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The Joe Cohen Show
Exploring Rapamycin, Longevity and Healthspan with Dr. Matt Kaeberlein
Feb 9, 2024
Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, discusses the potential of rapamycin for longevity and healthspan. He explains the biological mechanisms, optimal dosing, and effects on the immune system. They also explore aging clocks, biomarkers, and the significance of the microbiome in aging research. Visit OptiSpan.life for more information.
01:08:19
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Quick takeaways
- Rapamycin has shown positive effects on longevity and organ function, particularly the immune system, when administered starting in middle age.
- The lack of financial incentive for large clinical trials and concerns about immunosuppression present challenges to the research and acceptance of rapamycin as an anti-aging intervention.
Deep dives
The Benefits and Efficacy of Rapamycin in Aging
Rapamycin is considered the gold standard in longevity interventions due to its extensive preclinical studies that demonstrate increased lifespan and delayed aging in various model systems. Unlike many other interventions, rapamycin has consistently shown positive effects on longevity when administered starting in middle age. It has been observed to reverse functional declines in organs and tissues, such as the heart and immune system, within short periods of treatment. While the optimal dose for longevity is still uncertain, the widely used dose of six milligrams once a week in humans has been associated with improved immune response and reduced infection risk. However, caution is advised as higher doses and daily use may lead to side effects such as metabolic dysregulation and increased risk of infection.
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