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The Ultimate Health Podcast

627: Scientist Reveals a Newly Discovered Cause of Insulin Resistance (Not Carb Related) | Dr. Stephanie Venn-Watson

Nov 19, 2024
Dr. Stephanie Venn-Watson, CEO of Seraphina Therapeutics and a leading researcher on pentadecanoic acid (C15:0), discusses its groundbreaking role in health and longevity. She reveals how C15 deficiency can lead to insulin resistance and liver issues. The conversation highlights its importance in dolphin health, suggesting profound implications for human nutrition. Additionally, Venn-Watson emphasizes the need for dietary sources rich in C15, alongside the potential of magnesium and dietary fiber like inulin in promoting overall metabolic wellness.
01:36:14

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Quick takeaways

  • C15, an essential odd-chain saturated fatty acid, plays a crucial role in stabilizing cell membranes and preventing metabolic diseases.
  • Research indicates that C15 deficiency leads to iron overload in the liver, significantly contributing to insulin resistance and cellular fragility.

Deep dives

Role of C15 in Cellular Health

C15, an odd-chain saturated fatty acid, is essential for stabilizing cell membranes, thus preventing cellular breakdown which contributes to aging and diseases. A notable indicator of C15 deficiency is iron overload in the liver, which can lead to insulin resistance, affecting a wide range of bodily functions and overall health. During a clinical trial in Singapore, C15 supplementation was found to assist in cultivating beneficial microorganisms, notably Bifidobacterium adolescentis, which supports metabolic health and longevity. This association highlights the critical role of C15 not only in cellular health but also in maintaining a balance of beneficial gut microbes.

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