The Proof with Simon Hill

Discover how the placement of body fat can influence your health and risk of metabolic disease. Learn about the critical role the liver plays in metabolic health and its connection to insulin resistance. Explore strategies for reducing harmful fat types and understand the significant impact of sleep on metabolism. Uncover effective tips to enhance metabolic well-being through lifestyle adjustments. Plus, delve into how stress and hormones contribute to metabolic challenges, and hear about evidence-based weight loss strategies.

Episode #339. Are you getting the full picture of your heart health? Learn why ApoB is the test you shouldn't skip. In this episode, I sit down with Dr Daniel Soffer, a preventive cardiologist and lipidologist, to break down the importance of ApoB testing for cardiovascular risk assessment.You'll learn why ApoB provides more comprehensive insights than LDL cholesterol alone, who can benefit most from this test, and how it fits into preventive cardiology. Dr Soffer shares practical advice for assessing cardiovascular disease risk, discusses the implications of diet and genetics on heart health, and explores case studies to help you understand when and why ApoB testing is crucial.Specifically, we discuss:  Introduction (00:00) Insight into Preventive Cardiology and Lipidology (01:38) Understanding Lipoproteins and Their Role in Cardiovascular Disease (06:40) Techniques for Lipoprotein Testing and Measurement (11:33) Exploring Atherosclerosis and Lipoprotein Retention Hypothesis (31:18) Epidemiological Changes in Health and Cardiovascular Profiles (55:06) Concerns about the Keto Diet and Elevated ApoB Levels (58:26) Approaches to Managing Elevated LDL Levels Clinically (01:01:13) The Role of Evidence-Based Medicine in Cardiovascular Guidelines (01:07:15) Comparing ApoB and LDL Cholesterol in Cardiovascular Risk (01:14:36) Understanding Discordance in Lipid Measurements (01:18:36) Advanced Imaging Techniques for Risk Assessment (01:25:50) Guidelines and Considerations for Statin Therapy (01:44:30) Coronary Artery Calcium Score, Stroke Risks, and Carotid Ultrasound (01:54:03) Dietary Interventions and Carotid Intima-Media Thickness (IMT) (01:59:22) Case Study: Family History’s Role in Cardiovascular Risk (02:05:05) Overview of Statins, PCSK9 Inhibitors, and Other Lipid-Lowering Therapies (02:12:24) Aspirin Therapy and Imaging in Cardiovascular Health (02:26:06) Setting Treatment Thresholds Based on ApoB Levels (02:39:57) Closing Thoughts on Cardiovascular Risk and ApoB (02:44:16) This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.MomentousMy go-to supplement brand for protein and creatine is Momentous. Use code LIVINGPROOF at checkout for 25% off and receive a free gift of 5 nights of their best-selling Sleep packs for orders over $75 at at livemomentous.com.Pique TeaPique’s Black Friday special is HERE. For a limited time, get a Chai tea FREE with your qualifying purchase at piquelife.com/simon. This is the only time you can get your hands on their Chai. Act fast; this limited-time offering is sure to sell out! The offer ends November 16th.Eight SleepUpgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF to get up to $600 off your Pod 4 Ultra purchase when bundled at eightsleep.com/theproof. This is their highest offer of the year! Try it risk-free for 30 days, with worldwide shipping.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and Facebook

Carter Gottlieb, a soon-to-be dermatologist renowned for his science-backed skincare insights, joins experienced yoga teacher Tawny Janae to discuss achieving optimal skin health. They dive into effective skincare routines, debunk common myths, and unpack the power of retinoids and niacinamide. The pair also emphasizes the crucial role of sunscreen in preventing damage and share tips on choosing the right moisturizers. With a blend of humor and expertise, they unravel the complexities of managing skin concerns from acne to aging.

Dr. Kellyann Niotis, the first fellowship-trained preventive neurologist, dives into the fascinating world of dementia prevention. She highlights that 45% of dementia cases are preventable by addressing 14 modifiable factors. From managing cholesterol and enhancing oral health to the surprising link between hearing loss and dementia risk, Dr. Niotis discusses effective lifestyle changes. She emphasizes mental health, exercise, and social connections as critical components for brain health, proving that it's never too late to start caring for our minds.

In this engaging conversation with Stephen Brooks, an ethnobotanist and permaculture advocate, the discussion revolves around the transformative power of sustainable living. Stephen shares insights on the ethics of modern food systems and highlights unique fruits to explore. He outlines practical permaculture practices that strengthen communities and emphasizes the importance of perennial crops. With tales from his journey across Costa Rica, he inspires listeners to reconnect with nature and envision a harmonious future where food systems heal the planet.

Episode #335. Struggling to keep weight off long term? Learn the science behind successful fat loss and maintenance with experts Kevin Maki, PhD, and Carol Kirkpatrick, PhD. In this episode, we discuss evidence-based strategies for losing body fat and keeping it off, while exploring the role of nutrition, exercise, and pharmacological interventions.You’ll learn about the impact of protein and fibre on hunger and satiety, the benefits of regular exercise for insulin sensitivity, and the potential role of medications like GLP-1 agonists. Dr Maki and Dr Kirkpatrick also share insights on the challenges of maintaining weight loss and how to make lasting changes for better health.Specifically, we discuss: Introductions (00:00) Carol’s Journey into Nutrition and Research Development (04:27) Kevin’s Path in Cardiometabolic Health Research (11:53) The Importance of Observational Studies in Nutrition (14:59) Understanding Dietary Fats and Cardiometabolic Health (19:49) Public Health Nutrition: Current Challenges and Opportunities (31:55) Exploring Obesity and Its Impact on Metabolic Health (43:19) How Exercise Enhances Insulin Sensitivity (53:35) The Link Between Insulin Resistance and Ectopic Fat (55:01) Weight Loss Challenges: Why It’s So Hard to Keep the Weight Off (01:01:05) How GLP-1 Agonists Are Transforming Obesity Treatment (01:04:02) Behavioural Aspects of Obesity: Understanding the Psychology (01:11:22) The 30-30-30 Study: A New Approach to Sustainable Weight Loss (01:24:44) Cholesterol, Fibre, and Cardiovascular Health (01:44:02) Protein Supplements and How They Affect Digestion (01:46:56) Dietary Patterns and Regulating Appetite for Better Health (01:49:23) Exploring the 30-30-30 Framework for Weight Loss (01:51:49) How Protein Sources Influence Metabolic Health (01:57:53) Carbohydrate Quality vs. Restriction: What Matters More? (02:14:57) Exercise for Weight Maintenance and Long-term Health (02:27:12) The Future of Nutrition Research and Public Health (02:30:25) Final Thoughts (02:35:10) Connect with Kevin Maki, PhD on LinkedIn and at https://www.mbclinicalresearch.com/. Connect with Carol Kirkpatrick, PhD on Twitter/X and LinkedIn.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions.MomentousMy go-to supplement brand for protein and creatine is Momentous. Get 20% off your first purchase by using the code LIVINGPROOF at checkout at livemomentous.comPique TeaStay energised without the coffee crash with Pique’s Sun Goddess Matcha. Organic, ceremonial-grade, and uniquely loaded with l-theanine to keep you calm and focused. Get up to 15% off plus a free beaker and frother at piquelife.com/simon.Eight SleepUpgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Venki Ramakrishnan, a Nobel Prize-winning structural biologist, dives into the fascinating science of aging. He explores why and how we age, highlighting the pivotal role of ribosomes in protein synthesis. Ramakrishnan addresses misleading anti-aging claims, the complex interplay of genetics, and the true meaning of 'biological age.' Listeners gain insights into practical strategies for slowing aging, the effects of lifestyle choices on longevity, and the promise of regenerative medicine. His engaging discussion challenges perceptions of aging and encourages a scientific approach to longevity.

Dr. Kellyann Niotis, a preventive neurologist, and Dr. Thomas Dayspring, a lipidologist, dive into the intriguing connection between cholesterol and dementia. They highlight vital preventive strategies for brain health, discussing the role of LDL cholesterol, genetic factors like the ApoE4 allele, and the significance of early lifestyle changes. With insights into personalized health strategies, they explore how managing cholesterol levels can be an effective way to reduce the risk of cognitive decline. Don't miss their tips on omega-3 fatty acids and new therapeutic approaches!

In this engaging discussion, lipidologist Dr. Thomas Dayspring and endocrinologist Dr. Karl Nadolsky delve into the intricacies of blood test results. They tackle cholesterol and cardiovascular health, highlighting the importance of different lipoproteins like ApoB. The conversation also unpacks the significance of testosterone levels and thyroid function in overall wellness. With a focus on understanding individual health metrics, they emphasize regular blood testing and lifestyle choices for optimal health.

Join leading scientists Dr. Bill Harris, Dr. Joel Fuhrman, Dr. Gary Fraser, Dr. Phillip Calder, and Dr. Kristina Harris as they dive deep into omega-3 and omega-6 fatty acids. Discover the crucial roles these fats play in brain health and inflammation. They debunk common myths about omega-6s and emphasize the importance of balancing omega intake. Explore how genetics and diet influence fatty acid metabolism, and learn about optimal supplementation for better health outcomes.