Siim Land Podcast #474 Longevity Supplements Ranked From Best to Worst
Oct 10, 2025
Dive into the world of longevity supplements with a ranking from best to worst! Discover how taurine can enhance metabolic health and the mixed evidence surrounding metformin. Learn about the potential of omega-3s for heart health and why glycine is considered a safe longevity win. Siim unpacks the roles of resveratrol, curcumin, and NAC, while critically assessing the impact of vitamins and herbal extracts. From joint support supplements to the role of lithium in water, this discussion offers a deep dive into what could help extend your lifespan!
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Taurine Shows Promising Cross‑Species Benefits
- Taurine extends lifespan in mice and improves metabolic and exercise markers in human trials.
- Siim Land ranks it as a strong, safe longevity candidate based on animal and human data.
Apigenin Helps Preserve NAD Levels
- Apigenin inhibits CD38 and supports NAD metabolism but lacks lifespan data in animals.
- Siim Land considers it an OK component of long‑term NAD support in a longevity stack.
Resveratrol's Benefits Are Contextual
- Resveratrol extends lifespan only in obese/metabolic‑syndrome mice and helps humans with metabolic disease.
- Siim Land warns it may blunt exercise adaptations and places it in a low tier for healthy people.