The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
41 snips
Dec 11, 2025 • 48min
How To Sculpt a Perfect Jawline WITHOUT Surgery : 1378
Brandon Harris, founder of Jawzrsize and a former mixed martial artist, dives into the surprising benefits of jaw strength. He shares his journey from a severe jaw injury to developing a jaw resistance device that enhances oral health, cognitive function, and posture. The discussion reveals how targeted jaw training can combat issues like sleep apnea, improve digestion through increased saliva, and even support athletic performance. Brandon's insights challenge conventional views on jaw care, emphasizing its foundational role in overall health.
63 snips
Dec 9, 2025 • 52min
I Tried At-Home Ultrasound for My Brain : 1377
Jon Hacker, a biomedical engineer and CEO of NeurGear, shares insights on how focused ultrasound can help regulate the vagus nerve. He explains the detrimental effects of chronic stress and the sympathetic state many find themselves in. Jon discusses the science behind ultrasound's ability to activate the nervous system, and why traditional electrical stimulation often falls short. He also dives into the effects of trauma, the importance of vagal tone, and how daily use of ZenBud promotes resilience and emotional balance.
103 snips
Dec 7, 2025 • 12min
What If You Stop Eating For 72 Hours? : 1375
What if skipping food for 72 hours could actually reverse aging? Discover how the body traverses critical phases during fasting, triggering cellular repair through autophagy. Learn why short fasts fall short and what common mistakes can sabotage your progress. Dave shares insights on strengthening mitochondria, sharpening the mind, and refeeding safely after fasting. Plus, dive into the importance of listening to your body during this transformative journey.
96 snips
Dec 5, 2025 • 57min
The Real Reason Your Face Is Aging So Fast : 1376
Join Dr. Nayan Patel, a pharmacist and wellness entrepreneur known for his innovative skincare formulations, as he unpacks the science behind aging skin. He explains how nutrients like GHK copper peptides and glutathione can enhance collagen production and improve skin resilience. Discover the importance of delivery systems, including why transdermal methods outperform traditional skincare. Dr. Patel also shares tips on layering serums effectively and highlights the benefits of GHK for hair and skin. Get ready to upgrade your skincare routine!
166 snips
Dec 4, 2025 • 1h 1min
Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374
Ilan Sobel, CEO of BioHarvest Sciences, leads the charge in revolutionary plant-derived supplements. He discusses how their Botanical Synthesis technology creates potent compounds from grape cells without the waste of traditional methods. The conversation touches on VINIA's impressive clinical results, including a 70% increase in arterial dilation and cognitive benefits. They also delve into alternative compounds like verbascoside from olives and future innovations with saffron, making biohacking more accessible and sustainable.
118 snips
Dec 2, 2025 • 56min
The Machine That Flicks on Your Brain in 30 Seconds | Biohacker Tools : 1373
Raffaele Gianfrancesco, a master healer and consciousness technologist, dives into the transformative power of light and vibroacoustics. He reveals how his innovative technology can induce rapid brain state shifts and release stored trauma in minutes, all without years of meditation practice. Raffaele discusses the influence of vibrational frequencies on emotional regulation, the interplay of sound and sacred geometry, and the integration of these tools in therapeutic settings. He also touches on the fascinating relationship between sound, light, and human resilience.
73 snips
Nov 30, 2025 • 23min
How I Lost 100 Pounds By Drinking Butter Coffee : 1371
A health crisis leads to a life-changing sip of yak butter tea in Tibet, sparking a revolution. Discover the origins of Bulletproof Coffee and its cultural impact across Silicon Valley. Break the myth around fats and learn how quality foods can regulate hormones and support fat loss. Explore the perks of intermittent fasting, smart training strategies, and the hidden toxins sabotaging weight loss. A focus on mitochondrial health unveils a path to energy and longevity, culminating in a remarkable 100-pound transformation.
107 snips
Nov 28, 2025 • 45min
Get a Full Body Workout in 10 Minutes by Doing NOTHING | Biohacks : 1372
Dr. Tommy Rhee, a board-certified chiropractor and innovator in sports medicine and regenerative therapy, shares revolutionary insights into body workouts. He explains how standing on a Power Plate can unlock benefits like improved circulation and energy without traditional exercise. Learn how targeted vibration boosts nitric oxide production, enhances microcirculation, and aids in recovery from sitting-related issues. Rhee also highlights its effectiveness for athletes as a warm-up, the calming effects on stress, and the importance of doing less for more health benefits.
53 snips
Nov 27, 2025 • 1h 16min
These Secret Compounds Help Injuries Recover 2-3x Faster : 1370
Dr. Cameron Chestnut, a board-certified facial plastic surgeon specializing in advanced techniques for high performers, joins the discussion on innovative approaches to surgery and recovery. He shares strategies for preparing for surgery like an athlete, emphasizing sleep and nutrition. The conversation explores brain-friendly anesthesia options to prevent post-operative brain fog and the benefits of ketones for neuronal resilience. Cameron also highlights the importance of tailored IV therapies and dietary choices for speeding up recovery and enhancing healing.
69 snips
Nov 25, 2025 • 51min
Why Breathwork Feels Like a Euphoric Drug | Biohacker Tips : 1369
Ishan Shivanand, a spiritual teacher and founder of Yoga of Immortals, delves into the transformative power of breathwork. He explains how advanced breath techniques can enhance brain function and emotional resilience. The conversation covers the significance of chanting, the mystical origins of sound, and the art of conscious dying. Ishan also shares insights on age reversal practices and contrasts breathwork with plant medicines. This engaging dialogue bridges ancient wisdom with modern wellness, emphasizing the pursuit of longevity and meaningful living.
