
The Joe Cohen Show
Unlock the secrets of your DNA and optimize your health with The Joe Cohen Show. Join Joe, biohacker and founder of SelfDecode, as he interviews world-class health experts and shares cutting-edge research and strategies for biohacking your body and brain. From functional medicine tips and supplement recommendations to longevity and performance optimization, each episode is packed with insights to help you achieve your health goals. Whether you're interested in genetics, biohacking, alternative health, or simply improving your overall wellness, this podcast has something for you. Subscribe now!
Latest episodes

8 snips
Mar 15, 2024 • 1h 6min
Mastering Skin Health: Essential Biohacks and Skincare Secrets with Amitay Eshel
Discover essential biohacks and skincare secrets for mastering skin health with expert Amitay Eshel. Topics include the science of skincare ingredients, impact of sun exposure, innovative anti-aging approaches, importance of vitamins and metabolites, and personalized skincare regimens.

Mar 12, 2024 • 4min
Navigating your Circadian Rhythm, Sleep, and CLOCK Gene | SNPit #12
Discover how the CLOCK and PER2 genes influence circadian rhythms, sleep patterns, and health conditions. Explore genetic variations affecting sleep duration, activity patterns, and tendency to be an early riser or night owl. Learn about the role of genes in optimizing sleep and aligning with the body's internal clock.

20 snips
Mar 8, 2024 • 1h 37min
The Science of Methylation and MTHFR with Dr. Ben Lynch
Dr. Ben Lynch discusses methylation pathways, homocysteine, and personalized supplement recommendations. They explore the role of B vitamins, epigenetics, and alternative tests. Topics include nitrous oxide exposure, folate metabolism, histidine supplementation, and optimizing health with data-driven decisions.

Mar 6, 2024 • 4min
SNPit #11 | A Gene That Affects Longevity More Than Smoking?
In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life.
But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years?
We uncover the research behind this startling revelation and discuss the implications for our health and well-being.
Plus, we reveal actionable steps you can take to optimize your FOXO3 gene for better longevity.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
- Check out SelfDecode: https://selfdecode.com/
- Join Joe’s online community: https://thejoecohenshow.com/

13 snips
Mar 1, 2024 • 53min
A Deep-Dive Into Gut Health And Microbiome With Michael Smith
Join Joe Cohen as he explores gut health and the microbiome with naturopath Michael Smith. They discuss strategies for enhancing gut health, addressing chronic conditions, and the pivotal role of lifestyle changes in achieving optimal well-being. Learn about specialized testing, personalized recommendations, and the impact of butyrate and resistant starch on gut health.

4 snips
Feb 23, 2024 • 55min
Top 6 Health Transformation Tips You Need To Hear
Discover top health tips from Season 5, including methylation, lab levels, longevity interventions, food sensitivities, and mitochondrial health. Learn about optimizing health through nutrient balance and the importance of B vitamins for energy and immune function.

10 snips
Feb 16, 2024 • 28min
Master The 3 Pillars Of Immune Health
Learn how to support your immune system by optimizing the mitochondria, extracellular matrix, and inflammation. Discover the importance of B vitamins, collagen, and sulfur in immune health. Explore key supplements like zinc, vitamin A, and vitamin D that can enhance immune function.

Feb 14, 2024 • 6min
SNPit #10 | Understanding Appetite, Emotional Eating, and Fat Metabolism
The guest on this episode is the FTO gene, which plays a pivotal role in fat metabolism, appetite, weight management, emotional eating, and hunger levels. They discuss how variants of the FTO gene influence emotional eating, pleasure from eating, and appetite. The podcast explores the impact of the FTO gene on appetite, emotional eating, and fat metabolism, and emphasizes that negative effects can be counteracted through awareness and lifestyle changes.

Feb 9, 2024 • 1h 8min
Exploring Rapamycin, Longevity and Healthspan with Dr. Matt Kaeberlein
Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, discusses the potential of rapamycin for longevity and healthspan. He explains the biological mechanisms, optimal dosing, and effects on the immune system. They also explore aging clocks, biomarkers, and the significance of the microbiome in aging research. Visit OptiSpan.life for more information.

10 snips
Feb 2, 2024 • 48min
A Practical Guide to Lab Tests for Optimal Health
Discover the crucial role of lab tests in understanding health. Explore essential lab markers like Complete Metabolic Panel and Thyroid Panel. Learn about the limitations of standard tests and the benefits of advanced tools like SelfDecode. Hear about the mistakes people make when taking lab tests and the lab tests Joe takes every quarter.