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Fast Talk

281: Nerd Lab: How Dr. George Brooks Revolutionized our Understanding of Lactate

Aug 17, 2023
Dr. George Brooks revolutionized our understanding of lactate and health. Discover his groundbreaking research challenging the misconception of lactate as a waste product. Explore the significance of lactate in cancer survival, managing heat, hydration, and fueling for performance. Learn about the history and misconceptions of lactate and the lactate shuttle hypothesis. Understand the role of lactate in cancer, its effects on cancer cells and the immune system, and its importance in exercise and metabolic flexibility.
01:11:17

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Podcast summary created with Snipd AI

Quick takeaways

  • Lactate is not a waste product but a critical fuel for the body, challenging the common understanding of its role in fatigue.
  • Trained athletes have better lactate clearance abilities, highlighting the importance of lactate clearance in maintaining energy levels during exercise and enhancing athletic performance.

Deep dives

Lactate: A Critical Fuel for the Body

Lactate, once thought to be a waste product that causes fatigue, is actually a critical fuel for the body. This is the main idea presented in the podcast episode. In the 1980s, Dr. George Brooks challenged the common understanding of lactate and proposed the lactate shuttle theory. He found that lactate is not produced excessively during exercise, but rather trained athletes are better at clearing it. In a later review, Dr. Brooks explained how lactate serves as a source of fuel, shuttling between cells and tissues. Interestingly, the episode also explored Dr. Brooks' research on the role of lactate in cancer metabolism. It was suggested that lactate plays a crucial role in cancer survival and growth. Overall, the episode highlights the complexity and importance of lactate as a fuel and its relevance in both athletic performance and cancer research.

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