Immune

Immune 77: Squeezing the most killing out of neutrophils

Feb 27, 2024

Exploring how neutrophils combat bacteria by squeezing through endothelial cells, enhancing killing mechanisms without increased phagocytosis. Discussion on cellular force measurement techniques, Knox proteins' impact on ROS production, and the influence of mechanical force on neutrophil movement.

56:58

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Quick takeaways

Neutrophils activate bactericidal function by squeezing through endothelial cells via mechanosensing.

Multilobular nuclei help neutrophils squeeze through narrow spaces for transendothelial migration.

Neutrophils utilize phagocytosis, NETs, and ROS production as key antibacterial mechanisms.

Deep dives

Transendothelial Migration Activates Neutrophil Bactericidal Function

Neutrophils need to exit the blood to enter tissues for bacterial-killing. The process of transendothelial migration squishes the neutrophils, activating their antibacterial program, as revealed by a study on the activation of bactericidal function via PZO1 mechanosensing.

Introduction

4min

Exploring Neutrophil Functions and Migration

15min

Exploring Cellular Force and Migration through Innovative Techniques and Model Organisms

6min

Enhanced Neutrophil Antibacterial Killing Mechanisms

14min

Exploring the Influence of Mechanical Force and Signaling on Neutrophil Movement

3min

Knox Proteins and Neutrophil Response to Squeezing

12min

Exploring Cell Migration and Function Dynamics

3min

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

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Trans endothelial migration activates neutrophil killing (Immunity)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

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Immune

Immune 77: Squeezing the most killing out of neutrophils

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

Transendothelial Migration Activates Neutrophil Bactericidal Function

Neutrophil Nucleus Structure Facilitates Transmigration

Neutrophil Recruitment and Shear Stress in Inflammatory Responses

Neutrophil Functions: Phagocytosis, Degranulation, and NETs

The Role of PZO1 and Knox4 in Neutrophil Function

Remember Everything You Learn from Podcasts