Immune

Ellen Rothenberg, a scientist known for her work on retroviruses and T-cell development, discusses her career in science. Topics include her upbringing, social changes at Harvard in the 1970s, choosing science over art, interest in virology, understanding T cell development, unpredictable nature of scientific discoveries, challenges in basic science research in immunology, and gratitude for support and science communication.

Expert in parasitic worms and their impact on viral infections discusses how exposure to lung-migrating helminths in a mouse model protects against SARS-CoV-2 infection. Topics include helmet infections and lower mortality rates of COVID-19, the immune response to SARS-CoV-2 in mice with parasite infection, the role of macrophages and CD4 T cells in the lung immunological environment, the complex relationship between parasitic infections, macrophage response, and SARS-CoV-2, manipulating the microenvironment using parasites, TH2 cytokines and their role in diseases and vaccines, and the polarizing dislike of cilantro.

Delving into the immunology of picky eating, the podcast explores how mast cells, IgE antibodies, and the brain collaborate to trigger avoidance of certain foods to prevent allergic reactions. It discusses the intricate connections between immune responses and behavior, as well as the role of B cells, histamine release, and genetic studies in understanding picky eating behaviors.

Kevin Ng, a researcher studying the promotion of immunotherapy of lung cancer by antibodies against endogenous retroviruses, joins Immune and discusses his work. They explore the role of endogenous retroviruses in the immune system and the development of a mouse model for studying lung cancer. They also delve into the functionality of B cells in tumor protection, the role of PD1 and PDL1 in regulating the immune response, and using gene sequencing and baseline data to predict cancer response.

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel Download Immune 66 (45 MB .mp3, 76 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immunological imprinting (Immunity) COVID-19 vaccine imprinting (bioRxiv) Original antigenic sin (J Inf Dis) Are competition (LJII) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Podcast discusses the longevity and division capabilities of T cells in mice over 10 years and 51 immunizations. Topics include memory T cell responses, telomere activity, cell transfers in cancer, and advancements in cell research. Conversations also cover hypogammaglobulinemia, ME-CFS, wound healing benefits, and open-access papers on Lupus, virology, and neuroton in immune responses.

Immunology experts discuss immune memory to SARS-CoV-2 and COVID-19 vaccines, emphasizing CD8 T cells' role, different vaccine responses, epitope recognition, B cell longevity, booster efficacy debates, ethical obligations of billionaires, and the importance of knowledge sharing for vaccine development.

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Jonathan C. Kagan Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Approaching the asymptote (Cold Spring Harb Symp Quant Biol) Infection infidelities drive innate immunity (Science) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immunology experts Cindy, Steph, Brianne, and Vincent review diverse papers on immune system wiring, streptococcus vaccines, SARS-CoV-2 mRNA vaccination's IgG4 switch, B cell insights, unique antibodies against streptococcus, impact of SARS-CoV-2 exposure on immunity, and diverse immune responses from continuous germinal center invasion.

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CAR T for SLE (Nat MEd) Maternal gut microbiome induced IgG (Sci Immunol) Long-primed germinal centers (Nature) Fc mediated protection against SARS-CoV-2 VOC (bioRxiv) Dark side of macrophages (Nat Med) Pregnancy and antibody protection against infection (Nature) Regulators of inflammatory response to mRNA vaccines (Nature Immunol) Antibody effector function and protection against RSV (Cell) Color coded antibodies (bioRxiv) Endogenous retroviruses and inflammation (Cell) CD8 T cells and vaccine protection against SARS-CoV-2 (Sci Immunol) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv