Immunology experts discuss immune memory to SARS-CoV-2 and COVID-19 vaccines, emphasizing CD8 T cells' role, different vaccine responses, epitope recognition, B cell longevity, booster efficacy debates, ethical obligations of billionaires, and the importance of knowledge sharing for vaccine development.

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Jonathan C. Kagan Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Approaching the asymptote (Cold Spring Harb Symp Quant Biol) Infection infidelities drive innate immunity (Science) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immunology experts Cindy, Steph, Brianne, and Vincent review diverse papers on immune system wiring, streptococcus vaccines, SARS-CoV-2 mRNA vaccination's IgG4 switch, B cell insights, unique antibodies against streptococcus, impact of SARS-CoV-2 exposure on immunity, and diverse immune responses from continuous germinal center invasion.

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CAR T for SLE (Nat MEd) Maternal gut microbiome induced IgG (Sci Immunol) Long-primed germinal centers (Nature) Fc mediated protection against SARS-CoV-2 VOC (bioRxiv) Dark side of macrophages (Nat Med) Pregnancy and antibody protection against infection (Nature) Regulators of inflammatory response to mRNA vaccines (Nature Immunol) Antibody effector function and protection against RSV (Cell) Color coded antibodies (bioRxiv) Endogenous retroviruses and inflammation (Cell) CD8 T cells and vaccine protection against SARS-CoV-2 (Sci Immunol) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

De’Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guests D’Broski Herbert Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Immunology of helminth infections (Ann Rev Immunology) Neuroimmune regulatory networks (J Leuk Biol) Every cell is an immune cell (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

From SLB22 on the Island of Hawai’i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guests: Julia Bohannon and Musa Mhlanga Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode From the ashes (Richmond Register) Innate immune memory (J Immunol) Epigenetics and metabolism in trained immunity (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Somali and Phil join Immune to discuss their approaches to immunology education. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Sumali Pandey and Phil Mixter Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode ImmunoReach ASMCUE: ASM Conference for Undergraduate Educators (ASMCUE) Upcoming ASM Webinars: free Microedu Live! discussions: Friday, October 14, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be the assessment of learning. Register here. Friday, November 4, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be microbiology laboratory biosafety. Register here. Journals with relevant education resources: AAI ImmunoHorizons ImmunoHorizons Journal of Microbiology and Biology Education (ASM; open-source, see Tips & Tools for examples):Journal of Microbiology & Biology Education Table of Contents Volume 23, Issue 2 (asm.org) CBE Life Sciences Education CBE–Life Sciences Education (LSE) (lifescied.org)  How to tell your professional story effectively – for instruction-focused scientists (including external review): Initiative: External Peer Review of Teaching – The Teaching Academy of the Consortium of West Region Colleges of Veterinary Medicine (westregioncvm.org)  ASM Carski Award for Educators: ASM Carski Award for Undergraduate Education Undergraduate degree program in Immunology at University of Alabama-Birmingham (only one in the USA): CAS – Undergraduate Immunology Program | UAB 3D printable antibody-antigen epitope models Antibody Epitope teaching kit by esuchman – Thingiverse Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be ‘good’ or ‘bad’ in their function. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Mandy McGeachy Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Th17 cytokines in health and disease (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Gut B cell dysbiosis in ulcerative colitis (Nat Med) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Bacteria induce skin regeneration via IL-1beta (Cell Host Microbe) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv