, telomere shortening, and altruistic cell death. Mitteldorf discusses species that exhibit negligible aging, the role of insulin in lifespan, and the potential of exosomes for rejuvenation. He also touches on the ethical implications of life extension and shares practical longevity tips, offering a fascinating glimpse into controlling our biological clock.

Get my free bloodwork cheat sheet: https://www.siimland.co/bloodwork-cheat-sheetTimestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who dives into the fascinating science of our body's internal clocks and their impact on aging. He discusses how circadian clock dysfunction contributes to age-related changes and highlights the connection between genetic factors and longevity. Potter explains the effects of shift work, artificial light, and the benefits of aligning with your natural rhythms. He also delves into the role of melatonin and offers tips for optimizing morning routines to promote health as we age.

Dr. Paul Robbins, a leading researcher in aging and biochemistry at the University of Minnesota, dives into cellular senescence and its fascinating role in aging. He discusses the promising benefits of eliminating senescent cells for health and lifespan extension. The conversation covers groundbreaking senolytic therapies, gene therapies, and lifestyle strategies to enhance well-being as we age. Robbins also tackles the potential of compounds like rapamycin and the importance of immune function in longevity, making a compelling case for innovations in anti-aging research.