Understanding Glutamate: Anxiety, OCD, and Brain Health

In this solo episode, Joe Cohen explores the powerful effects of glutamate on the brain and how elevated levels can drive anxiety, obsessive thoughts, and overstimulation. 

He shares insights from personal experiments with supplements like AKG, proline, and arginine and explains how they impacted his mental state, motivation, and focus.

Joe also breaks down the symptoms tied to excess glutamate, from headaches and insomnia to mood swings and neurological issues. He discusses why certain people are more sensitive to glutamate due to genetic differences, and outlines what’s helped him manage it, including specific doses of NAC, glycine, B6, vitamin C, and more.

This episode offers a practical, firsthand look at how glutamate functions, what throws it out of balance, and what can be done to bring it under control.

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Timestamps:

(00:00) - Introduction

(00:16) - Understanding Glutamate and Its Effects

(04:32) - Personal Experiments with Glutamate

(08:22) - Supplements and Strategies to Lower Glutamate

(18:31) - Symptoms and Conditions Related to High Glutamate

(20:20) - Genetic Factors and Glutamate

(22:13) - Conclusion