The Human Upgrade with Dave Asprey

Daniel Everett, a renowned linguist and explorer, discusses his groundbreaking research with the Pirahã tribe, revealing how their unique language reshapes cognitive processes. He challenges traditional theories by emphasizing that language not only facilitates communication but also influences thought and perception. The conversation dives into the neurological benefits of learning new languages, the potential for AI to truly 'think,' and how our environments and even altered states of consciousness impact language evolution.

Sharon Hausman-Cohen, a Harvard-trained physician and genomics expert, reveals how our DNA isn't our destiny. She discusses the empowering science of genetic optimization, explaining how to activate longevity genes and inhibit disease pathways. The conversation covers the truth about 'bad' genes, such as MTHFR and APOE4, along with personalized strategies to combat brain fog and fatigue. Sharon highlights breakthroughs in DNA biohacking and the future of gene editing for enhanced health, making clear that personalized medicine is the key to unlocking our full potential.

BJ Fogg, a Stanford researcher and author of 'Tiny Habits,' teams up with James Clear, the mastermind behind 'Atomic Habits,' to unravel the secrets of habit formation. They reveal that emotions—not just willpower—play a pivotal role in making habits stick. BJ shares techniques for leveraging joy to drive behavior change, while James emphasizes the power of small, cumulative decisions. Together, they explore the importance of clear cues, celebrating progress, and a compassionate approach to shaping lasting habits.

Discover how to naturally enhance oxytocin for better relationships and reduced stress. Learn tips to optimize your cold plunge routine for significant benefits in less time. Delve into the longevity potential of rapamycin and its effects on brain power and mood. Explore innovative approaches for improving emotional recognition and well-being in individuals with Asperger's. Gain insights into retraining the nervous system and the significance of emotional mastery techniques for personal healing and growth.

Chris Rhodes, a biochemist and longevity researcher, discusses groundbreaking fasting mimetics that could transform health without the need to fast. He explains how Mimeo, a blend of four fasting metabolites, can extend lifespan by 96% while maintaining food intake. The conversation covers optimal fasting windows, the dangers of over-fasting on metabolism and hormones, and why traditional longevity drugs may not be effective. Rhodes highlights the balance between indulgence and health, paving the way for innovative approaches to nutrition.

Dr. Andrew Salzman, a Harvard-trained physician and scientist renowned for creating the first PARP1 inhibitor, reveals the transformative power of NAD in enhancing energy and longevity. He discusses how NAD levels drop with age, leading to fatigue and disease risks. Discover the hidden enzyme CD38 that hampers your health, and learn actionable strategies to boost NAD naturally for better mitochondrial function. Salzman also challenges the conventional supplement industry, advocating for innovative approaches to aging and cellular health.

Dr. Benjamin Bikman, a Ph.D. professor at BYU and author of "How Not To Get Sick," joins the discussion to reveal groundbreaking insights into insulin resistance and its role in obesity and chronic disease. He debunks popular dietary myths, explaining how hormones, rather than just calories, impact metabolism. Discover how dietary fat may reverse metabolic dysfunction and the importance of fasting and light quality for health. Plus, learn why some people maintain a healthy weight despite high carb intake and the hidden connections between insulin and skin health.

Rick Rubin, a legendary music producer known for working with icons like Jay-Z and Johnny Cash, shares his insights into unlocking creativity. He discusses the importance of meditation and mindfulness for artistic breakthroughs. Rubin unveils how biohacking can elevate creative performance and explains the surprising connection between experimentation and artistic flow. He emphasizes creating an environment that nurtures creativity and reveals his personal tools for mental clarity, enabling artists to tap into their full potential.

Tony Robbins, a bestselling author and entrepreneur, shares insights from his decades of coaching billionaires and elite performers. He discusses how a scarcity mindset holds people back and reveals strategies to achieve financial freedom. Fear, he says, is the greatest enemy in personal success. Robbins emphasizes investing in both health and wealth, introducing innovative wellness techniques and groundbreaking advancements in stem cell therapy. He explores the true essence of happiness and fulfillment beyond financial gain, urging listeners to pursue passion and purpose.

Timbaland, the legendary producer behind hits for Jay-Z and Beyoncé, shares his remarkable journey of overcoming addiction and losing 130 pounds. He reveals the powerful mindset shift that enabled his transformation and stresses that self-discipline trumps willpower. Timbaland opens up about the realities of opioid addiction, his clean recovery without rehab, and the importance of daily habits. He also emphasizes the role of vulnerability in healing, urging listeners to embrace their personal stories for growth.