The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
Dec 9, 2021 • 1h 18min
Hacking Longevity Starts with Detoxification – Chris Shade, Ph.D. : 884
Chris Shade, Ph.D., founder of Quicksilver Scientific, discusses detoxification's crucial role in longevity. He introduces a six-spoke 'longevity wheel' to illustrate how toxins and hormones impact aging. The conversation dives into the effectiveness of methods like coffee enemas and bile flow in liver health. Shade outlines a structured three-month detox plan aimed at enhancing cellular health and resilience. He also explores alternatives to hormone replacement for women and the significance of monitoring hormones to optimize well-being.
Dec 7, 2021 • 1h 17min
Toss the Candles! Biological Age Is Your New Birthday – Ryan Smith : 883
Ryan Smith, co-founder of TruDiagnostic and a biochemist, dives into the fascinating world of biological aging. He reveals how epigenetic methylation can determine your biological age compared to your chronological age. The discussion underscores the importance of understanding this distinction for health and longevity. They explore innovative blood tests for anti-aging insights, the role of machine learning in assessing biological age, and even the impacts of environmental factors like lead. Get ready to rethink your approach to aging!
Nov 30, 2021 • 54min
A Bacteria That Guards Your Gut Lining – Colleen Cutcliffe, Ph.D. : 881
Colleen Cutcliffe, Ph.D., founder of Pendulum Therapeutics, dives into the fascinating world of gut health. She explains how the gut lining acts as a protective barrier and introduces Akkermansia, a bacteria that enhances gut integrity and immune response. The conversation covers how dietary practices, like fasting and fiber intake, influence gut microbiome health. They also discuss the interplay between probiotics and prebiotics and reveal innovative research linking gut health to conditions like diabetes, making a strong case for prioritizing gut wellness.
Nov 26, 2021 • 12min
Mini-Episode: Cool Facts Friday #17
Discover how migraines can disrupt your deep and REM sleep, impacting overall well-being. Explore the fascinating ways your gut microbiome influences Type 2 diabetes, and learn about innovative biodegradable materials for male contraception. Uncover how specialized video games are helping kids manage their emotions effectively. Finally, challenge traditional sleep norms as studies reveal that around 6.5 hours of quality sleep may actually benefit your brain health.
Nov 23, 2021 • 35min
Alzheimer’s Targets Women’s Brains Decades Before Symptoms Show – Maria Shriver & Dr. Lisa Mosconi : 880
Maria Shriver, an award-winning journalist and advocate for Alzheimer’s awareness, joins Dr. Lisa Mosconi, a neuroscientist specializing in brain health. They delve into why Alzheimer’s disproportionately affects women, often revealing symptoms decades earlier than presumed. The duo discusses the critical links between hormonal changes, stress, and nutrition in preventing cognitive decline. They also emphasize innovative community efforts and proactive steps like mental stimulation and exercise for enhancing brain health, shedding light on essential strategies for awareness and prevention.
Nov 19, 2021 • 1h 6min
Temperature Hacking for Better Deep and REM Sleep – Matteo Franceschetti : 879
Matteo Franceschetti, co-founder of Eight Sleep and former professional athlete, shares his insights on achieving optimal sleep quality. He emphasizes the importance of sleep as a health pillar and discusses innovative technology that adapts to your sleep environment. Dive into the benefits of sleep temperature regulation, the impact of diet and alcohol on sleep quality, and how personalized data can revolutionize your rest. Matteo's experiences illustrate the journey from struggling with sleep to pioneering cutting-edge solutions for better nights.
Nov 17, 2021 • 1h 24min
How to Deal with Toxic People (Including Yourself) – Robert Greene : 878
Robert Greene, a New York Times bestselling author known for his gripping insights on power and human behavior, dives into how to navigate toxic relationships, including the toxic behaviors we may unknowingly exhibit ourselves. He provides actionable strategies for self-awareness, emphasizing the importance of reflection in personal growth. Greene also humorously shares his unexpected rise to TikTok fame and discusses the complexities of envy, making this a compelling conversation for anyone looking to enhance their personal power and self-understanding.
Nov 13, 2021 • 1h 3min
How Postbiotics Upgrade Your Mitochondria – Dr. Anurag Singh : 877
Dr. Anurag Singh, Chief Medical Officer of Amazentis and expert in clinical development, dives into the fascinating world of Urolithin A and its powerful benefits for mitochondrial health. He discusses how this compound stimulates mitophagy, refreshing our cellular energy systems, and explores its anti-aging properties. The conversation also touches on the intriguing origins of Urolithin A linked to beavers and emphasizes practical tips for maximizing mitochondrial function with supplements like MitoPure.
17 snips
Nov 12, 2021 • 1h 19min
The Best and Worst Foods for Your Metabolic System – Dr. Casey Means : 876
Dr. Casey Means, co-founder and chief medical officer of Levels Health, discusses her journey from surgery to metabolic health, emphasizing prevention over treatment. She reveals alarming statistics—88% of Americans have poor metabolic markers—and stresses the importance of food choice, highlighting how breakfast options affect glucose levels. Discover the health benefits of cinnamon and the misconception that all calories are equal. Means also explores the link between blood sugar, mood, and overall well-being, advocating for a data-driven approach to personal health.
Nov 10, 2021 • 1h 10min
Mattress Smarts 101 for High-Performance Sleep – Jack Dell’Accio : 875
Jack Dell’Accio, CEO of Essentia Mattresses, shares his 16 years of expertise in creating high-performance, toxin-free mattresses. He discusses how mattress design can enhance sleep quality and athletic recovery. The conversation covers the differences between natural and synthetic latex, the importance of personalized sleep environments, and innovative EMF protection strategies in mattresses. Dell’Accio emphasizes making informed choices for a healthier sleep experience, ultimately connecting mattress quality to overall well-being and performance.
