The Joe Cohen Show

In this solo episode, Joe Cohen explores the powerful effects of glutamate on the brain and how elevated levels can drive anxiety, obsessive thoughts, and overstimulation. He shares insights from personal experiments with supplements like AKG, proline, and arginine and explains how they impacted his mental state, motivation, and focus.Joe also breaks down the symptoms tied to excess glutamate, from headaches and insomnia to mood swings and neurological issues. He discusses why certain people are more sensitive to glutamate due to genetic differences, and outlines what’s helped him manage it, including specific doses of NAC, glycine, B6, vitamin C, and more.This episode offers a practical, firsthand look at how glutamate functions, what throws it out of balance, and what can be done to bring it under control.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:00) - Introduction(00:16) - Understanding Glutamate and Its Effects(04:32) - Personal Experiments with Glutamate(08:22) - Supplements and Strategies to Lower Glutamate(18:31) - Symptoms and Conditions Related to High Glutamate(20:20) - Genetic Factors and Glutamate(22:13) - Conclusion

In this eye-opening episode of The Joe Cohen Show, Joe sits down with microbiologist and biotech entrepreneur Kiran Krishnan to dismantle the myths and marketing hype surrounding microbiome testing. Drawing parallels between the DNA and microbiome industries, they expose the scientific shortcuts, technological flaws, and misleading health claims being sold to consumers.Krishnan, the mind behind one of the few microbiome platforms used in published research, breaks down what a legitimate test looks like and why most tests on the market fall short, sometimes by as much as 70% in accuracy. The conversation also explores probiotics in depth, why strain specificity matters, and how consumers can make more informed decisions when navigating this complex and evolving space.Whether you’re a health professional or someone trying to optimize your gut, this episode will help you separate science from sales.📌 Topics covered: microbiome testing technology, bioinformatics, probiotic strains, sequencing methods, red flags in wellness tech- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ (00:00) - Introduction to the Joe Cohen Show(00:16) - Meet Kiran Krishnan(01:07) - Understanding Microbiome Testing(03:01) - The Importance of Whole Genome Sequencing(04:48) - Challenges in Microbiome and Genetic Testing(05:42) - Critique of 16S Ribosomal RNA Sequencing(11:58) - Issues with Viome and Other Testing Companies(21:14) - Complexities of Microbiome Mapping(23:27) - Validating Microbiome Tests(27:04) - The Future of Microbiome Technology(28:10) - Advancements in Genome Sequencing(29:18) - Challenges in Microbiome Analysis(30:40) - Economic Realities of Sequencing(31:57) - Company Strategies and Ethics(33:49) - Benefits of Microbiome Testing(35:12) - Probiotics and Gut Health(38:20) - Top Probiotic Strains(43:00) - Importance of Specific Strains(52:52) - Concluding Thoughts on Probiotics

Most genetic testing companies promise personalized health insights, but their reports barely scratch the surface, often analyzing just a handful of genetic variants. In this episode, Joe Cohen shares what happened when the SelfDecode team took a close look at dozens of these reports to understand how and why they fall short and what it actually takes to do it right.He shares how SelfDecode analyzes hundreds of thousands (sometimes millions) of variants per report, uses advanced technology to generate more accurate results, and integrates labs and lifestyle data to deliver truly actionable recommendations. If you've ever wondered whether your DNA test was worth the money, this episode is a must-listen.- Check out the SelfDecode Report Shop: https://selfdecode.com/shop/- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ (00:00) - Introduction(00:16) - Overview of Genetic Reports(01:26) - Competitor Analysis and 100X Series(02:34) - Detailed Breakdown of Genetic Reports(03:27) - Recreating Competitor Reports(08:57) - Final Thoughts

In this episode, Joe Cohen talks with Mark Notton, founder of Revive DNA, about how your DNA can shape your sleep, energy, and long-term health.After helping his wife recover from a chronic autoimmune condition using a personalized nutrition approach, Mark left his executive career at Samsung to launch a health tech company.Now, Revive DNA is making science-backed, DNA-driven wellness accessible to more people with support from major institutions and powered by OmicsEdge technology.Tune in for a deep dive into the future of personalized health and what most programs are still getting wrong.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:00) - Introduction(00:16) - Meet Mark Noten: Founder of Revive DNA(01:06) - Mark's Journey into the Health Space(02:09) - A Personal Health Crisis: Mark's Wife's Story(04:40) - The Role of DNA in Health and Nutrition(06:44) - Revive DNA: Technology and Partnerships(11:53) - Revive DNA App: Features and Benefits(19:31) - Upcoming Sleep Study with Samsung(28:43) - Future Directions and Closing Remarks

In this episode, Joe discusses the benefits of the probiotic L. Plantarum, specifically the 299V strain. He talks about its effectiveness in reducing gas, improving mood, exercise recovery, and more. He shares how he personalizes his probiotic routine using SelfDecode, why the specific strain matters more than the brand, and how he takes higher doses to really feel a difference. If you're dealing with gut issues or just want to understand how probiotics can affect things like immunity, allergies, mood, or even homocysteine levels, there’s a lot in here you’ll find useful.Tune in to learn more about optimizing your health with probiotics and get personalized recommendations from SelfDecode.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:00) - Introduction(00:16) - Discussing L. Plantarum and Probiotic Recommendations(01:28) - Joe’s Personal Experiences with Probiotics(05:28) - Benefits of L. Plantarum(07:43) - Research and Evidence on L. Plantarum(09:56) - L. Plantarum's Impact on Various Health Conditions(12:01) - Probiotics and Skin Health(13:56) - Probiotics and Metabolic Health(18:56) - Final Thoughts and Recommendations

Join Joe Cohen in this insightful episode as he interviews Martin Kremmer, CEO and co-founder of BioWatch and FreeAge. Martin, a pioneer in the Danish biohacking scene, shares his company's innovative approach to DNA and epigenetic testing to develop personalized longevity plans. They discuss the importance of combining different types of data, the future of functional health, and the role of stress management in achieving optimal health. Martin also introduces the Copenhagen Health Week and emphasizes the significance of simple lifestyle changes for long-term health. Don't miss this comprehensive talk on biohacking, health tech, and much more.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ 

Is Bryan Johnson’s anti-aging regimen the ultimate blueprint for health, or just another one-size-fits-all approach? In this episode, Joe Cohen breaks down Johnson’s protocol, highlighting what works, what doesn’t, and why personalization is key.Joe shares his own experiences and expert insights to help you optimize your health on your own terms.- Discover the pros and cons of Bryan Johnson’s approach- Why personalization matters more than a strict regimen- The best practices for sleep, nutrition, and longevityJoin us for a deep dive into the science behind health optimization!- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:20) - Brian Johnson's Blueprint: An Overview(00:48) - Personalization in Health Protocols(01:04) - Sleep and Eating Habits(03:31) - Critique of Calorie Restriction(05:10) - Protein Intake and Muscle Building(08:20) - Skepticism on Brian Johnson's Regimen(15:50) - Supplement Analysis: Ingredients and Dosages(25:31) - Joe's Personal Supplement Routine(28:21) - Blueprint Product Reviews(32:43) - Evaluating Niacin and B Vitamins(34:21) - Zinc, Selenium, and Genetic Predispositions(35:21) - Personal Dosage Preferences(37:03) - Critique of Supplement Formulas(37:42) - Advanced Supplements and Personal Experiences(54:50) - Dietary Choices and Sensitivities(57:29) - Exercise and Lifestyle Recommendations

In this episode, Joe Cohen sits down with Dr. Brigitte Hanly, CEO, Chief Scientist, and co-founder of Stemaid Institute, to explore the cutting-edge world of stem cell therapy. They discuss how pluripotent stem cells and exosomes can optimize health, repair injuries, and even slow aging. Joe shares his firsthand experience with the treatments, including their impact on immune function, brain health, and inflammation. Plus, they dive into the ethics of stem cell research and the future of regenerative medicine. If you’re curious about biohacking, longevity, and the science behind cellular rejuvenation, this is an episode you don’t want to miss!- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ 

Discover the incredible potential of the probiotic L. reuteri and how it can revolutionize your gut health. The discussion delves into its surprising benefits, including lowering cholesterol and easing food sensitivities. Personal experiments reveal its impact on digestion, inflammation, and even skin health. Tune in to understand why this specific strain might be a game changer for your wellness routine!

Dr. Elena Gross joins Joe Cohen to share her journey from debilitating chronic migraines to becoming a neuroscience researcher and entrepreneur. They explore the role of mitochondrial dysfunction in migraines, how ketosis can optimize brain energy, and the importance of personalized health approaches. Joe and Elena break down the science behind oxidative stress, genetic risk factors, and key nutrients that support migraine management. Tune in for expert insights on biohacking migraines and optimizing your brain health!- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(04:41) - Ketosis and Heavy Metal Poisoning(06:18) - Mitochondrial Dysfunction and Migraines(07:27) - The Role of Neurotransmitters and Inflammation(10:27) - Energy Deficiency and Brain Function(22:04) - Genetic Factors and Environmental Triggers(24:37) - Managing Migraines in Today's World(36:25) - Understanding Migraine Triggers(36:48) - Genetic Factors and Pathways(37:28) - Migraine Diary and Identifying Triggers(38:12) - Hormonal and Metabolic Influences(38:31) - Nutritional Supplements and Ketone Bodies(39:25) - Clinical Trials and Research Insights(41:32) - Personal Experiences with Treatments(42:01) - Alternative Therapies and Lifestyle Changes(48:28) - Genetic Testing and Personalized Medicine(57:15) - Mitochondrial Function and Chronic Conditions