The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
72 snips
Aug 12, 2025 • 59min
The New Poisons Lurking Around You – Save Your Longevity : 1313
Join environmental health attorney Alan Bell, author of POISONED, as he uncovers the invisible toxins in our homes that harm our health and accelerate aging. He discusses the connection between these chemicals and various health issues, including their impact on metabolism and brain function. Learn about biohacking techniques like detox protocols and how they can protect your longevity. Alan emphasizes the importance of creating safe environments and shares actionable strategies to improve well-being. Discover how hidden dangers affect everyday life and what you can do to fight back.
147 snips
Aug 8, 2025 • 60min
Jim Kwik: What I Take to Biohack Brain Speed and Focus : 1312
Jim Kwik, a world-renowned brain coach and bestselling author of *Limitless*, shares his journey from a traumatic brain injury to becoming a cognitive enhancement expert. He reveals powerful biohacking techniques, including nootropics and personalized nutrition for brain optimization. Topics like the impact of metabolism on brain speed, neuroplasticity through cold therapy and fasting, and the insights of the 'Brain Animal' system for effective learning are also discussed. Jim's unique approach showcases how adversity can lead to remarkable cognitive growth.
81 snips
Aug 7, 2025 • 1h 39min
Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking) : 1311
Jay Campbell, a leading expert in testosterone optimization and author, joins Hunter Williams, a high-performance coach focused on men’s health. They discuss the surprising benefits of estradiol injections for brain performance and the revolutionary role of peptides like BPC-157 in health optimization. The duo also explores how oral bioregulators can enhance gut-brain signaling and the intricacies of hormone management for longevity. Expect insights on muscle-preserving strategies and the futuristic impact of nootropics on overall wellness!
205 snips
Aug 5, 2025 • 1h 4min
Top 5 Dopamine Boosting Biohacks for Superhuman Energy : 1310
Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health, dives into the world of dopamine and biohacking. He reveals potent compounds like bromantane and ITPP that enhance brain function and energy. Lucas explains how to optimize dopamine for increased motivation and confidence while addressing the intricate relationship between dopamine, testosterone, and masculinity. Listeners learn about the importance of mitochondrial function, hydration strategies, and the pitfalls of common supplements, all aimed at achieving superhuman performance.
102 snips
Aug 1, 2025 • 47min
Protein vs. Plants: The 50g-a-Meal Biohacking Rule : 1309
Join Dr. Gabrielle Lyon, a leader in Muscle-Centric Medicine and nutrition expert, as she shares her insights on the power of protein for longevity and muscle health. She explains why consuming 50 grams of protein per meal is crucial for metabolism and aging. The discussion highlights the importance of leucine and contrasts the benefits of animal versus plant proteins. Dr. Lyon also tackles the pitfalls of plant-based diets for the aging population and emphasizes personalized nutrition strategies to enhance healthspan and performance.
60 snips
Jul 31, 2025 • 54min
The Air Force Uses This Mind-Bending Sound Biohack — Try It Yourself! : 1308
Rev. Michael Beckwith, a leading voice in spiritual transformation, teams up with Henry Penix, founder of SOAAK Technologies, to explore the power of sound frequencies. They discuss how the Air Force uses sound tech for cognitive performance and mental recovery. Discover how frequency healing can rewire brainwaves, reduce anxiety, and optimize sleep. The duo reveals the link between sound and emotional healing, emphasizing the transformative effects of auditory stimulation on overall well-being and personal growth.
146 snips
Jul 29, 2025 • 59min
How To change ANY Habit In 63 Seconds (No Willpower Needed) : 1307
In this engaging dialogue, cognitive neuroscientist Caroline Leaf shares her groundbreaking insights on rewiring habits in just 63 seconds. She debunks the popular 21-day myth of habit formation, revealing that true change takes 63 days of mindful practice. The discussion dives into the mind-brain connection, highlighting techniques for stopping toxic thoughts and enhancing emotional regulation. Dr. Leaf also emphasizes the profound impact of forgiveness on mental health, offering listeners powerful tools for achieving lasting personal transformation.
40 snips
Jul 25, 2025 • 59min
Who Should Take Herbal Ecstasy Supplements? (The Billion-Dollar Backstory) : 1306
Shaahin Cheyene, a renegade entrepreneur, built a billion-dollar supplement empire with Herbal Ecstasy while still a teenager. He shares the wild story of how he transformed natural compounds into high-performance nootropics. The conversation dives into the implications of ephedra's ban, his clashes with the FDA, and the politics of wellness innovations. Cheyene's journey from a tumultuous youth in Iran to a successful Amazon marketer highlights the challenges of the herbal supplement industry and the power of brain optimization.
164 snips
Jul 24, 2025 • 1h 11min
Boost Brain Power by 25% WITHOUT a Pill (Brain Optimization Secrets) : 1305
In a captivating conversation, global finance expert Richard Conrad unveils how cultural programming impacts brain function and performance. He reveals techniques to enhance cognitive capacity by 25% without drugs, emphasizing the importance of thinking beyond linear logic. The discussion dives into how different cultures perceive truth and time, influencing everything from meditation practices to decision-making. Conrad also explores the balance between personal fulfillment and societal roles, making connections between ancient wisdom and modern health practices.
93 snips
Jul 22, 2025 • 54min
The Biohacking Tool That Will Change the World (Mitochondrial Transfusions) : 1304
In this enlightening discussion, Tom Benson, an inventor and founder of Mitrix, unveils cutting-edge concepts around mitochondrial transfusions that could revolutionize longevity and health. He explains how enhancing mitochondrial function might reverse biological aging and supercharge metabolism. The conversation dives into the critical role of mitochondria in cognitive health, their potential to combat neurodegenerative diseases, and the exciting future of personalized mitochondrial therapies. Tune in to explore this groundbreaking frontier in health innovation!
