Neuroscientist Dr. Lisa Mosconi On Menopause, Hormone Health, & Alzheimer’s Prevention
Mar 11, 2024
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Dr. Lisa Mosconi, a leading neuroscientist in women's health, dives into the significant neurological impacts of menopause. She highlights its role as a neuroendocrine transition and discusses its connections to Alzheimer's prevention. Dr. Mosconi emphasizes the importance of nutrition, lifestyle choices, and hormone replacement therapy on women's brain health. She also addresses the emotional complexities of genetic testing, the effects of cardiovascular health, and the need to challenge outdated perceptions around menopause, advocating for increased awareness in women's health.
Menopause reshapes the brain's metabolic activity post-menopause, impacting cognitive functions and energy levels.
Menopause offers positive benefits like enhanced empathy, increased contentment, and liberation from societal norms.
Alzheimer's is characterized by specific brain changes, affecting memory, attention, language, and daily tasks.
Hormonal fluctuations in menopause can contribute to cognitive decline and increase Alzheimer's risk.
Studies should focus on tracking brain changes in diverse menopausal experiences and exploring hormone replacement therapy options.
Exercise, particularly moderate aerobic activities like hiking, stimulates brain blood flow and supports cognitive health.
Deep dives
Menopause and Brain Changes
Menopause triggers significant changes in the brain's metabolic activity, affecting brain energy levels and cognitive functions. Brain scans show a 20-30% reduction in glucose metabolism post-menopause, leading to symptoms like brain fog, memory issues, and mood changes. These alterations validate women's experiences of cognitive shifts during menopause and emphasize the need for understanding and support during this transitional phase.
Evolutionary Benefits of Menopause
Menopause, often viewed as an anomaly in evolutionary terms, is now understood as a crucial stage for women's survival and thriving. The Grandmother Hypothesis posits that menopause allows women to shift from reproduction to caregiving roles, promoting the survival of offspring and enhancing empathy. Brain changes post-menopause may lead to increased life contentment, enhanced empathy, and a sense of liberation from societal norms, underscoring menopause's positive impacts on women.
Alzheimer's and Dementia Differentiation
Alzheimer's is a specific form of dementia characterized by the presence of amyloid-beta plaques and neurofibrillary tangles in the brain. It primarily affects memory, attention, language, and daily living tasks. Dementia, on the other hand, is a broad term encompassing various cognitive disorders with Alzheimer's being the most common type. The distinction lies in the specific pathological changes observed in the brain.
Impact of Hormonal Changes on Brain Health
Hormonal fluctuations during menopause can contribute to cognitive decline and increase the risk of neurodegenerative disorders like Alzheimer's disease. Surgical menopause, induced by hysterectomy, poses higher risks for cognitive changes post-menopause. Understanding the role of hormones in brain health and exploring hormone replacement therapy options could help mitigate cognitive decline and promote brain resilience.
Research Urgencies in Menopausal Brain Changes
Future studies should focus on tracking women's brain changes during different menopausal transitions, exploring the impacts of diverse menopausal experiences, such as surgical and medically induced menopause, on brain health. Additionally, investigating the effects of hormone replacement therapy post-menopause and examining genetic predispositions for Alzheimer's could provide critical insights into enhancing brain health during menopause.
Challenges in Menopausal Care
Addressing the varied experiences of menopausal women, including those undergoing surgical or medically induced menopause, requires a comprehensive approach to care. Recognizing the impacts of different menopausal pathways on cognitive health and emotional well-being is vital for providing tailored support and interventions to alleviate symptoms and promote brain resilience during menopause.
Impact of Hormone Replacement Therapy on Dementia Risk
Starting hormone replacement therapy with estrogen only within 10 years of menopause onset can reduce dementia risk by about 32%, as supported by a large meta-analysis study. However, starting estrogen and synthetic progesterone early in menopause is linked with a significant risk reduction of about 23% for dementia. For those more than 10 years after menopause, the data is more variable, with estrogen alone showing a neutral effect and estrogen with synthetic progesterone possibly increasing risk.
The Role of Exercise in Brain Health
Exercise, particularly moderate intensity aerobic exercise like hiking, has been found to stimulate blood flow to the brain, supporting cognitive health. Different forms of exercise, including strength training and mind-body techniques like yoga, can improve mood, reduce depressive symptoms, and enhance metabolic resilience, essential for brain health. Consistency and sustainability in physical activity, tailored to individual preferences, are emphasized for long-term brain benefits.
Designer Estrogen Fido-sarm for Brain Health
Fido-sarm, a plant-derived selective estrogen receptor modulator, has been designed to target the beta estrogen receptors in the brain while minimizing effects on reproductive tissues, reducing the risk of breast cancer. This specialized estrogen is currently being tested in clinical trials for its potential to support cellular function in the brain. Developed by Dr. Roberta Diaz-Brenton, Fido-sarm offers promising benefits in improving brain health while addressing menopausal symptoms with reduced risks.
Hormone Replacement Therapy for Menopause Symptoms
There is a discussion about the benefits of hormone replacement therapy (HRT) for women experiencing menopause symptoms. HRT is FDA-approved and known to reduce hot flashes, manage osteoporosis, and address genital urinary symptoms. Professional societies recommend HRT for women who have undergone procedures like hysterectomies or oophorectomies before menopause. Despite past controversies, evidence suggests that hormones may aid in managing depression, sleep issues, brain fog, and memory lapses during perimenopause.
The Role of Sleep in Brain Health
The importance of sleep in maintaining brain health is highlighted. Deep sleep allows the brain to flush out toxins, waste products, and plaques, vital for cognitive function and overall brain health. Disrupted sleep patterns, common in menopausal women, can lead to cognitive decline, inflammation, and a higher risk of various health issues. Strategies to improve sleep hygiene include limiting stimulants like caffeine and alcohol, managing stress levels, and ensuring regular physical activity. Adequate, restful sleep is crucial for overall brain function, particularly during the aging process.
Menopause, often overlooked yet profoundly impactful, marks a critical juncture in a woman’s life, reshaping the brain for half of the global population. This week I am joined by Dr. Lisa Mosconi, a leading neuroscientist in women's health, who challenges outdated perspectives on menopause, emphasizing its neurological significance and advocating for recognition as a neuroendocrine transition. In this episode, we explore diverse menopausal experiences and factors influencing symptoms and shed light on the link between genetics, Alzheimer’s, dementia, lifestyle, neuro-nutrition, and hormone replacement therapy. Dr. Mosconi’s insights provide a crucial antidote to common misconceptions, making this episode essential for women and equally important for everyone, addressing gaps in education about women’s health.
