Siim Land Podcast #470 The New Science Linking Your Body Clock to Longevity - Greg Potter PhD
Sep 12, 2025
Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who dives into the fascinating science of our body's internal clocks and their impact on aging. He discusses how circadian clock dysfunction contributes to age-related changes and highlights the connection between genetic factors and longevity. Potter explains the effects of shift work, artificial light, and the benefits of aligning with your natural rhythms. He also delves into the role of melatonin and offers tips for optimizing morning routines to promote health as we age.
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Hallmarks Are Helpful But Imperfect
- The Hallmarks of Aging are a useful but imperfect, non-systematic framework shaped by researchers' interests.
- Some hallmarks like chronic inflammation and genomic instability have stronger evidence than others.
Clock Dysfunction Alters Aging Trajectory
- Disrupting core clock genes in animals shortens lifespan and causes age-like phenotypes such as sarcopenia and hair loss.
- Both endogenous (genetic, blindness) and exogenous (shift work, jet lag) clock disruptions accelerate aging-related disease risk.
Minimize Circadian Misalignment
- Avoid chronic circadian misalignment like irregular light, meal, and activity timing to reduce disease risks.
- If you must do shift work, maintain consistent meal timing and regular routines to minimize internal misalignment.