Siim Land Podcast #477 The Science of Longevity Genes: What We’ve Learned from Centenarians - Dr Tyler Panzner
Oct 31, 2025
Dr. Tyler Panzner, a physician and genetics expert, delves into the fascinating world of longevity genes and what centenarians can teach us. He breaks down the genetics of a 117-year-old woman, exploring resilience, immunity, and the surprising protective role of short telomeres. The conversation touches on the FOXO3 gene's link to stress resilience and discusses gene editing, the risks of telomerase activation, and how genetics can personalize longevity strategies. Panzner emphasizes the importance of integrating genetic insights for tailored health interventions.
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Longevity Is Multi‑Layered Biology
- Multi-omics layers (genomics, transcriptomics, proteomics, exposomics) combine to shape longevity rather than any single measure.
- Tyler Panzner emphasizes genetics is one chapter in a larger biological book affecting lifespan.
Short Telomeres Can Be Protective
- Short telomeres can limit cell and cancer replication, potentially protecting very old individuals from cancer growth.
- Tyler suggests a tipping point where eroded telomeres reduce cancer expansion in the extremely aged.
Cell Adhesion Affects Immune Surveillance
- Mutations in cell adhesion molecules may enhance immune presentation and cancer surveillance.
- Tyler links altered adhesion genes to better immunological synapse formation and immune priming.