The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
246 snips
Oct 10, 2025 • 60min
The WATER Hack That Boosts Mitochondria by 11%! : 1343
Rowena Gates, co-founder of NanoVi and biophysics expert, discusses groundbreaking biohacking methods to enhance mitochondrial function and cellular repair. She reveals how structured water boosts oxygen efficiency and recovery in just 20 minutes. Topics include measurable improvements in VO₂ max and brain metabolism, as well as comparisons with cold therapy. Rowena also shares insights on how NanoVi complements other wellness strategies, improves mood and fatigue, and enhances resilience in high-performance training and cognitive tasks.
107 snips
Oct 9, 2025 • 50min
Digital Twins: The End of Human Drug Testing for Biohackers : 1342
In this enlightening discussion, Dr. Derya Unutmaz, a world-renowned immunologist at The Jackson Laboratory, shares insights on how AI-powered digital twins can revolutionize drug discovery and potentially eliminate human trials. He highlights the promise of personalized medicine tailored to individual biology for longevity and health. Derya also discusses the role of AGI in transforming medical practice, the need for a re-engineered immune system, and practical strategies for using compounds like metformin and GLP-1 to enhance lifespan.
138 snips
Oct 7, 2025 • 1h 3min
The Hidden Key to Pain-Free Joints (Longevity Tips) : 1341
Dr. Jason Snibbe, a board-certified orthopedic surgeon and sports medicine specialist, shares insights on maintaining healthy joints for longevity. He discusses how weak glutes and poor core stability contribute to joint issues, highlighting the importance of functional movement. Recovery techniques like stretching and cold immersions are vital for joint health. Snibbe also emphasizes wearing supportive shoes and using AI for gait analysis. The conversation wraps up on the future of robotic surgeries and the potential of biologics in orthopedic care.
41 snips
Oct 5, 2025 • 14min
Remote Work Is Making You FATTER (Do THIS to Stop It) : 1340
Working from home may seem liberating, but it disrupts your hormones and metabolism. Discover how posture and lack of movement lead to hormonal imbalances like lower testosterone and heightened cortisol levels. Learn practical posture resets to combat stress and insights on timing meals and incorporating movement to restore insulin sensitivity. Explore the power of light in regulating your hormones and how small environmental changes can boost your energy and libido without extreme dieting. It's time to biohack your remote work experience!
44 snips
Oct 3, 2025 • 10min
10-Minute Weekly Update : 1339
In just 10 minutes, dive into the latest on longevity and biohacking. Discover the truth about apple cider vinegar and its limited benefits for glucose management. Learn about the FDA's green light for NMN and how it can boost your health. Poor sleep? It could be aging your brain faster than you think. Explore the therapeutic potential of psilocybin for mood enhancement and pain relief. Plus, uncover how AI is revolutionizing early cancer detection. Get ready to upgrade your week!
60 snips
Oct 2, 2025 • 1h
How Gravity Shapes Your Body, Brain, and Health : 1338
Dr. Brennan Spiegel, a Professor at UCLA and author of 'Pull,' explores the critical yet overlooked role of gravity in human health. He discusses how gravity intolerance can manifest as obesity, fatigue, and depression. Dr. Spiegel shares insights from his research, highlighting innovative tools like weighted vests to enhance physical resilience. He connects gravity with serotonin's role in mood regulation, and explains how understanding this force can lead to better health outcomes, clearer minds, and improved performance.
116 snips
Sep 30, 2025 • 48min
Modafinil Masterclass: Clarity, Drive, and Longevity | Solo Pod : 1337
Discover the brain-boosting potential of Modafinil, a nootropic that enhances energy and focus without the jitters of caffeine. Learn how it improves cognitive functions like memory and reaction time, while also benefiting mitochondrial health and longevity. Dave shares personal experiences, scientific research, and practical tips on dosing and stack recommendations. He also contrasts Modafinil with traditional stimulants like Adderall and caffeine, providing insights into who should consider using it. Explore its real-world impact and emerging research on neuroprotection.
77 snips
Sep 28, 2025 • 11min
This Detox Organ Is Blocking Every Diet You Try (Here's The Fix) : 1336
The secret to weight loss and energy might lie in your liver. It plays a crucial role in metabolism, fat-burning, and hormone regulation. Common toxins can overwhelm this detox powerhouse, leading to sluggish bile flow and hormone imbalances. By incorporating specific nutrients and foods, like bitter greens and B vitamins, you can support liver health and detoxification. Learn practical tips to enhance bile flow and improve metabolic function. Say goodbye to stubborn weight with the right liver care!
93 snips
Sep 26, 2025 • 8min
10-Minute Weekly Update : 1335
Dive into a whirlwind of insights on longevity and health tech! Discover the reality check on rapamycin, revealing its inconsistent benefits for longevity. Learn about new precision approaches to targeting senescent cells with senolytics, ensuring tailored treatments. Explore the promising rise of AI in healthcare while addressing the crucial need for human oversight in diagnosis. Also, find out about federal pilots allowing AI to make Medicare decisions, raising important access concerns. Get actionable tips for a healthier week!
159 snips
Sep 25, 2025 • 1h 2min
Why you absolutely MUST take algae daily to protect your longevity : 1334
Catherine Arnston, the founder of ENERGYbits and a mitochondrial health expert, dives into the fascinating world of algae and its impact on longevity. She shares insights on why mitochondria decline after age 30, revealing the importance of superoxide dismutase (SOD) and glutathione in combating cellular aging. Catherine discusses her unique health regimen relying on spirulina and chlorella, and the science behind their benefits. With personal anecdotes and practical advice, this conversation serves as a guide to supercharge energy and optimize health.
