The Science of Methylation and MTHFR with Dr. Ben Lynch
Mar 8, 2024
auto_awesome
Dr. Ben Lynch discusses methylation pathways, homocysteine, and personalized supplement recommendations. They explore the role of B vitamins, epigenetics, and alternative tests. Topics include nitrous oxide exposure, folate metabolism, histidine supplementation, and optimizing health with data-driven decisions.
Understanding genetic variations impact methylation pathways and homocysteine metabolism.
Importance of personalized supplements based on genetic predispositions for optimal health.
Challenges the binary notion of over and under methylation, emphasizing individual enzymatic diversity.
Deep dives
Genetics Expert and Dirty Genes Author Discusses the State of the Genetic Industry
Dr. Ben Lynch, a genetics expert and author, delves into the current state of the genetic industry, highlighting the advancements in CRISPR technology and artificial intelligence applications in healthcare. He expresses concerns about overreliance on AI for research due to inaccuracies and highlights the need for human studies over animal ones.
Consumer Genetic Testing Companies and Fear-Based Information
Dr. Lynch critiques consumer genetic testing companies that exploit fear-based strategies, charging high prices for genetic information with limited beneficial recommendations. He emphasizes the importance of cautious supplement recommendations based on genetic variations, indicating that genetic data should be used in conjunction with lifestyle factors for a comprehensive approach.
MTHFR Gene Variation and Personal Experiences
The discussion shifts to the MTHFR gene variation and personal experiences shared by both individuals, focusing on the impact of methyl folate supplementation. Dr. Lynch and the host exchange insights on methylation processes, potential side effects of high methyl folate doses, and the importance of balancing methylation cycles with proper nutrients like histidine and niacin.
Analyzing Serum Biomarkers for Improved Health Outcomes
The conversation evolves into a deep dive on serum biomarkers and their role in optimizing health. Specific examples of tryptophan deficiencies and the impact on serotonin levels are explored, highlighting how individual variations in amino acid levels can influence overall well-being. The importance of personalized approaches and symptom monitoring alongside lab testing is emphasized throughout the discussion.
Concerns About Overmethylation and Homocysteine Levels
The discussion revolves around the concept of overmethylation and its correlation with homocysteine levels. The speaker questions the prevalence of low homocysteine levels in overmethylators, citing rare personal observations of such cases. The recommendation to address low homocysteine includes increasing protein intake and supplementing with glutathione to balance oxidative stress. The speaker dismisses the binary notion of over and under methylation, highlighting the diverse enzymatic activity across different tissues and organs.
Exploration of Nutrient Supplements and Physiology
The conversation delves into the speaker's personal supplement regimen and experimentation with various nutrients. Discussions range from the effects of acetyl glutathione to managing glutamate levels and addressing B vitamin deficiencies. Insights on proline, magnesium forms, testosterone levels, and desired biochemical outcomes are detailed. The talk emphasizes a data-driven and investigative approach to personal health optimization through targeted nutritional supplementation.
In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine.
Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes.
Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optimal levels.
They provide invaluable insights into personalized supplements tailored to address individual genetic predispositions and health needs.
Explore the latest advancements in methylation and homocysteine management, and discover actionable strategies for promoting longevity and optimal well being.
