The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
80 snips
Sep 4, 2025 • 1h 3min
Sulforaphane, Curcumin, and NEW GLP-1 Drugs (Biohacking for Longevity) : 1323
David Roberts and John Gildea, both Johns Hopkins-trained researchers, delve deep into the benefits of sulforaphane and its potential to enhance detox pathways and metabolism, revealing the surprising downsides of regular broccoli. They discuss how targeted supplements like curcumin and berberine can outperform traditional diets and weight-loss drugs. The conversation also includes how biohacking strategies—from fasting to nootropics—can boost brain health and performance, highlighting innovative ways to maximize nutrition without pharmaceutical side effects.
173 snips
Sep 2, 2025 • 1h 29min
Mast Cells Explained: Biohacking Inflammation, Allergies, and Brain Fog : 1322
Dr. Tania Dempsey, a functional medicine physician and co-founder of the AIM Center for Personalized Medicine, dives deep into Mast Cell Activation Syndrome (MCAS) with the host. They explore how dysregulated mast cells may cause unexplained symptoms like allergies and brain fog. Key topics include the interplay between mast cells and mitochondria, the genetic complexities of MCAS, and how environmental factors like mold contribute to chronic illness. Practical biohacking strategies are discussed, highlighting dietary shifts, hormonal balance, and managing stress to optimize health.
131 snips
Aug 29, 2025 • 1h 10min
What Is Uric Acid and How Does It Predict Your Longevity : 1321
David Perlmutter, a leading functional medicine neurologist and bestselling author, discusses the often-overlooked significance of uric acid as a crucial health marker. He reveals how uric acid influences metabolism, brain function, and longevity, and explains lifestyle factors that can spike its levels. Perlmutter also highlights innovative approaches from Japan in tracking this biomarker and emphasizes the role of diet and supplements in managing uric acid. Listeners will gain insights into optimizing their health and vitality through mindful lifestyle choices.
140 snips
Aug 28, 2025 • 1h 15min
Hacking Dopamine Naturally: Pain, Focus, and Performance : 1320
Dr. Anna Lembke, a Stanford psychiatrist and bestselling author of 'Dopamine Nation', dives into the fascinating world of dopamine and its impact on our lives. She explains how pain can actually help reset our reward systems and why our dopamine levels are crucial for motivation and mood. The discussion covers the dangers of overstimulation from modern technology and food, the benefits of cold therapy, fasting, and the societal implications of digital addiction. Lembke also highlights innovative methods like 'dopamine repair parties' to foster resilience and community.
121 snips
Aug 26, 2025 • 1h 47min
You Have A 25% Chance to Lose All Your Memory (Longevity Secrets) : 1319
Join Dr. Dale Bredesen, a world-renowned neurologist and Alzheimer's researcher, as he discusses groundbreaking strategies to prevent and even reverse cognitive decline. Discover how inflammation, toxins, and mitochondrial dysfunction contribute to Alzheimer’s. Dr. Bredesen reveals innovative biohacking techniques like fasting, supplements, and lifestyle changes to optimize brain health. He highlights the pharmaceutical industry's resistance to these solutions and shares actionable tips for young people to future-proof their brains, transforming our understanding of cognitive longevity.
91 snips
Aug 22, 2025 • 54min
The Hormone War Dividing Female and Male Longevity : 1318
Teal Swan, a bestselling author and international speaker, explores the complex relationship between hormones and longevity. She reveals how male and female biology diverges, impacting metabolism and brain function. The conversation dives into the effects of birth control on testosterone and how trauma shapes our biology. Listeners learn about biohacking strategies like fasting, sleep optimization, and supplements to balance hormones for better resilience. Teal's insights bridge psychology and biology, offering profound perspectives on personal transformation.
79 snips
Aug 21, 2025 • 1h 7min
The 10-Second At-Home Walk Test for Longevity (Easy Biohack) : 1317
In a fascinating discussion with Dr. Vonda Wright, a double board-certified orthopedic surgeon and sports medicine pioneer, listeners discover how walking speed can predict longevity more accurately than cholesterol. Dr. Wright shares simple at-home tests for biological age and the importance of pelvic floor health, especially after C-sections. She highlights the pivotal role of hormones during perimenopause and offers biohacking tips to boost metabolism and vitality. With insights on strength training and brain health, this talk encourages a proactive approach to aging gracefully.
125 snips
Aug 19, 2025 • 1h 8min
PhD at MIT: The Longevity Molecule That Reverses Aging (250 Studies) : 1316
Dr. Leonard Guarente, an MIT PhD and a leading authority on longevity, shares groundbreaking insights on aging. He explains how NAD+ is crucial for mitochondrial health and how sirtuins can enhance resilience and recovery. They discuss DNA methylation as a measure of biological age and delve into innovative dietary strategies for longevity. With insights on supplements, fasting, and the intriguing relationship between homocysteine and brain health, this conversation is a treasure trove of tips to optimize your longevity journey!
162 snips
Aug 15, 2025 • 60min
Still Fasting in 2025? Here’s How to Make It Work Better : 1315
In this conversation, Christian Drapeau, a leading stem cell scientist and founder of STEMREGEN, unveils groundbreaking techniques for activating stem cells to enhance recovery and performance. He discusses how fasting boosts stem cell effectiveness, the importance of microcirculation, and the synergy of various biohacking tools like PEMF and cold therapy. Drapeau shares practical strategies for nutrition and supplements that drive mitochondrial health and longevity, while addressing how stem cells can revolutionize recovery from injuries, particularly in athletes.
103 snips
Aug 14, 2025 • 52min
How to Make Life-Changing Decisions Without Fear – Joe Hudson : 1314
In this discussion with Joe Hudson, a world-renowned executive coach, listeners explore how unresolved emotions hinder decision-making and peak brain performance. Joe shares insights on reprogramming the nervous system and nurturing emotional intelligence for clear, resilient thinking. He delves into somatic awareness and emotional release techniques that enhance energy, focus, and relationships. The conversation emphasizes embracing fear and vulnerability as pathways to authenticity and profound personal transformation in both professional and personal realms.
