The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
37 snips
Oct 28, 2025 • 43min
Biohacking Cannabis: The DNA Science of Plant Medicine : 1353
Len May, CEO of EndoDNA and a leader in genomics and medicinal cannabis, talks about revolutionizing health through personalized DNA insights. He reveals how genetics can determine your response to cannabis and psychedelics, enhancing mental health and performance. Throughout the discussion, Len emphasizes the importance of tailored formulations, the role of the endocannabinoid system, and using genetic data to avoid adverse reactions. With compelling anecdotes, he highlights how personalized cannabis strategies can dramatically improve life quality and well-being.
137 snips
Oct 26, 2025 • 18min
This Legal Focus Powder Beats Any Dopamine Detox : 1352
Discover how low brain energy can hinder focus and motivation, instead of just blaming dopamine. Learn about the crucial role of ATP in brain function and how stress and diet might damage your mitochondria. Explore biohacks to boost your energy production, including the surprising benefits of creatine as a powerful nootropic. This affordable supplement can enhance memory and resilience against stress, especially for vegans and those under pressure. Get tips on optimal dosing and hydration to maximize your brain's performance!
73 snips
Oct 24, 2025 • 6min
Biohacking News Weekly Update : 1351
In this gripping update, discover how 2,000 IU of vitamin D is becoming a game-changer in slowing telomere shortening and promoting biological youth. Uncover the secrets of the supercentenarian gene that reverses cardiac aging, potentially leading to superhuman longevity. The FDA shakes up the supplement world by closing the GRAS loophole, ensuring more accountability. Plus, learn how certain gut bacteria can trigger autophagy and explore the exciting future of health with digital twins and AI-driven health predictions.
143 snips
Oct 23, 2025 • 34min
How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350
In this deep dive into nicotine, discover its surprising benefits as a nootropic. Learn how to optimize brain performance with low-dose nicotine while minimizing addiction risks. The discussion covers the importance of timing, stacking it with other supplements, and cycling to avoid tolerance. Delve into its potential in neuroprotection and implications for conditions like Alzheimer’s. Plus, hear practical tips on using patches and microdosing to enhance mental clarity and support overall health.
72 snips
Oct 21, 2025 • 57min
Why Women’s Joints Are Failing 10x Faster : 1349
Kiran Krishnan, a seasoned research microbiologist and Chief Scientific Officer at Calroy Health Sciences, shares his insights on the critical factors behind joint health decline. He reveals how systemic inflammation and mitochondrial dysfunction contribute to cartilage loss, highlighting that joint pain is often mishandled by conventional treatments. Krishnan discusses innovative solutions, including Cartigenix HP, which utilizes unique boswellia actives and celery seed extracts to combat inflammation. Furthermore, he emphasizes the importance of hormonal changes in midlife women, advocating for proactive measures to maintain joint health.
120 snips
Oct 19, 2025 • 13min
Why You Still Feel Tired And Foggy On A Perfect Diet : 1348
Explore the hidden disruptors that may be affecting your energy and focus, even with a perfect diet. From the impact of EMFs on sleep quality to the dangers of mold in your home, learn why it's crucial to consider your environment. Discover detox hacks to flush out toxins, rebuild essential nutrients, and unleash your mitochondrial power. Plus, practical tips for resetting your circadian rhythm and enhancing digestion, including the benefits of box breathing and gratitude in your daily routine.
75 snips
Oct 17, 2025 • 6min
10 Minute Weekly Biohacking Update : 1347
Explore the future of health as new longevity scores from Elegant Hoopoe track biological aging, with users reporting impressive improvements. Discover how AI is revolutionizing heart diagnostics by speeding up echocardiograms. Learn about the promising results of brain training that rejuvenates neurotransmitters after just ten weeks. Dive into innovations presented at HLTH 2025, featuring digital twins and real-time wearables for hormone and immunity tracking. Plus, find out how single-vial blood tests can streamline health screenings.
110 snips
Oct 16, 2025 • 57min
These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks) : 1346
Alberto Villoldo, Ph.D., a medical anthropologist and founder of The Four Winds Society, dives into the intersection of ancient healing and modern neuroscience. He discusses how sacred plants activate over 1,100 healing genes to promote brain growth and longevity. Alberto reveals insights on neurogenesis, the transformative powers of psychedelics, and the profound role of mindset in healing. He also emphasizes personal health responsibility and integrating plant wisdom with diet and emotional resilience for optimal well-being.
97 snips
Oct 14, 2025 • 27min
Solo Episode - Nicotine Masterclass (pt. 1) : 1345
Nicotine is often misunderstood, but low-dose use might enhance brain performance and longevity. Controlled intake could improve focus, memory, and neuroplasticity while separating its benefits from the dangers of smoking. The podcast dives into nicotine's mechanisms, exploring how it affects neurotransmitters and metabolic health. Learn about the best delivery methods and why some forms are safer than others. It also addresses potential risks, including dependency and cardiovascular effects, setting the stage for a deeper exploration of this controversial compound.
74 snips
Oct 13, 2025 • 16min
7 Toxic Foods POISONING Your Family's Health (Avoid These!) : 1344
Explore the hidden dangers of common toxic foods that many unknowingly consume daily. Discover how cheap processed seed oils infiltrated our diets and the alarming effects on health, from inflammation to accelerated aging. Uncover the unsettling history behind these oils and their detrimental impact on brain function and vitality. Learn practical tips on healthier cooking options and how to reclaim your health from the food industry’s misleading marketing. This is essential listening for anyone invested in their well-being!
