Siim Land Podcast #475 Q&A: Biggest things that contribute to my health, does caffeine age the brain, can you make up for lost sleep and more
Oct 18, 2025
Dive into the fascinating world of health insights, where the impact of exercise on inflammation is explored. Discover the intriguing research on melatonin megadosing and its gaps in clinical evidence. The podcast compares popular supplement brands and reveals the true value of Urolithin A. Caffeine's effects on brain aging are discussed, alongside sleep debt strategies that suggest catch-up sleep can help. Finally, learn about cultivating a healthy relationship with food that appreciates occasional indulgences.
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Acute Stress From Exercise Is Beneficial
- Exercise raises inflammation and oxidative stress acutely but lowers baseline inflammation long-term.
- Regular training increases endogenous antioxidant capacity and improves resting biomarkers.
Take Saunas To Boost Recovery
- Use sauna after vigorous training to boost recovery, reduce inflammation, and lower respiratory infection risk.
- Regular sauna plus exercise can improve VO2 max and lower resting blood pressure more than exercise alone.
Be Cautious With Melatonin Megadoses
- Consider melatonin megadosing only experimentally and with caution because clinical trials are lacking.
- Siim Land has self-tested doses up to 10 mg and plans higher trials but notes evidence is limited.