#116 - AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
Jun 22, 2020
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Dom D’Agostino, an Associate Professor at the University of South Florida and an expert in ketosis research, discusses the ins and outs of the ketogenic diet. He gives practical tips on optimizing health through training, supplements, and intermittent fasting. The conversation explores how genetic factors influence responses to ketogenic diets and examines the long-term effects on thyroid function. With intriguing insights on measuring ketones and the diet's impact on appetite control, D'Agostino delivers a comprehensive look at this popular health trend.
Ketogenic diet beneficial for appetite control and weight management.
Implications of long-term genetic adaptations to ketogenic diet discussed by Dom D’Agostino.
Deep dives
Two-Part Series with Dom D'Agostino
This podcast episode highlights a special two-part series featuring Dom D'Agostino, a renowned neurobiologist known for his expertise on ketogenic diets and ketosis. Originally scheduled for an interview with the host, Peter Attia, Bob Caplin stepped in to conduct a comprehensive Q&A session with Dom. This episode delves into various questions on ketogenic diets, ketosis, and their impact on different forms of exercise, offering valuable insights into this subject.
Practical Applications of Ketosis Research
Dom D'Agostino discusses the practical applications of his lab's research on ketosis in human scenarios. From collaborations with NASA on extreme environment missions to studying cancer cachexia and genetic diseases, Dom's team explores the effects of ketone metabolic therapies. They aim to influence not only metabolic perspectives but also target epigenetic pathways for disease treatment. Dom emphasizes the importance of baseline data collection for future research, demonstrating a multifaceted approach to utilizing ketosis in varied health contexts.
Quantifying and Utilization of Ketones
The discussion shifts towards quantifying and understanding the utilization of ketones, particularly through various measurement devices like blood, breath, and urine tests. Dom elaborates on the efficiency of breath acetone meters in assessing fat oxidation, especially in clinical settings like epilepsy management. A detailed comparison of different devices' readings provides insights into metabolizing ketones efficiently and the implications for optimizing health benefits through strategic utilization of ketosis.
Back by very popular demand for a special AMA episode, ketosis expert Dom D’Agostino joins Bob Kaplan, Peter’s Head of Research, to address many lingering questions about the ketogenic diet, exogenous ketones, and exercise for overall health. Dom also shares valuable insights from his personal experience with training, supplements, intermittent fasting, and other nutritional strategies to optimize his own health and performance. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on the website show notes page.
We discuss:
Dom’s recent and ongoing projects [3:00];
Benefits of a ketogenic diet for an otherwise healthy person [7:00];
Book recommendations to become more knowledgeable about a ketogenic diet [11:30];
Best devices for measuring ketones [13:45];
Genetic factors that influence how someone responds to the ketogenic diet [24:45];
Ketogenic diet for those with the APOE e4 allele [28:15];
Impact of long-term ketogenic diets on thyroid function [34:25];
Low-carb and ketogenic diets for appetite control and weight management [39:00];
Ketogenic diet and the microbiome [43:00];
Comparing monounsaturated fat versus saturated fat on the ketogenic diet [45:55];
Implications of long-term genetic and epigenetic adaptations to a ketogenic diet [47:45];
Why some people see a rise in LDL-C and LDL-P when on a ketogenic diet and what they can do about it [50:15];
Should someone with familial hypercholesterolemia consider a ketogenic diet? [55:00];
Exogenous ketones—benefits, therapeutic uses, and ketone supplements that Dom has tested [56:45];
Ketogenic protocols for management of traumatic brain injuries [1:06:00];
Comparing the benefits and therapeutic uses of various medium-chain fatty acids—caprylic acid (C8), capric acid (C10), MCT oil, and coconut oil [1:08:45];
Nootropics, caffeine, and other stimulants [1:16:15];
Supplemental use of testosterone, DHEA, and creatine for muscle growth and performance [1:23:45];
Impact of fasted-state training on strength and performance [1:30:15];
Stacking exogenous ketones with MCTs for optimal effectiveness [1:33:30];
BCAA supplements during a fast for muscle preservation [1:35:45];
What app is Dom using to track his macros? [1:42:00];
Getting enough micronutrients while on a ketogenic diet [1:47:15];
Ideal macros and getting enough protein for strength training in ketosis [1:48:15];
Pros, cons, and ideal macros of one meal a day [1:51:15];
Dom’s take on “carb backloading” [1:54:45];
Dom’s take on “carb up” days for ketogenic dieters [2:01:00];
Dom’s thoughts on the carnivore diet and the paleolithic ketogenic diet [2:05:30];
Advantages of the ketogenic diet for extreme endurance athletes [2:10:30];
Impact on strength, power, and performance during the adaptation period of the ketogenic diet [2:14:00];
Fasted-state elevation in growth hormone and its impact on training [2:17:45];
Is it possible to build muscle on a ketogenic diet? [2:23:30];
Why Dom took a year off from weight training [2:28:00];
What does Dom do for cardio exercise? [2:30:45];
Protocols for hard training recovery [2:33:15];
Dom’s personal approach to fasting, time-restricted eating, and sleep [2:35:45];
People, books, and other resources that shaped Dom’s training and nutrition [2:38:45]; and