
The Joe Cohen Show
Unlock the secrets of your DNA and optimize your health with The Joe Cohen Show. Join Joe, biohacker and founder of SelfDecode, as he interviews world-class health experts and shares cutting-edge research and strategies for biohacking your body and brain. From functional medicine tips and supplement recommendations to longevity and performance optimization, each episode is packed with insights to help you achieve your health goals. Whether you're interested in genetics, biohacking, alternative health, or simply improving your overall wellness, this podcast has something for you. Subscribe now!
Latest episodes

Jan 30, 2024 • 4min
SNPit #09 | How Your Body Uses Vitamin D & The VDR Gene
Explore the pivotal role of Vitamin D in optimizing health and well-being. Delve into the fascinating journey of Vitamin D synthesis and the activation of calcitriol. Understand the significance of the VDR gene in the body's utilization of vitamin D and its effects on metabolic pathways, calcium levels, and cell growth. Learn how understanding genetic variants in the VDR gene can customize diet and lifestyle adjustments for optimal health.

Jan 26, 2024 • 1h 13min
Energy, Mental Clarity and NAD: Biohacking with James Schmachtenberger
Join successful biohacker and CEO of Neurohacker Collective, James Schmachtenberger, as he shares his journey with biohacking for improved energy and cognitive function. Discover the transformative effects of NADIV treatment, the importance of research and software solutions, and the impact of lifestyle changes and supplementation on optimizing health.

Jan 23, 2024 • 3min
SNPit #08 | The IL6 Puzzle: Unraveling Genetic Threads of Immunity
Geneticist specializing in immunology discussed the IL6 gene and its impact on immunity, inflammation, and health conditions like acne and longevity. Specific gene variants, such as rs1800795 and rs1800796, were explored in relation to immune response, susceptibility to infections, muscle recovery, and inflammatory diseases.

7 snips
Jan 19, 2024 • 1h 50min
Biohacking Longevity: Navigating Lab Tests, Supplements, and Lifestyle for Optimal Aging w/ Michael Lustgarten
Join Dr. Michael Lustgarten as he discusses the importance of lab tests and markers for longevity, the impact of supplements on mortality risk, and the connection between fiber intake and cholesterol levels. Explore the effects of high soluble fiber diet on gut muscle axis, and learn about strategies for calorie restriction and circadian alignment for optimal aging.

Jan 16, 2024 • 5min
SNPit #07 | Can This Gene Help With Your Body’s Detox?
Discover the transformative potential of the UGT1A1 gene in detoxifying the body. Learn about Glucuronidation, a chemical reaction that enhances detox. Explore the impact of genetic variations on the body's detox capabilities. Unveil practical solutions to support natural detoxification processes.

4 snips
Jan 12, 2024 • 32min
How to Optimize Your Methylation
Learn about the tests for methylation levels and the impact of genetic variations on nutrient needs. Discover the significance of folate and B12 supplementation and the benefits of TMG and choline. Understand the importance of optimizing methylation and homocysteine levels with B vitamins, exercise, and stress reduction. Explore the challenges in achieving optimal methylation and the effects of toxins. Find out how SelfDecode can help assess and optimize methylation using genetic variants.

Jan 9, 2024 • 6min
SNPit #06 | PEMT, Choline, and Cellular Health
Delve into the significance of choline and how it impacts cellular health and brain function, and how PEMT plays a role in choline production. Discover the intricate genetic variants within PEMT and how certain alleles influence susceptibility to choline deficiency. Learn how estrogen stimulation poses unique challenges for different demographics.

9 snips
Jan 5, 2024 • 1h 1min
Boosting Immunity and Biohacking to Prevent Illness with Dr. Oz
Renowned doctor and TV personality Dr. Oz joins Joe Cohen to discuss boosting immunity and biohacking. Topics include preferred testing methods, DNA-based cancer testing, safe drugs for immunity, peptides for recovery, hot baths for colds, and IV therapy for prevention.

Dec 29, 2023 • 24min
Navigating Your MTHFR Gene: Essential Lab Markers and Ideal Supplements for Support
Explore the fascinating world of MTHFR gene variations and their impact on our health. Learn about folate metabolism and the crucial role of methylation. Dive deep into the science behind MTHFR and discover practical tips for optimizing your folate levels. Get insights on methylfolate benefits and the connection between homocysteine and methylation. Find out about recommended supplements and dietary approaches for supporting healthy methylation and learn about the significance of B vitamins for optimal health.

Dec 15, 2023 • 5min
SNPit #05 | Do MTR & MTRR Deserve as Much Attention as MTHFR?
Discover the forgotten genes in methylation, MTR and MTRR, and how they affect homocysteine levels. Learn why homocysteine is important and how genetic variants can impact methylation.