Immune 81: T cells and tolerance with Joseph Larkin III
Jun 25, 2024
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Researcher Joseph Larkin III discusses T cell subsets in maintaining tolerance. Topics include regulatory T cells in autoimmune diseases, COVID antibodies in breast milk, and promoting diversity in research for children's health.
Dr. Larkin's research focuses on T cell subsets maintaining tolerance.
His work highlights breast milk's transfer of protective antibodies to infants.
Deep dives
Dr. Joseph Larkin's Science Enthusiasm
Dr. Joseph Larkin from the University of Florida shares his childhood inspiration for science, sparked by a TV program highlighting kids in need of medical attention. This emotional moment led him to develop a passion for helping others, shaping his interest in science and research.
Transition to Research and Graduate Studies
Initially pre-med, Dr. Larkin's journey into research was catalyzed by an inspiring chemistry professor at the University of Florida. Engaging in undergraduate research on signal transduction and interferon gamma signaling propelled his fascination with being the sole source of unique knowledge during experiments.
PhD Research at the University of Pennsylvania
Continuing his scientific pursuits at the University of Pennsylvania, Dr. Larkin delved into studying regulatory T cells with a focus on thymic development and interactions in mouse models. His exploration led to significant findings on signal transduction regulation and the role of regulatory T cells in autoimmune diseases like lupus.
Breast Milk Research and Diversity Advocacy
Expanding his research to breast milk's transfer of SARS-CoV-specific antibodies, Dr. Larkin's work showcased protective IgA and IgG transfer to infants through breastfeeding. Beyond research, his commitment to diversity and mentorship, seen through promoting underrepresented student success and advocating for inclusivity, emphasizes the importance of varied perspectives in scientific advancement.
Immune travels to Chicago for the American Association of Immunologists conference where they meet up with Joseph Larkin III to talk about his career and his research on the contribution of T lymphocyte subsets and functions in maintaining tolerance.