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- Development of effective RSV vaccine for older individuals using adjuvanted purified protein F.
- Importance of understanding RSV replication to predict antigenic variants and vaccine-induced immune pressure.
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RSV Vaccine Development
The respiratory syncytial virus (RSV) vaccine has historically been challenging to develop due to past issues with vaccine-induced worsened disease outcomes. Recent advances in understanding the structural basis of RSV led to the development of a vaccine that showed significant protection in a phase 3 trial for individuals over 65, reducing the risk of severe RSV-associated lower respiratory tract disease by 94.1%. The vaccine uses an adjuvanted purified protein F from the virus, and the package insert specifies that it's safe for individuals with latex allergies.
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Listen to the best highlights from the podcasts you love and dive into the full episode