The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
Jun 15, 2022 • 1h 5min
How to Build a Better Brain, Brand & Business – Patrick Schwarzenegger : 947
Patrick Schwarzenegger, an actor, investor, and brain health advocate, shares insights from his entrepreneurial journey, including his venture MOSH, co-founded with his mother, Maria Shriver, focused on brain health. He discusses balancing activism and business while promoting healthier lifestyle choices. Patrick reflects on his early investments, like Blaze Pizza, and emphasizes the importance of innovation in the food industry. He also addresses the challenges of transitioning from e-commerce to retail and the need for wellness in both personal relationships and professional environments.
Jun 10, 2022 • 32min
Mushroom Upgrade: Big Benefits for Human Biomes and Natural Ecosystems – Paul Stamets & Julian Mitchell : 946
In this conversation, mycologist Paul Stamets, a warrior of fungal research, and Julian Mitchell, CEO of Life Cykel, explore the profound connections between humans and mushrooms. They discuss how fungi benefit cellular health, boost immune systems, and enhance neurogenesis. The duo shares fascinating insights on the future of food, highlighting the nutritional power of mushrooms like lion's mane and oyster. They also delve into innovative uses of mycelium for environmental improvement and bee health, showcasing mushrooms as key players in sustainability.
16 snips
Jun 8, 2022 • 29min
Breathing Upgrade: Get It Right & Catch Some Serious Air – Patrick McKeown & James Nestor : 945
In this enlightening discussion, breathing experts Patrick McKeown, an acclaimed author known for his deep research on breathing, and James Nestor, a noted journalist and author on the science of breath, unravel how our breathing affects all aspects of health. They emphasize the enormous benefits of nasal breathing over mouth breathing, citing its impact on everything from sleep and athletic performance to mental focus. Dive into groundbreaking research covering the biochemical and psychological effects of proper breathing, revealing how small changes can lead to profound health improvements.
4 snips
Jun 4, 2022 • 30min
Upgrade Spotlight: How a Peptide Gets Under Your Skin to Combat Aging – OneSkin : 944
Carolina Reis Oliveira, CEO and co-founder of OneSkin, brings her impressive background in immunology and biochemistry to discuss innovative solutions for skin rejuvenation. She reveals how their proprietary peptide OS-01 targets aging at the molecular level, combating the effects of senescent 'zombie cells' and even reversing biological skin age. The conversation also dives into the importance of clean beauty standards and how these groundbreaking products serve as daily topical supplements for resilient skin. Get ready to rethink your skincare routine!
Jun 3, 2022 • 58min
How to Manage Sugar for a Better Brain and a Longer Life – Colleen Cutcliffe, Ph.D. : 943
Colleen Cutcliffe, Ph.D., is the CEO and co-founder of Pendulum Therapeutics, focusing on microbiome-based products for metabolic health. In this conversation, she unveils groundbreaking insights into how sugar impacts the gut microbiome and cognitive function. Cutcliffe discusses the significant reduction in glucose spikes achieved by their innovative probiotics. She also emphasizes the critical link between diet, physical activity, and gut health, while exploring future innovations in bacterial engineering to enhance overall wellness.
Jun 1, 2022 • 1h 7min
How 5 Self-Coaching Steps Get You to Your Goals – Jason Goldsmith : 942
Jason Goldsmith, a performance coach who has guided both athletes and Fortune 500 executives, discusses empowering self-coaching methods. He emphasizes the importance of blending mental and physical aspects of performance to unlock personal success. Goldsmith explains how joy impacts productivity and how self-awareness can help identify joy blockers. He introduces innovative strategies for mastering personal development and achieving goals, advocating for a structured approach over sheer willpower while sharing insights on effective communication and community support.
May 27, 2022 • 17min
Mini-Episode: Cool Facts Friday #23
Discover surprising facts that could change your health journey! Learn about the effectiveness of vitamin D in cutting cancer risk and the amazing potential of sauna therapy to reverse neurological issues. Uncover the role of active brown fat in metabolism and its connection to pre-diabetes. Plus, dive into the latest insights on making stem cells younger and the science behind brain communication. Get ready for a burst of fascinating health innovations!
6 snips
May 27, 2022 • 1h 6min
How to Slow Down Your Biological Aging – Morgan Levine, Ph.D. : 941
Morgan Levine, Ph.D., an expert in biological aging and director at Yale University’s Laboratory for Aging in Living Systems, discusses groundbreaking insights into aging. She emphasizes that biological age is a greater risk factor for diseases like Alzheimer’s than chronological age. The conversation delves into innovative approaches to measure biological age and the quest for reversing aging processes. Levine also highlights personalized ageotypes and the role of lifestyle choices in extending healthspan, merging science with the potential for improved longevity.
4 snips
May 24, 2022 • 1h 16min
How Focus and Attention Powers Your Mind – Amishi Jha, Ph.D. : 940
In a captivating discussion, Amishi Jha, Ph.D., a neuroscientist and psychology professor at the University of Miami, explores the dual nature of attention as our superpower and kryptonite. With over 25 years of research experience, she highlights how fractured attention affects mental health and cognitive function. Jha shares insights on mindfulness techniques that enhance working memory and decision-making, emphasizing the importance of focus in a distracted world. Discover how personalized mindfulness practices can transform your attention and overall well-being!
5 snips
May 21, 2022 • 48min
Hacking Your Biohacks for Better Sleep, Fitness & Weight Control – Interventions With Dave – Sean Plotkin : 939
Sean Plotkin, a biohacker in his mid-40s, dives into how he's enhancing energy, strength, and weight management. Discussing his intense exercise routine, he reveals concerns about thyroid function and nutrition. The conversation covers the importance of sleep quality, nutrient availability, and stress management. Sean shares his experiences with various biohacking tools like continuous glucose monitors and hyperbaric chambers. They also touch on the interplay of hormones, inflammation, and metabolic health, offering insights for achieving peak performance.
