Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Al Singer Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode T cell FlipFlop mice reveal lineage determination (Nat Immunol) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode KIR+CD8+ regulatory T cells (Science) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Age-dependent reduction in asthmatic pathology (J Immune) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Trogocytosis in Immune 18 B cells steal from dendritic cells (Science) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Gabriel Victora Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Concerto in B (TWiV 161) Visualizing antibody affinity maturation (Science) Restricted B cell clonality after boosting (Cell) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Nikhil Joshi Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Creation of NINJA mice (Nature Biotech) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode DNA binding to TLR9 on red blood cells (Sci Transl Med) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Keke Fairfax Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Maternal schistosomiasis impairs offspring immunity (PloS Path) Helminth modulation of macrophage immunometabolism (Immune) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Timothy Hand Click arrow to play Download Immune 48 (43 MB .mp3, 71 min) Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Mouse model for EED (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Antiviral IgA potentiates NETosis (PNAS) Letters read on Immune 47 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv