The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
46 snips
Dec 28, 2025 • 13min
I Lost 100 Pounds By Fasting Like THIS (The Missing Step) : 1387
Discover the hidden fasting mistakes that can lead to muscle loss instead of fat loss. Learn how to flip the body's fat-burning switch for effective weight management. Explore the importance of muscle mass as a key to longevity and how poor habits can sabotage your progress. Get insights on breaking a fast correctly to maximize benefits. Dave shares practical tips from his own journey of losing 100 pounds, emphasizing the balance of diet, exercise, and mindset for optimal results.
63 snips
Dec 26, 2025 • 12min
Biohacking News Weekly Update : 1388
Trump's new drug pricing agreements could lower out-of-pocket costs for essential medications, impacting access to longevity treatments. A study reveals that 5:2 intermittent fasting outperforms daily dieting in improving metabolic health. Discover how aligning low-calorie days with recovery can enhance fasting results. Fascinating research links theobromine in cocoa to slower aging, while organ-specific aging clocks offer better disease prediction. Plus, learn how copper peptides can boost skin repair and actionable tips to enhance your health journey.
9 snips
Dec 25, 2025 • 1h 13min
How to Get and Stay Sober in 2026 (The Biohacker’s Guide) | Luke Storey : 1386
Luke Storey, a motivational speaker and host of The Life Stylist, shares his journey through addiction recovery and spiritual awakening. He emphasizes that sobriety isn't just about willpower, discussing how addiction can manifest in various forms, including socially accepted behaviors. Their conversation probes the impact of community and trauma on recovery, explores the role of psychedelics and spirituality, and highlights practical biohacks that support long-term healing. Storey also provides insights on discerning intuition from cravings and the importance of integration in recovery.
66 snips
Dec 23, 2025 • 1h 3min
What it takes to be “Young Forever!” | Mark Hyman : 1385
Mark Hyman, a leading physician in functional medicine and author of *Young Forever*, joins to discuss the biology of aging. He explains how insulin signaling, mTOR, and mitochondrial health play crucial roles in reversing biological age. Mark reveals that sugar can accelerate aging more than protein and debunks myths surrounding protein and carnivore diets. With real-life examples of patients reversing diseases through lifestyle changes, he emphasizes the importance of metabolic flexibility and treating root causes for optimal health.
59 snips
Dec 21, 2025 • 13min
I Tried $50 Brain Boosting Powder : 1384
Discover why cognitive decline and muscle loss can start in your 30s, driven by ATP production rather than age. Learn about the connection between muscle health and brain function, and how damaged mitochondria can accelerate aging. Dave reveals creatine as a cost-effective supplement for boosting brain energy and memory, sharing tips on effective usage and dosage. He also discusses the importance of proper timing and hydration to maximize benefits. Tune in for actionable insights on enhancing mental sharpness and physical resilience!
45 snips
Dec 19, 2025 • 11min
Biohacking News Weekly Update : 1383
The FDA is considering changing supplement warning labels, which could blur the line between marketing and medical claims. A new heart-monitoring device from Mayo Clinic promises earlier detection of heart issues using quantum sensors. Sweating in saunas has been shown to effectively detoxify microplastics from the body. Meanwhile, an experiment with psychedelics revealed surprising benefits for glucose control. Plus, research on mitochondrial proteins hints at new ways to extend lifespan.
44 snips
Dec 18, 2025 • 58min
The Science of Erotic Altered States | Biohacking Sex : 1382
Kimi Inch, a somatic therapist and educator renowned for her work at the crossroads of intimacy and trauma healing, discusses the transformative power of erotic play. She reveals how practices like breath and impact play can trigger healing neurochemical responses, connecting sexuality to personal development. Kimi emphasizes the importance of maturity and consent in erotic experiences, while exploring the balance of surrender and connection. Their conversation highlights fantasy as a key to understanding unmet needs and integrating sexuality into one’s overall well-being.
13 snips
Dec 16, 2025 • 1h 4min
Biohacking Fertility for Men and Women at Any Age : 1381
Dr. Ann Shippy, a board-certified physician and functional medicine expert, shares insights into optimizing fertility for future parents. She connects rising infertility rates with childhood health issues, emphasizing the impact of environmental toxins. Dr. Shippy highlights the importance of preconception health as a key to a child's development and explains that men play an equal role in fertility health. Nutrition, lifestyle changes, and addressing chronic issues can significantly improve outcomes, making preparation essential for prospective parents.
67 snips
Dec 14, 2025 • 16min
Your Brain Has A Sleep Switch (Do THIS To Turn It On) : 1380
Discover the brain's hidden switch that controls deep sleep and how it's often turned off. Learn about the surprising impacts of posture and meal timing on your sleep quality. Find out how gravity contributes to restless nights and the corrections you can make for better rest. Dive into the crucial 3-hour rule for food, and understand how light exposure affects melatonin production. With practical tips like using TrueDark glasses and optimizing your bedroom environment, you'll be equipped to enhance your sleep and wake up revitalized!
59 snips
Dec 12, 2025 • 52min
The One Thing Everyone Thinks They Can’t Afford… Until They Try It : 1379
In a captivating discussion, Jonathan Swanson, founder of Thumbtack and Athena, reveals the transformative power of delegation. He shares how offloading mundane tasks can enhance cognitive function, reduce stress, and improve sleep quality. Swanson emphasizes the emotional benefits assistants provide, becoming trusted allies in both work and personal life. The conversation covers practical strategies for leveraging executive assistants to reclaim time and focus on higher-value goals, highlighting the future potential of combining human skill with AI.
