This episode covers:
• FDA Loosening Supplement Warning Labels
The FDA is considering a rule change that would allow supplement companies to include the DSHEA disclaimer only once per package rather than next to every claim. Dave explains why fewer visible warnings could make marketing look more like medical claims, and why biohackers should treat labels as advertising rather than evidence. He shares how to protect yourself now: add one variable at a time, run baseline labs, and rely on data instead of packaging.
Source: https://www.nbcnews.com/health/health-news/fda-supplements-warning-label-rule-change-rfk-jr-rcna249321
• Quantum Sensors for Early Heart Attack Detection
Mayo Clinic is testing a contactless heart-monitoring system called CardiAQ using quantum magnetic sensors and AI noise filtering. The device reads subtle electromagnetic signatures from the heart and compares them to invasive angiography. Dave breaks down why earlier detection of ischemia could shift heart care from reactive treatment to proactive screening — and why building baseline metrics like VO₂max, blood pressure and HRV today will pay off when next-gen diagnostics arrive.
Source: https://www.sandboxaq.com/press/sandboxaq-collaborates-with-mayo-clinic-on-novel-cardiac-diagnostics
• Sauna Detox for Microplastics
Emerging research shows that sweating meaningfully removes plastic-related chemicals like BPA and phthalate metabolites from the body, often more efficiently than blood or urine alone. Sauna use amplifies this effect by increasing circulation, mobilizing stored toxins from tissues, and accelerating sweat-based excretion. When you combine regular heat exposure with reduced environmental plastic contact, you create a powerful detox strategy that targets a chemical burden once thought unavoidable. Dave breaks down how sauna protocols can support toxin elimination, improve cardiovascular resilience, strengthen autonomic balance, and help counteract the metabolic and hormonal disruptions linked to microplastics in modern life.
Source: https://superage.com/can-you-sweat-out-microplastics-in-the-sauna/
• Psychedelics and Longevity Biomarkers
Bryan Johnson treated a guided psilocybin experience as a structured longevity experiment, collecting nearly 250 biomarkers including CGM, stress markers, HRV and Kernel brain imaging. The experiment revealed a surprising metabolic change: mean glucose dropped 8 percent, variability fell 11 percent, and estimated HbA1c moved from 4.7 to 4.4 — similar to months of metformin but after a single session. Dave explores the emerging idea that neuroplastic events might influence glucose regulation through brain-pancreas signaling, while emphasizing the need for supervised, legal use and proper clinical trials.
Source: https://www.businessinsider.com/bryan-johnson-trip-on-mushrooms-five-hours-live-2025-12
• A Mitochondrial Protein that Extends Mouse Lifespan
Researchers boosted the mitochondrial protein COX7RP and extended mouse lifespan by ~6.6 percent while improving insulin sensitivity, lipid handling, endurance and liver fat metabolism. COX7RP supports formation of mitochondrial “supercomplexes,” improving respiratory efficiency and ATP generation. Dave explains how this reinforces lifestyle levers — strength training, aerobic capacity, stabilizing blood sugar — as tools that likely preserve supercomplex architecture and mitochondrial resilience.
Source: https://www.eurekalert.org/news-releases/1109082
All source links provided for direct access to the original research and reporting.
This episode is designed for biohackers, longevity seekers and high-performance listeners who want practical strategies rooted in cutting-edge science. Dave Asprey translates emerging research into actionable upgrades for your biology — from metabolism and mitochondria to nervous system health, detox, and prevention.
New episodes every Tuesday, Thursday, Friday, and Sunday.
Keywords: FDA supplement rule change, supplement warning labels, DSHEA disclaimer removal, supplement regulation risks, quantum cardiac scanner, Mayo Clinic heart attack detection, AI heart monitoring, early ischemia detection technology, sauna detox evidence, sweating out toxins research, BPA phthalate sweat studies, microplastics sauna myth, Bryan Johnson psilocybin experiment, psychedelic longevity research, psychedelic metabolic reset, glucose control psychedelics, HbA1c psilocybin results, continuous glucose monitor insights, mitochondria lifespan research, COX7RP protein aging study, mitochondrial supercomplex benefits, ATP energy output aging, metabolic flexibility longevity, biohacking news update, anti-aging science breakthroughs, evidence-based longevity tools, biological age biomarkers
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Timestamps:
0:00 - Intro
0:18 - Story 1: FDA Supplement Label Changes
1:43 - Story 2: CardiAQ Heart Scanner
2:59 - Story 3: Saunas and Microplastics
4:58 - Story 4: Psychedelics and Blood Sugar
8:22 - Story 5: Mitochondrial Longevity Research
10:29 - Weekly Wrap-Up
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The Human Upgrade: Biohacking for Longevity & Performance