Huberman Lab Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health
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Feb 19, 2024 
Dr. Mark D'Esposito, a neurologist and professor at UC Berkeley, shares insights on optimizing cognitive function and brain health. He discusses the intricate roles of dopamine and acetylcholine in enhancing memory and focus. The conversation delves into the effects of traumatic brain injury and strategies to mitigate cognitive decline through lifestyle changes. Additionally, he explores the impact of smartphones on attention and the importance of neuroplasticity for recovery and cognitive enhancement, emphasizing the synergy of exercise and mindfulness in brain health.
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Prefrontal Cortex Role
- The prefrontal cortex, the highest level of cortex, is crucial for planning, organizing, and goal-directed actions.
- It's the "CEO" or "conductor," controlling the rest of the brain and enabling cognitive control.
Frontal Lobe Vulnerabilities
- Frontal lobe vulnerabilities manifest during sleep deprivation, stress, and aging, affecting prioritization, goal achievement, and adaptability.
- Subtle signs include distraction, difficulty adapting, and struggles with achieving set goals.
Frontal Lobe Development
- Frontal lobe development extends into the early twenties, allowing for exploration and flexible problem-solving.
- This slow maturation allows us to explore and develop flexible behavior, but can also cause difficulties.