The Joe Cohen Show SNPit #05 | Do MTR & MTRR Deserve as Much Attention as MTHFR?
Dec 15, 2023
Discover the forgotten genes in methylation, MTR and MTRR, and how they affect homocysteine levels. Learn why homocysteine is important and how genetic variants can impact methylation.
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MTR & MTRR's Role in Methylation
- MTR and MTRR genes are crucial players in the methylation process alongside MTHFR.
- They help convert homocysteine to methionine, influencing heart and mental health.
How MTR & MTRR Enzymes Work
- MTR codes methionine synthase, which needs methylcobalamin (B12) and an enzyme from MTRR to reduce homocysteine.
- MTRR codes methionine synthase reductase, supporting MTR enzyme function to maintain healthy homocysteine levels.
Homocysteine's Health Importance
- Homocysteine levels are linked to diseases like heart disease and dementia and reflect B-vitamin status.
- Variants in MTR and MTRR genes influence methylation efficiency and homocysteine levels in the body.