The mindbodygreen Podcast 614: The science behind NAD, longevity, & metabolic health | Andrew Salzman, M.D.
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Sep 7, 2025 
Andrew Salzman, M.D., a physician and biomedical entrepreneur, dives deep into the world of NAD, highlighting its critical role in metabolic health and aging. He explains when NAD levels decline and how to assess them. The conversation covers the powerful connection between NAD and menopause, lifestyle impacts, and the benefits of NMN supplements. Salzman also shares insights on safe dosages, supports for NAD enhancement, and emerging research that promises to reshape our understanding of health and longevity in the coming years.
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NAD Is The Metabolic Maestro
- NAD is the central orchestrator of cellular metabolism, energy production, DNA repair, and cognition.
- Declining NAD with age likely drives many features of aging across organs and functions.
NAD Starts Falling In Your 20s
- NAD levels begin to decline in the early 20s and fall substantially by middle age.
- By the 60s you can lose roughly half of your NAD compared with youth.
Support NAD With Diet And Exercise
- Eat a balanced diet containing tryptophan-rich foods like eggs, fish, and broccoli to supply NAD precursors.
- Exercise regularly to stimulate muscle mitochondrial NAD production, but expect some age-related decline regardless.
