The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
Episodes
Mentioned books
135 snips
May 9, 2025 • 1h 5min
Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah : 1279
Shalin Shah, CEO of Marius Pharmaceuticals, shares insights on testosterone's crucial role in both men and women. He discusses the alarming decline of testosterone levels and why diet alone can't fix this issue. The conversation highlights the groundbreaking oral testosterone method, Kyzatrex®, which offers a safer and simpler alternative to traditional treatments. Listeners will learn about the hormone's impact on energy, mood, and longevity, along with practical advice on maintaining youthful testosterone levels for a healthier life.
109 snips
May 8, 2025 • 1h 13min
The Deadliest Room in Your House — And How to Detox It for Better Health | Aly Cohen MD : 1278
Dr. Aly Cohen, a board-certified rheumatologist and author, sheds light on the hidden dangers lurking in our homes. She reveals how common household items, from cleaning products to personal care, can disrupt hormones and contribute to autoimmune diseases. Dr. Cohen discusses microplastics and 'forever chemicals' in our environment, providing practical detox strategies to protect health and fertility. Tune in to learn how to make informed choices and create a cleaner living space for better well-being!
135 snips
May 6, 2025 • 1h 4min
Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277
Dr. Anurag Singh, Chief Medical Officer of Timeline, discusses revolutionary science in cardiovascular health. He highlights the role of mitochondria in heart failure, especially after menopause. The conversation delves into the benefits of Urolithin A, a potent molecule that rejuvenates mitochondrial function and may reverse markers of cardiac aging. Dr. Singh also shares lifestyle biohacks that can enhance heart resilience and improve overall healthspan, all while promoting endurance and cellular nutrition.
84 snips
May 1, 2025 • 41min
How Laser Therapy Boosts Mood, Mental Clarity, and Consciousness with Dr. Brandon Crawford : 1276
Dr. Brandon Crawford, a neurotherapist and founder of 528 Innovations, discusses how laser therapy can revolutionize mental health and consciousness. He explains how targeted light can rewire brainwaves, aid recovery from conditions like autism and ALS, and even activate the vagus nerve. Listeners will be fascinated by the idea that specific laser frequencies can improve mood and gut-brain communication. Crawford shares his insights on the intersection of emotion, biology, and quantum science, portraying a new approach to mental wellness through innovative light-based therapies.
125 snips
Apr 29, 2025 • 1h 43min
Conscious Bacteria? The Secret New Science of Cellular Intelligence | Zach Bush : 1275
Zach Bush, MD, a trailblazer in cellular intelligence, reveals how mitochondria can act as conscious messengers rather than mere energy producers. He discusses the symbiotic relationship between our microbiome and health, illustrating how disrupted cellular communication is linked to chronic diseases. The conversation also explores how emotional trauma affects genetic expression and mitochondrial function. Bush emphasizes the importance of restoring connections within ecosystems and the human body for optimal well-being, advocating for a holistic approach to health that embraces ancient wisdom.
208 snips
Apr 25, 2025 • 1h 6min
The End of Cardio? Burn Fat & Boost VO₂ Max in Just 8 Minutes a Week – with REHIT | Ulrich Dempfle : 1275
Ulrich Dempfle, a German-trained engineer and co-founder of CAROL Bike, introduces a revolutionary workout method called REHIT. This new approach dismantles outdated cardio advice, promoting short, 8-minute sessions that significantly improve VO₂ max and reduce diabetes risk. Dempfle discusses how REHIT outperforms traditional jogging, offers enormous fitness gains, and even benefits perimenopausal women. He also shares insights on personalizing workouts with AI, emphasizing the importance of fun and adherence for lasting fitness results.
120 snips
Apr 24, 2025 • 1h 19min
The Real Reason You Still Feel Tired—Even When Your Bloodwork Looks Perfect | Dr Pompa : 1273
Dr. Daniel Pompa, a leader in cellular detox and root-cause healing, discusses the hidden health issues causing chronic fatigue despite normal bloodwork. He reveals how cellular dysfunction, neurotoxicity, and hormone resistance sabotage energy and well-being. The conversation explores the dangers of toxins like glyphosate, the importance of detoxing at a cellular level, and the role of dietary fats in inflammation. Dr. Pompa emphasizes a holistic approach to health, advocating for truly understanding and addressing the root causes over merely treating symptoms.
71 snips
Apr 22, 2025 • 1h 20min
The $500 Billion Secret: Why Top Leaders Chase Stress | Sébastien Page : 1272
Sébastien Page, CIO of a major investment firm and author of 'The Psychology of Leadership', discusses how top leaders leverage stress instead of shying away from it. He uncovers why zero stress can lead to burnout and explores the pivotal role of strategic patience in decision-making. Sébastien shares fascinating insights about how losses can fuel mastery, the balance between intuition and analysis, and the importance of kindness over mere niceness in leadership. This conversation is a masterclass in transforming pressure into productivity.
59 snips
Apr 17, 2025 • 1h 30min
Web3 & the Future of Genetics: AI, Blockchain & Data Ownership with Nillion : 1271
Michael Tiffany, Co-founder and CEO of Fulcra Dynamics, dives deep into the future of personal data ownership alongside fellow innovator Vishakh. They discuss how technologies like Nillion allow secure use of genetic data without compromising privacy. Tiffany reveals the shocking truth about government access to DNA and the revolutionary potential of decentralized networks. The duo explores the concept of a 'cybernetic operating system' and its implications for health freedom, encouraging listeners to reclaim their data in the era of biohacking.
160 snips
Apr 15, 2025 • 54min
Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270
Join Dr. Steven Gundry, a leading heart surgeon and author of The Plant Paradox, as he explores the powerful connection between our gut microbiome and mental health. Discover how gut bacteria can influence your thoughts and cravings, potentially hijacking your brain. Dr. Gundry reveals shocking insights about the effects of antibiotics, glyphosate, and processed foods on gut health. He discusses how specific microbes can lead to addiction and obesity, and offers strategies for rebuilding your gut ecosystem through better dietary choices.
