627: Scientist Reveals a Newly Discovered Cause of Insulin Resistance (Not Carb Related) | Dr. Stephanie Venn-Watson
Nov 19, 2024
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Dr. Stephanie Venn-Watson, CEO of Seraphina Therapeutics and a leading researcher on pentadecanoic acid (C15:0), discusses its groundbreaking role in health and longevity. She reveals how C15 deficiency can lead to insulin resistance and liver issues. The conversation highlights its importance in dolphin health, suggesting profound implications for human nutrition. Additionally, Venn-Watson emphasizes the need for dietary sources rich in C15, alongside the potential of magnesium and dietary fiber like inulin in promoting overall metabolic wellness.
C15, an essential odd-chain saturated fatty acid, plays a crucial role in stabilizing cell membranes and preventing metabolic diseases.
Research indicates that C15 deficiency leads to iron overload in the liver, significantly contributing to insulin resistance and cellular fragility.
Increasing dietary intake of C15-rich foods and targeted supplementation may enhance metabolic health and longevity, with promising initial study results.
Deep dives
Role of C15 in Cellular Health
C15, an odd-chain saturated fatty acid, is essential for stabilizing cell membranes, thus preventing cellular breakdown which contributes to aging and diseases. A notable indicator of C15 deficiency is iron overload in the liver, which can lead to insulin resistance, affecting a wide range of bodily functions and overall health. During a clinical trial in Singapore, C15 supplementation was found to assist in cultivating beneficial microorganisms, notably Bifidobacterium adolescentis, which supports metabolic health and longevity. This association highlights the critical role of C15 not only in cellular health but also in maintaining a balance of beneficial gut microbes.
Discovery of C15
C15 was discovered serendipitously during research aimed at understanding health and longevity in Navy dolphins, where it emerged as a significant factor correlating with healthier aging. The research revealed that dolphins consuming higher levels of C15-rich fish exhibited fewer signs of metabolic diseases, prompting further examination of this fatty acid's role in human health. This is especially significant as C15 is the first essential fatty acid identified in over ninety years, underscoring the importance of the findings related to nutrition and longevity. The discovery has opened doors to exploring how increasing C15 intake can lead to better health outcomes in humans.
Dietary Sources of C15
Dairy fat, particularly from grass-fed sources, is the primary dietary source of C15 for humans, providing about 100 milligrams per cup of whole milk. Interestingly, specific types of fish, such as certain high-fat fish, also contain C15, although their consumption varies widely among individuals. It's noted that the biodiversity of the diet can influence both the absorption and utilization of this fatty acid, making it essential to choose food wisely. Awareness of dietary patterns and selective choices can significantly impact overall health and C15 levels, creating an opportunity for nutritional correction through food.
Impact of C15 Deficiency
C15 deficiency leads to cellular fragility, which can accelerate aging and trigger conditions such as fatty liver disease and insulin resistance. Iron accumulation as a result of C15 deficiency further exacerbates health problems by fostering a cycle of inflammation and cellular death known as ferroptosis. The emerging evidence highlights that restoring C15 to adequate levels can mitigate these risks and improve metabolic health, particularly concerning liver function and insulin sensitivity. This poses a pressing need to address inadequate C15 intake in modern diets, particularly in populations experiencing a rise in related chronic diseases.
Supplementation and Its Benefits
Supplementation with C15 can aid in rapidly addressing deficiencies and improving health outcomes, especially in populations at risk for chronic diseases linked to such deficiencies. Initial studies suggest that taking C15 can lead to significant improvements in liver enzymes and overall metabolic function within a short time frame. The research indicates that a combination of dietary intake of whole-fat dairy and targeted supplementation can effectively raise C15 levels in the body to optimal ranges. Ongoing research is expanding our understanding of C15's benefits, emphasizing its critical role in health and longevity through both diet and supplementation.
Dr. Stephanie Venn-Watson is the CEO of Seraphina Therapeutics which has been recognized for its extensive research and education on pentadecanoic acid (C15:0).
