The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
165 snips
Jul 18, 2025 • 46min
The Fastest-Acting Nootropic I’ve Ever Used : 1303
Nayan Patel, a distinguished pharmacist and formulator with over 20 years in functional medicine, shares groundbreaking insights into topical glutathione delivery. He reveals how this innovative approach can raise intracellular glutathione levels in just 60 seconds, outperforming traditional methods. The conversation dives into glutathione's role in boosting brain health, enhancing emotional resilience, and revolutionizing immunity. With practical applications for detox and performance optimization, this breakthrough could change how we approach longevity and cellular health.
138 snips
Jul 17, 2025 • 54min
Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway) : 1302
Join Dr. Nathan Bryan, a leading expert in nitric oxide biochemistry, as he uncovers the secrets of this crucial molecule that boosts blood flow, metabolism, and cognitive function. Discover why nitric oxide is essential for optimizing health, sexual performance, and longevity. He reveals why most supplements fail and how common lifestyle choices impair its production. Learn about the connection between nitric oxide, diet, and effective strategies to enhance overall well-being, including the potential downsides of statins and the significance of oral health.
97 snips
Jul 15, 2025 • 50min
Easy Oxygen Hacking for Mitochondria (The 15-Minute Upgrade) : 1301
Join Brad Pitzele, founder of One Thousand Roads and creator of the LEO System, as he shares his journey from a near-fatal autoimmune illness to health rejuvenation through oxygen-based biohacking. Discover how just 15 minutes of Exercise with Oxygen Therapy (EWOT) can transform metabolism and combat chronic conditions. He explains how this method activates neuroplasticity and boosts energy levels, making it accessible for both athletes and those facing chronic issues. Tune in for insights on optimizing mitochondrial health and enhancing overall performance!
34 snips
Jul 10, 2025 • 57min
Facelifts, Breast Implants, and the REAL Fix for Wrinkles : 1300
Dr. Victor Urzola, a renowned Costa Rican plastic surgeon, explores the hidden mechanics of aging and skin health. He uncovers how stem cells and advanced procedures can rejuvenate skin, while discussing the risks associated with breast implants, including hormonal and neurological issues. The conversation delves into the science of inflammation related to implants and the benefits of explant surgery. Urzola emphasizes personalized skincare strategies, innovative technologies, and the interplay between cosmetic procedures and overall health.
140 snips
Jul 8, 2025 • 1h 18min
Superintelligence, Transhumanism & Biohacking in 2027 : 1299
Soren Gordhamer, founder of Wisdom 2.0 and advisor to leaders at OpenAI and Google, joins the conversation to discuss the rapidly approaching era of superintelligence. He emphasizes the need for balancing technology with emotional well-being, offers biohacking strategies for enhancing cognitive health, and reflects on parenting in a tech-centric world. The dialogue also navigates the complexities of human-AI relationships, advocating for community and mindfulness as essential tools for thriving amidst AI advancements.
215 snips
Jul 3, 2025 • 31min
Why I Add Creatine to My Coffee Every Morning (And You Should Too) : 1298
Creatine is more than a bodybuilding supplement; it's a key player in brain optimization and overall health. It boosts cognitive function, enhances memory, and supports mood regulation. Discover its benefits for mitochondrial energy and fetal brain development, as well as its role in longevity. Learn effective dosage strategies and how to enhance absorption with various combinations, including caffeine. This discussion dives deep into the science, debunking myths and revealing effective ways to integrate creatine into your daily routine for optimal performance.
89 snips
Jul 1, 2025 • 57min
Death, Legacy & the Philosophy of Longevity — with Stephen Cave : 1297
Join Stephen Cave, a philosopher and best-selling author, as he dives deep into the philosophical and ethical implications of longevity and death. Explore how biohacking is challenging our understanding of mortality and legacy. Discuss the four immortality narratives and the dangers of mind uploading. Reflect on how AI could reshape humanity’s future—either as a god or destroyer. Unpack the societal consequences of living longer lives, and why embracing mortality might actually enrich our experiences in the here and now.
133 snips
Jun 27, 2025 • 46min
Fix What’s Making You Feel Old—From Joints to Mitochondria | Dr. Greg Kelly : 1296
Greg Kelly, SVP of Product Development at Qualia Life, is an expert in functional medicine and anti-aging science. In the conversation, he reveals fascinating insights on reversing joint pain, emphasizing that it's often linked to metabolic issues rather than aging. Kelly discusses how gut health impacts joint function and introduces unconventional supplements like tamarind seed extract and eggshell membrane. He also covers the importance of sleep and nutrition in optimizing recovery, alongside cutting-edge techniques for enhancing joint health and longevity.
123 snips
Jun 26, 2025 • 1h 6min
The Ultimate Guide to a Metabolism That Burns Fat Again — with Ben Azadi : 1295
Ben Azadi, a functional health expert and best-selling author, joins to unpack the shocking reality that 93% of people are metabolically unhealthy. They dive into how high insulin levels—not fat—drive chronic diseases, stressing the need for better testing. Listeners will learn to escape the sugar trap, using fasting and sleep optimization to repair metabolic function. The conversation also covers the dangers of seed oils and hidden nutrient deficiencies while offering strategies like potassium balancing and the use of nootropics to enhance metabolic resilience.
109 snips
Jun 24, 2025 • 49min
Why Your Workouts Aren’t Giving You a Summer Body — with Nick Bare : 1294
In this chat, performance-driven entrepreneur and Army veteran Nick Bare shares his insights on why workouts sometimes don’t yield the desired summer body. He emphasizes that consistency is key, not just intensity, and warns against the traps of overtraining. The conversation explores the importance of recovery science, sleep optimization, and the role of mitochondria in energy production. Nick also discusses tackling entrepreneurial stress, balancing ambition with recovery, and leveraging biohacking for enhanced performance and focus.
