Immune

Exploring hyper vaccination with 217 COVID doses, modifying antigens for immune response suppression, gut bacteria promoting tolerance in neonates, immune responses to SARS-CoV-2 challenge, and ethical concerns in vaccine testing.

Exploring how neutrophils combat bacteria by squeezing through endothelial cells, enhancing killing mechanisms without increased phagocytosis. Discussion on cellular force measurement techniques, Knox proteins' impact on ROS production, and the influence of mechanical force on neutrophil movement.

Juliet Morrison discusses pleural macrophages translocating to the lungs during infection to enhance influenza outcomes. They explore the importance of macrophages in viral infections, diversity in graduate applications, macrophage migration, Dengue vaccine feasibility, and navigating disease topics on social media.

Ang Cui discusses her career and work on the Immune Dictionary, a compendium of single-cell transcriptomic profiles of immune cell types in response to cytokines in mouse lymph nodes. The podcast covers topics such as the process of submitting and reviewing scientific papers, creating figures for the paper, mapping cell responses to cytokines, comparing mouse and human immune systems, and future research plans.

Carla Nowosad, a researcher in germinal center dynamics and B cell immunology, discusses her work on germinal centers, including their unique synapses and antigen movement. She also explores the role of germinal centers in gut antibody production and their interaction with the microbiome. The podcast covers techniques and challenges of single cell sequencing, germinal center selection, and antibody generation. Additionally, Carla offers valuable advice for graduate students and early career scientists.

The podcast explores the total mass and number of immune cells in the human body, as well as the size and weight of organs. It discusses the differences in immune cell density between blood and organs, and analyzes the distribution and abundance of immune cells. The hosts also discuss the potential influence of Duplimumab on COVID-19 severity and delve into the role of mast cells and allergies.

Ellen Rothenberg, a scientist known for her work on retroviruses and T-cell development, discusses her career in science. Topics include her upbringing, social changes at Harvard in the 1970s, choosing science over art, interest in virology, understanding T cell development, unpredictable nature of scientific discoveries, challenges in basic science research in immunology, and gratitude for support and science communication.

Expert in parasitic worms and their impact on viral infections discusses how exposure to lung-migrating helminths in a mouse model protects against SARS-CoV-2 infection. Topics include helmet infections and lower mortality rates of COVID-19, the immune response to SARS-CoV-2 in mice with parasite infection, the role of macrophages and CD4 T cells in the lung immunological environment, the complex relationship between parasitic infections, macrophage response, and SARS-CoV-2, manipulating the microenvironment using parasites, TH2 cytokines and their role in diseases and vaccines, and the polarizing dislike of cilantro.

Delving into the immunology of picky eating, the podcast explores how mast cells, IgE antibodies, and the brain collaborate to trigger avoidance of certain foods to prevent allergic reactions. It discusses the intricate connections between immune responses and behavior, as well as the role of B cells, histamine release, and genetic studies in understanding picky eating behaviors.

Kevin Ng, a researcher studying the promotion of immunotherapy of lung cancer by antibodies against endogenous retroviruses, joins Immune and discusses his work. They explore the role of endogenous retroviruses in the immune system and the development of a mouse model for studying lung cancer. They also delve into the functionality of B cells in tumor protection, the role of PD1 and PDL1 in regulating the immune response, and using gene sequencing and baseline data to predict cancer response.