Siim Land Podcast

Josh Mitteldorf, PhD, is a physicist turned aging researcher and the author of "Cracking the Aging Code." He explores why aging may be a programmed process shaped by evolution, diving into concepts like caloric restriction, telomere shortening, and altruistic cell death. Mitteldorf discusses species that exhibit negligible aging, the role of insulin in lifespan, and the potential of exosomes for rejuvenation. He also touches on the ethical implications of life extension and shares practical longevity tips, offering a fascinating glimpse into controlling our biological clock.

Get my free bloodwork cheat sheet: https://www.siimland.co/bloodwork-cheat-sheetTimestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who dives into the fascinating science of our body's internal clocks and their impact on aging. He discusses how circadian clock dysfunction contributes to age-related changes and highlights the connection between genetic factors and longevity. Potter explains the effects of shift work, artificial light, and the benefits of aligning with your natural rhythms. He also delves into the role of melatonin and offers tips for optimizing morning routines to promote health as we age.

Dr. Paul Robbins, a leading researcher in aging and biochemistry at the University of Minnesota, dives into cellular senescence and its fascinating role in aging. He discusses the promising benefits of eliminating senescent cells for health and lifespan extension. The conversation covers groundbreaking senolytic therapies, gene therapies, and lifestyle strategies to enhance well-being as we age. Robbins also tackles the potential of compounds like rapamycin and the importance of immune function in longevity, making a compelling case for innovations in anti-aging research.

In this engaging discussion, Greg Potter, a nutrition expert and Chief Science Officer at a supplement startup, dives into the intriguing relationship between diet and longevity. He emphasizes the importance of what, how much, and when we eat, revealing how meal timing can significantly affect metabolic health. Potter contrasts low-carb and plant-based diets, advocating for personalized nutrition strategies tailored to individual needs. Their conversation sheds light on the role of protein in overall well-being and tackles nutrition misinformation in the age of social media.

The discussion delves into a detailed comparative analysis of health biomarkers between two individuals. It highlights intriguing differences in fitness, body composition, and metabolic health. Listeners will learn about inflammation and immune markers, alongside cardiovascular and kidney health indicators. The conversation also touches on hormone levels and experimental tests for longevity. Plus, a fascinating look at the PhenoAge biological age test adds depth to the exploration of how one can rewind their biological clock.

Dive into a detailed ranking of over 100 supplements for 2025, from the highly praised methylated B vitamins to the controversial resveratrol. Discover the health benefits of intriguing options like sulforaphane, ashwagandha, and NAC. The evaluation covers efficacy, risks, and specific populations who might benefit most. Plus, learn about the importance of probiotics tailored to individual gut health. Unpack which supplements truly stand out for longevity and metabolic support.

Dr. Joe Zundell, a dedicated cancer biologist, delves into groundbreaking cancer research and innovations in treatment. He discusses how lifestyle choices, such as exercise and stress management, significantly influence cancer risks. The impact of environmental toxins is examined, including how living near golf courses may elevate health risks. Zundell elaborates on early cancer detection and the essential differentiation between benign and malignant tumors, while also addressing the potential role of certain supplements in cancer prevention.

Greg Potter, PhD, an expert in sleep and nutrition, and Nicolas Verhoeven, PhD, a specialist in exercise physiology, discuss the vital role of exercise in health. They explore the dangers of a sedentary lifestyle and how varying exercises combat chronic diseases. The conversation touches on the importance of VO2 max for longevity, the balance between cardio and resistance training, and humorous workout mishaps. Listeners will appreciate practical advice on personalized fitness routines and the significance of integrating movement into daily life.

Dr. Anil Bajnath, a physician specializing in precision medicine and detoxification, dives deep into the science behind detoxing. He discusses how the body naturally detoxifies and the crucial roles of sweating and hydration in this process. Anil busts myths about detox scams and emphasizes the need for a holistic approach beyond just the liver. He shares insights on supplements, gut health, and practical detox strategies tailored to combat modern toxins, including mold and microplastics, providing listeners with actionable advice for better health.