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Immune
Immune 75: Ang Cui unveils the cytokine symphony
Dec 28, 2023
Ang Cui discusses her career and work on the Immune Dictionary, a compendium of single-cell transcriptomic profiles of immune cell types in response to cytokines in mouse lymph nodes. The podcast covers topics such as the process of submitting and reviewing scientific papers, creating figures for the paper, mapping cell responses to cytokines, comparing mouse and human immune systems, and future research plans.
01:15:03
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Quick takeaways
- The Immune Dictionary provides a comprehensive map of how different immune cells respond to specific cytokines, giving insights into immune cell behavior that was previously unknown.
- The immune dictionary offers a valuable resource for researchers to explore immune cell behavior, investigate combinatorial effects of cytokines, and inform therapeutic strategies.
Deep dives
Development of the Immune Dictionary
The podcast episode discusses the development of an immune dictionary that maps the responses of different immune cells to 86 cytokines at a single-cell resolution. The dictionary was created through an ambitious project involving the injection of individual cytokines into mice, followed by single-cell sequencing of lymph nodes to analyze the gene expression changes. The aim was to understand how different cell types respond to specific cytokines, providing valuable insights into immune cell behavior that had not been characterized before.
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Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode