My guest is Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and clinical assistant professor of integrative medicine & nutritional sciences at Thomas Jefferson University. Dr. Gottfried specializes in hormone health, vitality and longevity using precision/personalized approaches. We discuss female hormone health, puberty, perimenopause, and menopause, hormone testing, the microbiome, stress related hormone challenges, their causes, and various treatments. We also discuss fertility, birth control and tools for improving microbiome health, treating PCOS, insulin management, and the best nutrition, supplementation, and exercise programs for women. While the episode focuses mainly on female hormones, males will also  benefit from our discussion because it includes  actionable tools suggested for managing stress, bolstering the gut microbiome, and immunity—all of which stand to improve overall health, vitality and longevity in males and females.For the full show notes, visit hubermanlab.com.Thank you to our sponsorsAG1: https://athleticgreens.com/hubermanLMNT: https://drinklmnt.com/hubermanSupplements from Momentoushttps://www.livemomentous.com/hubermanTimestamps(00:00:00) Dr. Sara Gottfried(00:04:07) Sponsor: LMNT(00:07:50) Women, Family History, Heredity & Environment(00:11:00) Puberty, Stress, Menstrual Cycles, Intrauterine Devices (IUDs)(00:17:26) Tool: Sex Hormones, Microbiome, Estrobolome & Disease; Biomarker Testing(00:25:11) Nutritional Testing; Vegetables, Microbiome & Disease(00:27:33) Sponsor: AG1(00:32:22) Microbiome, Prebiotics & Probiotics, Inflammation(00:36:08) Microbiome Testing, Magnesium, Constipation & Thyroid(00:42:25) Female Colonoscopy; Network Effect & Modern Medicine, Stress Factors(00:45:13) Constipation, Stress & Trauma, Autonomic Balance(00:55:35) Constipation Relief, Stress, Breathwork & Meditation(01:02:58) Systemic & Societal Stress Unique to Females(01:09:23) Testing & Future Behavior(01:11:55) Polycystic Ovary Syndrome (PCOS) & Cardiometabolic Disease; Stress (01:22:57) PCOS, Insulin, Glucose Monitoring and Management; Data Access(01:29:48) Behaviors for Vitality; Exercise & Body Phenotype; Cortisol(01:36:40) Cortisol Supplements: Ashwagandha, Rhodiola, Fish Oil, Phosphatidylserine(01:42:36) Cortisol, Anxiety & Immune System; Adrenal Function, Resilience(01:48:07) Tool: Omega-3 Fatty Acids, Inflammation, Specialized Pro-Resolving Mediators(01:54:20) Oral Contraceptives, Benefits & Risks; Ovarian Cancer; Testosterone(02:06:50) Fertility, Follicular & Anti-Mullerian Hormone (AMH) Assessments(02:10:29) Menopause & Hormone Replacement Therapy; Women’s Health Initiative(02:15:30) Perimenopause, Cerebral Hypometabolism, Metabolism & Estrogen(02:21:49) Intermittent Fasting, Ketogenic Diet, Metabolic Flexibility (02:23:29) Stool Testing(02:25:32) Coronary Artery Calcium (CAC) Test, ACE Score & Disease (02:31:56) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Neural Network Newsletter, MomentousTitle Card Photo Credit: Mike BlabacDisclaimer

Dr. Sara Gottfried, an expert in women's health, discusses the hormonal changes women face after 40, including weight redistribution, insulin resistance, and cortisol imbalances. She explores the dissatisfaction with conventional medical approaches to perimenopause symptoms, emphasizes the importance of hormone balance, and offers practical tips for optimizing hormones through diet and lifestyle interventions. The podcast also covers the impact of stress on sleep, the interplay between cortisol and thyroid hormones, and the need for a holistic approach to women's health.

Discover the importance of muscle mass for metabolic health and longevity. Learn about the benefits of strength training and protein intake in building skeletal muscle. Explore the impact of muscle on insulin levels, glucose disposal, and overall well-being.

Dr. Sara Gottfried discusses the rise in autoimmunity linked to trauma, early warning signs of autoimmune diseases, non-toxic living, factors influencing autoimmunity, trauma resolution, psychedelics in healing, stress impact on autoimmunity, wearables for health optimization, and strength training benefits for autoimmune individuals.

Dr. Sara Gottfried discusses the impact of stress and trauma on autoimmune diseases. She highlights how unresolved trauma can lead to chronic illnesses and shares signs of the body attacking itself. The importance of healing in the parasympathetic state and strategies for addressing autoimmune symptoms through nutrition, stress management, and healing trauma are explored.

Dr. Sara Gottfried, a Harvard-educated physician, discusses PCOS, a leading cause of infertility. She explains the origins and available treatments for PCOS. Topics covered include diagnosis, the role of testosterone, and four lifestyle changes. The podcast also introduces InsideTracker, a personalized health plan, and explores the connection between low testosterone and high estrogen levels in PCOS.

Dr. Sara Gottfried discusses hormonal changes during perimenopause and menopause, stress impact, immune system changes, and metabolic shifts. Topics include mitochondrial function, hormone therapy, PCOS, and postpartum depression. Key takeaways cover symptom management, mitochondrial function monitoring, strategies for PCOS, and addressing postpartum depression.

Explore the underlying causes of autoimmune diseases with Dr. Sara Gottfried as she uncovers the correlation between trauma and autoimmune conditions. Learn about the impact of lifestyle, genetics, and environment on autoimmune disorders. Dive into the connection between gut health, microbiome, and autoimmune diseases like celiac and Hashimoto's. Discover the role of brain metabolism, neurology, and immune system complexities in autoimmune conditions. Embrace self-empowerment and love in making health choices.

Dr. Sara Gottfried, expert in women's health, discusses hormone imbalances, autoimmune diseases, challenges of PCOS and fertility, progesterone optimization, and managing stress. She emphasizes symptom-guided hormone health, the necessity of comprehensive testing, and the rise in autoimmunity among women.

Dr. Sara Gottfried, pioneer in health, research, and education, discusses topics from her new book. They cover the importance of metabolic health, tracking glucose levels, the impact of a ketogenic diet on women, hormones in women's metabolic health, democratizing access to metabolic health data, the predictive ability of glucose levels for type two diabetes risk, and collaboration and empowerment.