Siim Land Podcast #469 Latest Research About Reversing Aging Cells - Dr Paul Robbins, PhD
Sep 5, 2025
Dr. Paul Robbins, a leading researcher in aging and biochemistry at the University of Minnesota, dives into cellular senescence and its fascinating role in aging. He discusses the promising benefits of eliminating senescent cells for health and lifespan extension. The conversation covers groundbreaking senolytic therapies, gene therapies, and lifestyle strategies to enhance well-being as we age. Robbins also tackles the potential of compounds like rapamycin and the importance of immune function in longevity, making a compelling case for innovations in anti-aging research.
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What Cellular Senescence Is
- Senescent cells exit the cell cycle after damage and often secrete inflammatory factors that recruit immune clearance.
- When immune clearance fails with age, accumulated senescent cells drive chronic inflammation and age-related pathologies.
Senescence Protects But Backfires
- Senescence evolved as an anti-tumor mechanism that forces damaged or oncogene-activated cells out of the cell cycle.
- That protective benefit becomes harmful when senescent cells accumulate and chronically promote inflammation.
Prioritize Healthspan Over Longevity
- Aim to compress morbidity so people stay healthy longer and decline quickly only at the end of life.
- Prioritize interventions that extend healthspan rather than solely increasing total lifespan.