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Immune
Immune 77: Squeezing the most killing out of neutrophils
Feb 27, 2024
Exploring how neutrophils combat bacteria by squeezing through endothelial cells, enhancing killing mechanisms without increased phagocytosis. Discussion on cellular force measurement techniques, Knox proteins' impact on ROS production, and the influence of mechanical force on neutrophil movement.
56:58
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- Neutrophils activate bactericidal function by squeezing through endothelial cells via mechanosensing.
- Multilobular nuclei help neutrophils squeeze through narrow spaces for transendothelial migration.
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Transendothelial Migration Activates Neutrophil Bactericidal Function
Neutrophils need to exit the blood to enter tissues for bacterial-killing. The process of transendothelial migration squishes the neutrophils, activating their antibacterial program, as revealed by a study on the activation of bactericidal function via PZO1 mechanosensing.
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Discover
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