
The Joe Cohen Show
Unlock the secrets of your DNA and optimize your health with The Joe Cohen Show. Join Joe, biohacker and founder of SelfDecode, as he interviews world-class health experts and shares cutting-edge research and strategies for biohacking your body and brain. From functional medicine tips and supplement recommendations to longevity and performance optimization, each episode is packed with insights to help you achieve your health goals. Whether you're interested in genetics, biohacking, alternative health, or simply improving your overall wellness, this podcast has something for you. Subscribe now!
Latest episodes

9 snips
May 30, 2025 • 1h 12min
Detoxification, Biohacking & Liposomal Supplements Explained with Dr. Chris Shade
Join Joe Cohen on The Joe Cohen Show as he speaks with Dr. Chris Shade, founder and CEO of Quicksilver Scientific. In this insightful episode, they dive deep into the world of biohacking, detoxification, and the science behind liposomal supplements. Dr. Shade explains the intricacies of mercury detox, the role of glutathione, the benefits of liposomal delivery systems, and how certain supplements can optimize health. They also discuss the challenges of current detoxification methods and the incredible advancements in the field, including liposomal technology for enhanced absorption and effectiveness. This episode is a must-watch for anyone interested in cutting-edge health optimization techniques.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:00) Introduction to the Joe Cohen Show(00:17) Meet Dr. Chris Shade(01:24) The Journey to Healthcare and Detoxification(02:40) Understanding Liposomes and Their Importance(05:19) Challenges in Liposomal Supplementation(10:38) Comparing Glutathione and NAC(14:37) The Power of Liposomal Delivery Systems(34:43) Detoxification and Mercury Testing(37:38) Understanding Mercury Detoxification(37:52) The Role of Glutathione in Detox(38:30) Detoxification Protocols and Binders(39:24) Urine Testing and Mercury Measurement(39:53) Challenge Testing and Its Limitations(43:30) Kidney and Liver Function in Detox(53:07) The Importance of NRF2 Upregulation(57:52) The Role of Bile Flow in Detox(01:00:12) Advanced Detoxification Techniques(01:08:03) Microplastics and Plasma Exchange(01:10:34) Where to Find Detox Products

May 23, 2025 • 37min
Understanding Functional Medicine with Dr. Ben Weitz
Joe Cohen talks with Dr. Ben Weitz, a functional medicine practitioner with over 35 years of experience, about his approach to addressing gut health and autoimmune conditions.Ben explains how functional medicine focuses on finding and treating root causes, such as diet, lifestyle, microbiome imbalances, and chronic infections, rather than just managing symptoms. They discuss how conditions like IBS and autoimmune diseases are connected to factors like food sensitivities, toxins, and gut health, and explore various testing methods and treatment strategies. Ben also shares practical insights from his clinical practice and ongoing work in the functional medicine community.Tune in to learn how functional medicine practitioners approach complex health issues and what steps you can take to support your gut and immune health.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:00) Introduction(00:16) Meet Functional Medicine Practitioner Dr. Ben Weitz(01:20) Understanding Functional Medicine(02:03) Exploring Gut Health and IBS(05:09) Autoimmune Diseases: Functional vs. Conventional Medicine(09:40) Case Studies and Practical Applications(12:21) Debating the Validity of Functional Medicine Tests(19:12) Understanding Histidine and Folate Correlation(20:00) Critique of Biochemical Assumptions in Testing(21:01) Genetic Conditions and Functional Medicine Tests(23:02) Protein Consumption and Metabolite Variability(23:19) Legitimate Tests and Their Validity(27:37) Stool Testing and Gut Health(30:54) Addressing Autoimmune Diseases and Chronic Infections(35:59) Conclusion

May 16, 2025 • 47min
How to Boost Stem Cells Naturally for Better Healing and Aging with Christian Drapeau
Joe sits down with Christian Drapeau, a stem cell expert with over 20 years of research under his belt, to talk about how the body repairs itself, and how we can help it do a better job. They get into what stem cells actually do, why we lose them as we age, and how that affects recovery, energy, and long-term health. Christian shares simple, natural ways to support stem cell activity, like fasting, exercise, and plant-based supplements. They also talk about stem cell therapies and how they compare to everyday strategies you can use to support your body’s natural repair system.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/Timestamps: (00:00) Introduction to the Joe Cohen Show(00:17) Meet Christian Drapeau(01:14) Understanding Stem Cells and Their Benefits(02:00) Natural Ways to Increase Stem Cells(06:44) Stem Cells and Longevity(12:19) Stem Cell Supplements vs. Injections(23:42) Hyperbaric Chambers and Stem Cells(25:32) Understanding Hyperbaric Chambers(26:45) Introduction to Stem Cell Enhancing Plants(27:13) Top Plants for Increasing Stem Cells(28:00) Mechanisms and Effects of Specific Plants(32:45) Combining Plants for Optimal Stem Cell Release(34:35) Active Compounds in Stem Cell Enhancing Plants(41:59) Stem Cell Supplements and Their Benefits(46:08) Conclusion and Further Resources

4 snips
May 9, 2025 • 24min
Can Supplements Make You More Monogamous?
Dive into the intriguing interplay between biology and relationships. Discover how the hormone vasopressin influences feelings of attachment and loyalty. Learn about surprising findings from animal studies and personal anecdotes surrounding dietary supplements. Hear about one individual's experience with L-arginine and glycine, revealing a potential shift towards monogamy. This blend of science, personal stories, and biohacking offers a fascinating look at what drives our romantic choices.

May 2, 2025 • 47min
A Practitioner’s Guide to Personalized Health
Joline Schaaphok, a health coach specializing in personalized insights through genetic data, joins the discussion to decode health mysteries. They dive into genetic results, revealing tailored macronutrient and supplement recommendations. Joline uncovers food sensitivities and addresses overlooked risks like anemia and cardiovascular health. The conversation emphasizes the power of combining genetic insights with lifestyle choices for meaningful health improvements. It's a treasure trove of actionable strategies for anyone interested in precision health!

Apr 25, 2025 • 1h 9min
How DNA Data is Revolutionizing Personalized Medicine with Sasha Powell
In this episode of the Joe Cohen Show, host Joe Cohen discusses the power of biohacking and precision health with Sasha Powell, a nurse practitioner and integrative healthcare provider. Sasha shares her experience using DNA data to optimize her patients' health outcomes, focusing on areas like hormone and weight management, mental health, and overall well-being. They dive into the specifics of how genetic insights can personalize treatment plans, leading to better, faster results. Whether it's diagnosing mental health issues more accurately or managing physical health conditions like diabetes and inflammation, Sasha highlights the transformative impact of personalized medicine. Tune in to understand why integrating genetic information into healthcare is not just an innovation but a necessity.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamp:(00:00) - Introduction to the Joe Cohen Show(00:16) - Meet Sasha Powell(00:56) - Using DNA for Personalized Health Solutions(01:24) - Weight and Hormone Management Strategies(03:11) - Blood Sugar Regulation and Diet Recommendations(07:25) - Mental Health and Genetic Insights(10:59) - The Role of Neurochemistry in Treatment Plans(13:48) - Personalized Supplement Recommendations(30:10) - The Importance of Methylation in Health(34:03) - Utilizing Self Decode for Comprehensive Health Management(38:31) - Optimizing Quality of Life(39:06) - Longevity Screener Insights(39:34) - Clinical Overview Report(40:30) - Health Overview Report(41:44) - Lab Data and Clinical Recommendations(45:15) - Family Planning and Genetic Risks(45:57) - Integrating Lab Tests and Genetic Data(48:44) - Using SelfDecode in Clinical Practice(58:56) - The Future of Healthcare with AI(01:04:26) - Organic Acids Test and Lab Considerations(01:08:08) - Concluding Thoughts and Recommendations

5 snips
Apr 22, 2025 • 23min
Understanding Glutamate: Anxiety, OCD, and Brain Health
In this solo episode, Joe Cohen explores the powerful effects of glutamate on the brain and how elevated levels can drive anxiety, obsessive thoughts, and overstimulation. He shares insights from personal experiments with supplements like AKG, proline, and arginine and explains how they impacted his mental state, motivation, and focus.Joe also breaks down the symptoms tied to excess glutamate, from headaches and insomnia to mood swings and neurological issues. He discusses why certain people are more sensitive to glutamate due to genetic differences, and outlines what’s helped him manage it, including specific doses of NAC, glycine, B6, vitamin C, and more.This episode offers a practical, firsthand look at how glutamate functions, what throws it out of balance, and what can be done to bring it under control.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:00) - Introduction(00:16) - Understanding Glutamate and Its Effects(04:32) - Personal Experiments with Glutamate(08:22) - Supplements and Strategies to Lower Glutamate(18:31) - Symptoms and Conditions Related to High Glutamate(20:20) - Genetic Factors and Glutamate(22:13) - Conclusion

10 snips
Apr 18, 2025 • 55min
The Truth About Microbiome Testing with Kiran Krishnan
In this eye-opening episode of The Joe Cohen Show, Joe sits down with microbiologist and biotech entrepreneur Kiran Krishnan to dismantle the myths and marketing hype surrounding microbiome testing. Drawing parallels between the DNA and microbiome industries, they expose the scientific shortcuts, technological flaws, and misleading health claims being sold to consumers.Krishnan, the mind behind one of the few microbiome platforms used in published research, breaks down what a legitimate test looks like and why most tests on the market fall short, sometimes by as much as 70% in accuracy. The conversation also explores probiotics in depth, why strain specificity matters, and how consumers can make more informed decisions when navigating this complex and evolving space.Whether you’re a health professional or someone trying to optimize your gut, this episode will help you separate science from sales.📌 Topics covered: microbiome testing technology, bioinformatics, probiotic strains, sequencing methods, red flags in wellness tech- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ (00:00) - Introduction to the Joe Cohen Show(00:16) - Meet Kiran Krishnan(01:07) - Understanding Microbiome Testing(03:01) - The Importance of Whole Genome Sequencing(04:48) - Challenges in Microbiome and Genetic Testing(05:42) - Critique of 16S Ribosomal RNA Sequencing(11:58) - Issues with Viome and Other Testing Companies(21:14) - Complexities of Microbiome Mapping(23:27) - Validating Microbiome Tests(27:04) - The Future of Microbiome Technology(28:10) - Advancements in Genome Sequencing(29:18) - Challenges in Microbiome Analysis(30:40) - Economic Realities of Sequencing(31:57) - Company Strategies and Ethics(33:49) - Benefits of Microbiome Testing(35:12) - Probiotics and Gut Health(38:20) - Top Probiotic Strains(43:00) - Importance of Specific Strains(52:52) - Concluding Thoughts on Probiotics

Apr 15, 2025 • 9min
The DNA Testing Industry Is Broken. Here's What We're Doing About It
Most genetic testing companies promise personalized health insights, but their reports barely scratch the surface, often analyzing just a handful of genetic variants. In this episode, Joe Cohen shares what happened when the SelfDecode team took a close look at dozens of these reports to understand how and why they fall short and what it actually takes to do it right.He shares how SelfDecode analyzes hundreds of thousands (sometimes millions) of variants per report, uses advanced technology to generate more accurate results, and integrates labs and lifestyle data to deliver truly actionable recommendations. If you've ever wondered whether your DNA test was worth the money, this episode is a must-listen.- Check out the SelfDecode Report Shop: https://selfdecode.com/shop/- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ (00:00) - Introduction(00:16) - Overview of Genetic Reports(01:26) - Competitor Analysis and 100X Series(02:34) - Detailed Breakdown of Genetic Reports(03:27) - Recreating Competitor Reports(08:57) - Final Thoughts

Apr 11, 2025 • 33min
The Future of Personalized Health and Nutrition with Mark Notton
In this episode, Joe Cohen talks with Mark Notton, founder of Revive DNA, about how your DNA can shape your sleep, energy, and long-term health.After helping his wife recover from a chronic autoimmune condition using a personalized nutrition approach, Mark left his executive career at Samsung to launch a health tech company.Now, Revive DNA is making science-backed, DNA-driven wellness accessible to more people with support from major institutions and powered by OmicsEdge technology.Tune in for a deep dive into the future of personalized health and what most programs are still getting wrong.- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/ Timestamps:(00:00) - Introduction(00:16) - Meet Mark Noten: Founder of Revive DNA(01:06) - Mark's Journey into the Health Space(02:09) - A Personal Health Crisis: Mark's Wife's Story(04:40) - The Role of DNA in Health and Nutrition(06:44) - Revive DNA: Technology and Partnerships(11:53) - Revive DNA App: Features and Benefits(19:31) - Upcoming Sleep Study with Samsung(28:43) - Future Directions and Closing Remarks