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281: Nerd Lab: How Dr. George Brooks Revolutionized our Understanding of Lactate

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The Role of Lactate in Cancer Pathogenesis

This chapter discusses the process of increased glucose uptake within a cell, leading to upregulation of glycolytic enzymes and decreased mitochondrial activity. It explains how the downregulation of mitochondria prevents the use of lactate as fuel and leads to its accumulation, with implications for cancer and metabolism.

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