Immune
Immune 76: Macrophages to the rescue with Juliet Morrison
Jan 30, 2024
Juliet Morrison discusses pleural macrophages translocating to the lungs during infection to enhance influenza outcomes. They explore the importance of macrophages in viral infections, diversity in graduate applications, macrophage migration, Dengue vaccine feasibility, and navigating disease topics on social media.
01:07:07
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Quick takeaways
- Pleural macrophages are crucial in improving influenza outcomes by modulating inflammatory responses.
- Transcriptomic analysis shows variations in cytokine profiles and immune responses to different influenza strains.
Deep dives
Plural Macrophages and Inflammation Response
Plural macrophages play a crucial role in responding to influenza infection in the lung. Depletion experiments using clodronate liposomes showed that when the plural macrophages were eliminated, the severity of the disease increased, indicating their essential role in modulating inflammatory responses and improving disease outcomes.
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